Global mRNA selection mechanisms for translation initiation von Costello, Joseph, Castelli, Lydia M, Rowe, William, Kershaw, Christopher J, Talavera, David, Mohammad-Qureshi, Sarah S, Sims, Paul F G, Grant, Christopher M, Pavitt, Graham D, Hubbard, Simon J, Ashe, Mark P

Volltext

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS von Varcianna, André, Myszczynska, Monika A., Castelli, Lydia M., O'Neill, Brendan, Kim, Yeseul, Talbot, Jordan, Nyberg, Sophie, Nyamali, Immanuelle, Heath, Paul R., Stopford, Matthew J., Hautbergue, Guillaume M., Ferraiuolo, Laura

Volltext

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function von Mihaylov, Simeon R., Castelli, Lydia M., Lin, Ya-Hui, Gül, Aytac, Soni, Nikita, Hastings, Christopher, Flynn, Helen R., Păun, Oana, Dickman, Mark J., Snijders, Ambrosius P., Goldstone, Robert, Bandmann, Oliver, Shelkovnikova, Tatyana A., Mortiboys, Heather, Ultanir, Sila K., Hautbergue, Guillaume M.

Volltext

Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses von Costello, Joseph L, Kershaw, Christopher J, Castelli, Lydia M, Talavera, David, Rowe, William, Sims, Paul F G, Ashe, Mark P, Grant, Christopher M, Hubbard, Simon J, Pavitt, Graham D

Volltext

Granules Harboring Translationally Active mRNAs Provide a Platform for P-Body Formation following Stress von Lui, Jennifer, Castelli, Lydia M., Pizzinga, Mariavittoria, Simpson, Clare E., Hoyle, Nathaniel P., Bailey, Kathryn L., Campbell, Susan G., Ashe, Mark P.

Volltext

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features von Shaw, Matthew P, Higginbottom, Adrian, McGown, Alexander, Castelli, Lydia M, James, Evlyn, Hautbergue, Guillaume M, Shaw, Pamela J, Ramesh, Tennore M

Volltext

Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes von Nwokoye, Ebelechukwu C., AlNaseem, Eiman, Crawford, Robert A., Castelli, Lydia M., Jennings, Martin D., Kershaw, Christopher J., Pavitt, Graham D.

Volltext

A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations von Allen, Scott P, Al Sultan, Afnan, Kabucho Kibirige, Elaine, Tonkiss, Erin, Hamer, Keaton J, Castelli, Lydia M, Lin, Ya-Hui, Roscoe, Sarah, Stefanidis, Nikolaos, Mead, Richard J, Highley, J Robin, Cooper-Knock, Johnathan, Hautbergue, Guillaume M, Heath, Paul R, Kirby, Janine, Shaw, Pamela J

Volltext

RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration von Castelli, Lydia M, Benson, Bridget C, Huang, Wan-Ping, Lin, Ya-Hui, Hautbergue, Guillaume M

Volltext

The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response von Kershaw, Christopher J, Costello, Joseph L, Castelli, Lydia M, Talavera, David, Rowe, William, Sims, Paul F G, Ashe, Mark P, Hubbard, Simon J, Pavitt, Graham D, Grant, Chris M

Volltext

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis von Castelli, Lydia M, Cutillo, Luisa, Souza, Cleide Dos Santos, Sanchez-Martinez, Alvaro, Granata, Ilaria, Lin, Ya-Hui, Myszczynska, Monika A, Heath, Paul R, Livesey, Matthew R, Ning, Ke, Azzouz, Mimoun, Shaw, Pamela J, Guarracino, Mario R, Whitworth, Alexander J, Ferraiuolo, Laura, Milo, Marta, Hautbergue, Guillaume M

Volltext

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation von Castelli, Lydia M, Talavera, David, Kershaw, Christopher J, Mohammad-Qureshi, Sarah S, Costello, Joseph L, Rowe, William, Sims, Paul F G, Grant, Christopher M, Hubbard, Simon J, Ashe, Mark P, Pavitt, Graham D

Volltext

Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regul... von Castelli, Lydia M, Lui, Jennifer, Campbell, Susan G, Rowe, William, Zeef, Leo A H, Holmes, Leah E A, Hoyle, Nathaniel P, Bone, Jonathon, Selley, Julian N, Sims, Paul F G, Ashe, Mark P

Volltext

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation von Bauer, Claudia S, Webster, Christopher P, Shaw, Allan C, Kok, Jannigje R, Castelli, Lydia M, Lin, Ya-Hui, Smith, Emma F, Illanes-Álvarez, Francisco, Higginbottom, Adrian, Shaw, Pamela J, Azzouz, Mimoun, Ferraiuolo, Laura, Hautbergue, Guillaume M, Grierson, Andrew J, De Vos, Kurt J

Volltext

Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins von Cridge, Andrew G, Castelli, Lydia M, Smirnova, Julia B, Selley, Julian N, Rowe, William, Hubbard, Simon J, McCarthy, John E G, Ashe, Mark P, Grant, Christopher M, Pavitt, Graham D

Volltext

Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae von Egbe, Nkechi E, Dornelles, Tawni O, Paget, Caroline M, Castelli, Lydia M, Ashe, Mark P

Volltext

RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strat... von Burrows, David J, McGown, Alexander, Abduljabbar, Olfat, Castelli, Lydia M, Shaw, Pamela J, Hautbergue, Guillaume M, Ramesh, Tennore M

Volltext

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis von Allen, Scott P, Hall, Benjamin, Castelli, Lydia M, Francis, Laura, Woof, Ryan, Siskos, Alexandros P, Kouloura, Eirini, Gray, Elizabeth, Thompson, Alexander G, Talbot, Kevin, Higginbottom, Adrian, Myszczynska, Monika, Allen, Chloe F, Stopford, Matthew J, Hemingway, Jordan, Bauer, Claudia S, Webster, Christopher P, De Vos, Kurt J, Turner, Martin R, Keun, Hector C, Hautbergue, Guillaume M, Ferraiuolo, Laura, Shaw, Pamela J

Volltext

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease von Gatto, Noemi, Dos Santos Souza, Cleide, Shaw, Allan C., Bell, Simon M., Myszczynska, Monika A., Powers, Samantha, Meyer, Kathrin, Castelli, Lydia M., Karyka, Evangelia, Mortiboys, Heather, Azzouz, Mimoun, Hautbergue, Guillaume M., Márkus, Nóra M., Shaw, Pamela J., Ferraiuolo, Laura

Volltext

Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders von Castelli, Lydia M, Huang, Wan-Ping, Lin, Ya-Hui, Chang, Kung-Yao, Hautbergue, Guillaume M

Volltext