A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors von Becher, Oren J, Millard, Nathan E, Modak, Shakeel, Kushner, Brian H, Haque, Sofia, Spasojevic, Ivan, Trippett, Tanya M, Gilheeney, Stephen W, Khakoo, Yasmin, Lyden, David C, De Braganca, Kevin C, Kolesar, Jill M, Huse, Jason T, Kramer, Kim, Cheung, Nai-Kong V, Dunkel, Ira J

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Oligodendrocyte Progenitor Cells Promote Neovascularization in Glioma by Disrupting the Blood-Brain Barrier von YUJIE HUANG, HOFFMAN, Caitlin, LYDEN, David C, GREENFIELD, Jeffrey P, RAJAPPA, Prajwal, KIM, Joon-Hyung, WENHUO HU, HUSE, Jason, ZHONGSHU TANG, XURI LI, WEKSLER, Babette, BROMBERG, Jacqueline

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Genomic mapping of metastatic organotropism in lung adenocarcinoma von Lengel, Harry B., Mastrogiacomo, Brooke, Connolly, James G., Tan, Kay See, Liu, Yuan, Fick, Cameron N., Dunne, Elizabeth G., He, Di, Lankadasari, Manendra B., Satravada, Baby Anusha, Sun, Yichao, Kundra, Ritika, Fong, Chris, Smith, Shaleigh, Riely, Gregory J., Rudin, Charles M., Gomez, Daniel R., Solit, David B., Berger, Michael F., Li, Bob T., Mayo, Marty W., Matei, Irina, Lyden, David C., Adusumilli, Prasad S., Schultz, Nikolaus, Sanchez-Vega, Francisco, Jones, David R.

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Disease Control and Ototoxicity Using Intensity-Modulated Radiation Therapy Tumor-Bed Boost for Medulloblastoma von Polkinghorn, William R., M.D, Dunkel, Ira J., M.D, Souweidane, Mark M., M.D, Khakoo, Yasmin, M.D, Lyden, David C., M.D., Ph.D, Gilheeney, Stephen W., M.D, Becher, Oren J., M.D, Budnick, Amy S., M.Ed., M.P.H, Wolden, Suzanne L., M.D

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Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas von Kerbel, Robert S, Benezra, Robert, Lyden, David C, Hattori, Koichi, Heissig, Beate, Nolan, Daniel J, Mittal, Vivek, Shaked, Yuval, Dias, Sergio, Bertolini, Francesco, Rafii, Shahin

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Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems von Khan, Imran, Gril, Brunilde, Hoshino, Ayuko, Yang, Howard H., Lee, Maxwell P., Difilippantonio, Simone, Lyden, David C., Steeg, Patricia S.

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A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors von Becher, Oren J., Gilheeney, Stephen W., Khakoo, Yasmin, Lyden, David C., Haque, Sofia, Braganca, Kevin C., Kolesar, Jill M., Huse, Jason T., Modak, Shakeel, Wexler, Leonard H., Kramer, Kim, Spasojevic, Ivan, Dunkel, Ira J.

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Breast adipose tissue‐derived extracellular vesicles from obese women alter tumor cell metabolism von Liu, Shuchen, Benito‐Martin, Alberto, Pelissier Vatter, Fanny A, Hanif, Sarah Z, Liu, Catherine, Bhardwaj, Priya, Sethupathy, Praveen, Farghli, Alaa R, Piloco, Phoebe, Paik, Paul, Mushannen, Malik, Dong, Xue, Otterburn, David M, Cohen, Leslie, Bareja, Rohan, Krumsiek, Jan, Cohen‐Gould, Leona, Calto, Samuel, Spector, Jason A, Elemento, Olivier, Lyden, David C, Brown, Kristy A

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Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells von Rajappa, Prajwal, Cobb, William S, Vartanian, Emma, Huang, Yujie, Daly, Laura, Hoffman, Caitlin, Zhang, Jane, Shen, Beiyi, Yanowitch, Rachel, Garg, Kunal, Cisse, Babacar, Haddock, Sara, Huse, Jason, Pisapia, David J, Chan, Timothy A, Lyden, David C, Bromberg, Jacqueline F, Greenfield, Jeffrey P

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KRAS G12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma von Jones, Gregory D, Caso, Raul, Tan, Kay See, Mastrogiacomo, Brooke, Sanchez-Vega, Francisco, Liu, Yuan, Connolly, James G, Murciano-Goroff, Yonina R, Bott, Matthew J, Adusumilli, Prasad S, Molena, Daniela, Rocco, Gaetano, Rusch, Valerie W, Sihag, Smita, Misale, Sandra, Yaeger, Rona, Drilon, Alexander, Arbour, Kathryn C, Riely, Gregory J, Rosen, Neal, Lito, Piro, Zhang, Haiying, Lyden, David C, Rudin, Charles M, Jones, David R, Li, Bob T, Isbell, James M

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Novel activating BRAF fusion identifies a recurrent alternative mechanism for ERK activation in pediatric Langerhans cell histiocytosis von Zarnegar, Sara, Durham, Benjamin H., Khattar, Pallavi, Shukla, Neerav N., Benayed, Ryma, Lacouture, Mario E., Lavi, Ehud, Lyden, David C., Diamond, Eli L., Dunkel, Ira J., Abdel‐Wahab, Omar

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Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers von Bezdan, Daniela, Grigorev, Kirill, Meydan, Cem, Pelissier Vatter, Fanny A., Cioffi, Michele, Rao, Varsha, MacKay, Matthew, Nakahira, Kiichi, Burnham, Philip, Afshinnekoo, Ebrahim, Westover, Craig, Butler, Daniel, Mozsary, Chris, Donahoe, Timothy, Foox, Jonathan, Mishra, Tejaswini, Lucotti, Serena, Rana, Brinda K., Melnick, Ari M., Zhang, Haiying, Matei, Irina, Kelsen, David, Yu, Kenneth, Lyden, David C., Taylor, Lynn, Bailey, Susan M., Snyder, Michael P., Garrett-Bakelman, Francine E., Ossowski, Stephan, De Vlaminck, Iwijn, Mason, Christopher E.

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Intensive multimodality therapy for patients with stage 4a metastatic retinoblastoma von Dunkel, Ira J., Khakoo, Yasmin, Kernan, Nancy A., Gershon, Timothy, Gilheeney, Stephen, Lyden, David C., Wolden, Suzanne L., Orjuela, Manuela, Gardner, Sharon L., Abramson, David H.

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Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver von Costa-Silva, Bruno, Aiello, Nicole M., Ocean, Allyson J., Singh, Swarnima, Zhang, Haiying, Thakur, Basant Kumar, Becker, Annette, Hoshino, Ayuko, Mark, Milica Tešić, Molina, Henrik, Xiang, Jenny, Zhang, Tuo, Theilen, Till-Martin, García-Santos, Guillermo, Williams, Caitlin, Ararso, Yonathan, Huang, Yujie, Rodrigues, Gonçalo, Shen, Tang-Long, Labori, Knut Jørgen, Lothe, Inger Marie Bowitz, Kure, Elin H., Hernandez, Jonathan, Doussot, Alexandre, Ebbesen, Saya H., Grandgenett, Paul M., Hollingsworth, Michael A., Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Schwartz, Robert E., Matei, Irina, Peinado, Héctor, Stanger, Ben Z., Bromberg, Jacqueline, Lyden, David

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Webinar | Deciphering cancer: Understanding tumor invasion and the metastatic microenvironment von Lyden, David C., Rafii, Shahin

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362 ARREST OF EXOCYTOSIS/ENDOCYTOSIS COUPLING INHIBITS THE PROGRESSION OF PANCREATIC DUCTAL ADENOCARCINOMA IN MICE von Zhao, Chun-Mei, Rabben, Hanne-Line, Resell, Mathilde, Olsen, Magnus K., Zhang, Haiying, Batra, Surinder K., Lyden, David C., Wang, Timothy C., Chen, Duan

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A Novel Method for Targeted Gene Therapy in Ischemic Tissues through Viral Transfection of an Expression Cassette Containing Multiple Repetitions of Hypoxia Response Element von Cross, Kevin J., Bomsztyk, Elan D., Weinstein, Andrew L., Teo, Esther H., Spector, Jason A., Lyden, David C.

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The Space Omics and Medical Atlas (SOMA) and international astronaut biobank von Overbey, Eliah G., Kim, JangKeun, Tierney, Braden T., Park, Jiwoon, Houerbi, Nadia, Lucaci, Alexander G., Garcia Medina, Sebastian, Damle, Namita, Najjar, Deena, Grigorev, Kirill, Afshin, Evan E., Ryon, Krista A., Sienkiewicz, Karolina, Klotz, Remi, Ortiz, Veronica, MacKay, Matthew, Schweickart, Annalise, Sierra, Maria A., Valenzuela, Matias F., Dantas, Ezequiel, Nelson, Theodore M., Foox, Jonathan, Narayanan, S. Anand, Schmidt, Caleb M., Schmidt, Michael A., Schmidt, Julian C., Mullane, Sean, Tigchelaar, Seth Stravers, Levitte, Steven, Westover, Craig, Bhattacharya, Chandrima, Lucotti, Serena, Wain Hirschberg, Jeremy, Proszynski, Jacqueline, Burke, Marissa, Kleinman, Ashley S., Loy, Conor, Mzava, Omary, Lenz, Joan, Paul, Doru, Mozsary, Christopher, Sanders, Lauren M., Taylor, Lynn E., Khan, Sharib A., Suhail Mohamad, Mir, Byhaqui, Syed Gufran Ahmad, Gajadhar, Aaron S., Tandel, Purvi, Yang, Qiu, Chu, Jessica, Benz, Ryan W., Siddiqui, Asim, Hornburg, Daniel, Blease, Kelly, Moreno, Juan, Boddicker, Andrew, Zhao, Junhua, Lajoie, Bryan, Scott, Ryan T., Gilbert, Rachel R., Lai Polo, San-huei, Altomare, Andrew, Kruglyak, Semyon, Levy, Shawn, Ariyapala, Ishara, Beer, Joanne, Zhang, Bingqing, Hudson, Briana M., Rininger, Aric, Church, Sarah E., Beheshti, Afshin, Church, George M., Smith, Scott M., Crucian, Brian E., Zwart, Sara R., Matei, Irina, Lyden, David C., Garrett-Bakelman, Francine, Krumsiek, Jan, Chen, Qiuying, Miller, Dawson, Shuga, Joe, Williams, Stephen, Nemec, Corey, Trudel, Guy, Pelchat, Martin, Laneuville, Odette, De Vlaminck, Iwijn, Gross, Steven, Bolton, Kelly L., Bailey, Susan M., Furman, David, Melnick, Ari M., Costes, Sylvain V., Shirah, Bader, Yu, Min, Menon, Anil S., Mateus, Jaime, Meydan, Cem, Mason, Christopher E.

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Exosomal MEK1 delays tumor growth by promoting anti-tumor immunity von Searles, Stephen, Lyden, David C, Bui, Jack D

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KRASG12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma von Jones, Gregory D., Caso, Raul, Tan, Kay See, Mastrogiacomo, Brooke, Sanchez-Vega, Francisco, Liu, Yuan, Connolly, James G., Murciano-Goroff, Yonina R., Bott, Matthew J., Adusumilli, Prasad S., Molena, Daniela, Rocco, Gaetano, Rusch, Valerie W., Sihag, Smita, Misale, Sandra, Yaeger, Rona, Drilon, Alexander, Arbour, Kathryn C., Riely, Gregory J., Rosen, Neal, Lito, Piro, Zhang, Haiying, Lyden, David C., Rudin, Charles M., Jones, David R., Li, Bob T., Isbell, James M.

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