Adjuvant Melanoma Therapy — Head-Spinning Progress von Schuchter, Lynn M

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Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade von Benci, Joseph L., Xu, Bihui, Qiu, Yu, Wu, Tony J., Dada, Hannah, Twyman-Saint Victor, Christina, Cucolo, Lisa, Lee, David S.M., Pauken, Kristen E., Huang, Alexander C., Gangadhar, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Feldman, Michael D., Ishwaran, Hemant, Vonderheide, Robert H., Maity, Amit, Wherry, E. John, Minn, Andy J.

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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer von Twyman-Saint Victor, Christina, Rech, Andrew J., Maity, Amit, Rengan, Ramesh, Pauken, Kristen E., Stelekati, Erietta, Benci, Joseph L., Xu, Bihui, Dada, Hannah, Odorizzi, Pamela M., Herati, Ramin S., Mansfield, Kathleen D., Patsch, Dana, Amaravadi, Ravi K., Schuchter, Lynn M., Ishwaran, Hemant, Mick, Rosemarie, Pryma, Daniel A., Xu, Xiaowei, Feldman, Michael D., Gangadhar, Tara C., Hahn, Stephen M., Wherry, E. John, Vonderheide, Robert H., Minn, Andy J.

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Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial von Weber, Jeffrey S, Prof, Gibney, Geoff, MD, Sullivan, Ryan J, MD, Sosman, Jeffrey A, Prof, Slingluff, Craig L, Prof, Lawrence, Donald P, MD, Logan, Theodore F, MD, Schuchter, Lynn M, Prof, Nair, Suresh, MD, Fecher, Leslie, MD, Buchbinder, Elizabeth I, MD, Berghorn, Elmer, BSN, Ruisi, Mary, MD, Kong, George, PhD, Jiang, Joel, PhD, Horak, Christine, PhD, Hodi, F Stephen, Dr

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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response von Chen, Gang, Huang, Alexander C., Zhang, Wei, Zhang, Gao, Wu, Min, Xu, Wei, Yu, Zili, Yang, Jiegang, Wang, Beike, Sun, Honghong, Xia, Houfu, Man, Qiwen, Zhong, Wenqun, Antelo, Leonardo F., Wu, Bin, Xiong, Xuepeng, Liu, Xiaoming, Guan, Lei, Li, Ting, Liu, Shujing, Yang, Ruifeng, Lu, Youtao, Dong, Liyun, McGettigan, Suzanne, Somasundaram, Rajasekharan, Radhakrishnan, Ravi, Mills, Gordon, Lu, Yiling, Kim, Junhyong, Chen, Youhai H., Dong, Haidong, Zhao, Yifang, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Herlyn, Meenhard, Wherry, E. John, Xu, Xiaowei, Guo, Wei

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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion von Khan, Omar, Giles, Josephine R., McDonald, Sierra, Manne, Sasikanth, Ngiow, Shin Foong, Patel, Kunal P., Werner, Michael T., Huang, Alexander C., Alexander, Katherine A., Wu, Jennifer E., Attanasio, John, Yan, Patrick, George, Sangeeth M., Bengsch, Bertram, Staupe, Ryan P., Donahue, Greg, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Kaye, Jonathan, Berger, Shelley L., Wherry, E. John

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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms von Beltra, Jean-Christophe, Manne, Sasikanth, Abdel-Hakeem, Mohamed S., Kurachi, Makoto, Giles, Josephine R., Chen, Zeyu, Casella, Valentina, Ngiow, Shin Foong, Khan, Omar, Huang, Yinghui Jane, Yan, Patrick, Nzingha, Kito, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Wherry, E. John

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Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma von Ma, Xiao-Hong, Piao, Sheng-Fu, Dey, Souvik, McAfee, Quentin, Karakousis, Giorgos, Villanueva, Jessie, Hart, Lori S, Levi, Samuel, Hu, Janice, Zhang, Gao, Lazova, Rossitza, Klump, Vincent, Pawelek, John M, Xu, Xiaowei, Xu, Wei, Schuchter, Lynn M, Davies, Michael A, Herlyn, Meenhard, Winkler, Jeffrey, Koumenis, Constantinos, Amaravadi, Ravi K

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Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy von Zhang, Ying, Kurupati, Raj, Liu, Ling, Zhou, Xiang Yang, Zhang, Gao, Hudaihed, Abeer, Filisio, Flavia, Giles-Davis, Wynetta, Xu, Xiaowei, Karakousis, Giorgos C., Schuchter, Lynn M., Xu, Wei, Amaravadi, Ravi, Xiao, Min, Sadek, Norah, Krepler, Clemens, Herlyn, Meenhard, Freeman, Gordon J., Rabinowitz, Joshua D., Ertl, Hildegund C.J.

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Combined MTOR and autophagy inhibition: Phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma von Rangwala, Reshma, Chang, Yunyoung C, Hu, Janice, Algazy, Kenneth M, Evans, Tracey L, Fecher, Leslie A, Schuchter, Lynn M, Torigian, Drew A, Panosian, Jeffrey T, Troxel, Andrea B, Tan, Kay-See, Heitjan, Daniel F, DeMichele, Angela M, Vaughn, David J, Redlinger, Maryann, Alavi, Abass, Kaiser, Jonathon, Pontiggia, Laura, Davis, Lisa E, O'Dwyer, Peter J, Amaravadi, Ravi K

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Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer von Kwak, Taekyoung, Wang, Fang, Deng, Hui, Condamine, Thomas, Kumar, Vinit, Perego, Michela, Kossenkov, Andrew, Montaner, Luis J., Xu, Xiaowei, Xu, Wei, Zheng, Cathy, Schuchter, Lynn M., Amaravadi, Ravi K., Mitchell, Tara C., Karakousis, Giorgos C., Mulligan, Charles, Nam, Brian, Masters, Gregory, Hockstein, Neil, Bennett, Joseph, Nefedova, Yulia, Gabrilovich, Dmitry I.

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T-cell invigoration to tumour burden ratio associated with anti-PD-1 response von Huang, Alexander C., Postow, Michael A., Orlowski, Robert J., Mick, Rosemarie, Bengsch, Bertram, Manne, Sasikanth, Xu, Wei, Harmon, Shannon, Giles, Josephine R., Wenz, Brandon, Adamow, Matthew, Kuk, Deborah, Panageas, Katherine S., Carrera, Cristina, Wong, Phillip, Quagliarello, Felix, Wubbenhorst, Bradley, D’Andrea, Kurt, Pauken, Kristen E., Herati, Ramin S., Staupe, Ryan P., Schenkel, Jason M., McGettigan, Suzanne, Kothari, Shawn, George, Sangeeth M., Vonderheide, Robert H., Amaravadi, Ravi K., Karakousis, Giorgos C., Schuchter, Lynn M., Xu, Xiaowei, Nathanson, Katherine L., Wolchok, Jedd D., Gangadhar, Tara C., Wherry, E. John

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A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma von Huang, Alexander C., Orlowski, Robert J., Xu, Xiaowei, Mick, Rosemarie, George, Sangeeth M., Yan, Patrick K., Manne, Sasikanth, Kraya, Adam A., Wubbenhorst, Bradley, Dorfman, Liza, D’Andrea, Kurt, Wenz, Brandon M., Liu, Shujing, Chilukuri, Lakshmi, Kozlov, Andrew, Carberry, Mary, Giles, Lydia, Kier, Melanie W., Quagliarello, Felix, McGettigan, Suzanne, Kreider, Kristin, Annamalai, Lakshmanan, Zhao, Qing, Mogg, Robin, Xu, Wei, Blumenschein, Wendy M., Yearley, Jennifer H., Linette, Gerald P., Amaravadi, Ravi K., Schuchter, Lynn M., Herati, Ramin S., Bengsch, Bertram, Nathanson, Katherine L., Farwell, Michael D., Karakousis, Giorgos C., Wherry, E. John, Mitchell, Tara C.

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Phase III Trial of Carboplatin and Paclitaxel With or Without Sorafenib in Metastatic Melanoma von FLAHERTY, Keith T, LEE, Sandra J, FENGMIN ZHAO, SCHUCHTER, Lynn M, FLAHERTY, Lawrence, KEFFORD, Richard, ATKINS, Michael B, LEMING, Philip, KIRKWOOD, John M

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ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression von Zhang, Wei, Zhong, Wenqun, Wang, Beike, Yang, Jiegang, Yang, Jingbo, Yu, Ziyan, Qin, Zhiyuan, Shi, Alex, Xu, Wei, Zheng, Cathy, Schuchter, Lynn M., Karakousis, Giorgos C., Mitchell, Tara C., Amaravadi, Ravi, Herlyn, Meenhard, Dong, Haidong, Gimotty, Phyllis A., Daaboul, George, Xu, Xiaowei, Guo, Wei

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HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors von Guan, Lei, Wu, Bin, Li, Ting, Beer, Lynn A., Sharma, Gaurav, Li, Mingyue, Lee, Chin Nien, Liu, Shujing, Yang, Changsong, Huang, Lili, Frederick, Dennie T., Boland, Genevieve M., Shao, Guangcan, Svitkina, Tatyana M., Cai, Kathy Q., Chen, Fangping, Dong, Meng-Qiu, Mills, Gordon B., Schuchter, Lynn M., Karakousis, Giorgos C., Mitchell, Tara C., Flaherty, Keith T., Speicher, David W., Chen, Youhai H., Herlyn, Meenhard, Amaravadi, Ravi K., Xu, Xiaowei, Guo, Wei

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Oncologist phenotypes and associations with response to a machine learning-based intervention to increase advance care planning: Secondary analysis of a randomized clinical trial von Li, Eric, Manz, Christopher, Liu, Manqing, Chen, Jinbo, Chivers, Corey, Braun, Jennifer, Schuchter, Lynn Mara, Kumar, Pallavi, Patel, Mitesh S, Shulman, Lawrence N, Parikh, Ravi B

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Association of Antibiotic Exposure With Survival and Toxicity in Patients With Melanoma Receiving Immunotherapy von Mohiuddin, Jahan J, Chu, Brian, Facciabene, Andrea, Poirier, Kendra, Wang, Xingmei, Doucette, Abigail, Zheng, Cathy, Xu, Wei, Anstadt, Emily J, Amaravadi, Ravi K, Karakousis, Giorgos C, Mitchell, Tara C, Huang, Alexander C, Shabason, Jacob E, Lin, Alexander, Swisher-McClure, Samuel, Maity, Amit, Schuchter, Lynn M, Lukens, John N

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BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma von Mehnert, Janice M, Mitchell, Tara C, Huang, Alexander C, Aleman, Tomas S, Kim, Benjamin J, Schuchter, Lynn M, Linette, Gerald P, Karakousis, Giorgos C, Mitnick, Sheryl, Giles, Lydia, Carberry, Mary, Frey, Noelle, Kossenkov, Andrew, Groisberg, Roman, Hernandez-Aya, Leonel F, Ansstas, George, Silk, Ann W, Chandra, Sunandana, Sosman, Jeffrey A, Gimotty, Phyllis A, Mick, Rosemarie, Amaravadi, Ravi K

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Sentinel Lymph Node Biopsy for Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Joint Clinical Practice Guideline von WONG, Sandra L, BALCH, Charles M, DIRK NOYES, R, SCHUCHTER, Lynn M, VALSECCHI, Matias E, WEAVER, Donald L, LYMAN, Gary H, HURLEY, Patricia, AGARWALA, Sanjiv S, AKHURST, Timothy J, COCHRAN, Alistair, CORMIER, Janice N, GORMAN, Mark, KIM, Theodore Y, MCMASTERS, Kelly M

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