SAR3419: an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies von Blanc, Veronique, Bousseau, Anne, Caron, Anne, Carrez, Chantal, Lutz, Robert J, Lambert, John M

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Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing von ERICKSON, Hans K, PARK, Peter U, WIDDISON, Wayne C, KOVTUN, Yelena V, GARRETT, Lisa M, HOFFMAN, Karen, LUTZ, Robert J, GOLDMACHER, Victor S, BLÄTTLER, Walter A

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Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage von Kellogg, Brenda A, Garrett, Lisa, Kovtun, Yelena, Lai, Katharine C, Leece, Barbara, Miller, Michael, Payne, Gillian, Steeves, Rita, Whiteman, Kathleen R, Widdison, Wayne, Xie, Hongsheng, Singh, Rajeeva, Chari, Ravi V. J, Lambert, John M, Lutz, Robert J

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Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance von KOVTUN, Yelena V, AUDETTE, Charlene A, LAI, Katharine C, WIDDISON, Wayne C, KELLOGG, Brenda, JOHNSON, Holly, PINKAS, Jan, LUTZ, Robert J, SINGH, Rajeeva, GOLDMACHER, Victor S, CHARI, Ravi V. J, MAYO, Michele F, JONES, Gregory E, DOHERTY, Heather, MALONEY, Erin K, ERICKSON, Hans K, XIUXIA SUN, WILHELM, Sharon, AB, Olga

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The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo von Ikeda, Hiroshi, Hideshima, Teru, Fulciniti, Mariateresa, Lutz, Robert J, Yasui, Hiroshi, Okawa, Yutaka, Kiziltepe, Tanyel, Vallet, Sonia, Pozzi, Samantha, Santo, Loredana, Perrone, Giulia, Tai, Yu-Tzu, Cirstea, Diana, Raje, Noopur S, Uherek, Christoph, Dälken, Benjamin, Aigner, Silke, Osterroth, Frank, Munshi, Nikhil, Richardson, Paul, Anderson, Kenneth C

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Antibody-maytansinoid conjugates for the treatment of myeloma von Lutz, Robert J., Whiteman, Kathleen R.

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Drug Elimination Kinetics Following Subconjunctival Injection Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging von Kim, Stephanie H., Csaky, Karl G., Wang, Nam Sun, Lutz, Robert J.

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Transport Barriers in Transscleral Drug Delivery for Retinal Diseases von Kim, Stephanie H., Lutz, Robert J., Wang, Nam Sun, Robinson, Michael R.

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A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide von Robinson, Michael R., Lee, Susan S., Kim, Hyuncheol, Kim, Stephanie, Lutz, Robert J., Galban, Craig, Bungay, Peter M., Yuan, Peng, Wang, Nam Sun, Kim, Jonghyeon, Csaky, Karl G.

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IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors von Ab, Olga, Whiteman, Kathleen R, Bartle, Laura M, Sun, Xiuxia, Singh, Rajeeva, Tavares, Daniel, LaBelle, Alyssa, Payne, Gillian, Lutz, Robert J, Pinkas, Jan, Goldmacher, Victor S, Chittenden, Thomas, Lambert, John M

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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate von Lewis Phillips, Gail D, Li, Guangmin, Dugger, Debra L, Crocker, Lisa M, Parsons, Kathryn L, Mai, Elaine, Blättler, Walter A, Lambert, John M, Chari, Ravi V J, Lutz, Robert J, Wong, Wai Lee T, Jacobson, Frederic S, Koeppen, Hartmut, Schwall, Ralph H, Kenkare-Mitra, Sara R, Spencer, Susan D, Sliwkowski, Mark X

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The pharmacokinetics of rituximab following an intravitreal injection von Kim, Hyuncheol, Csaky, Karl G., Chan, Chi-Chao, Bungay, Peter M., Lutz, Robert J., Dedrick, Robert L., Yuan, Peng, Rosenberg, Jay, Grillo-Lopez, Antonio J., Wilson, Wyndham H., Robinson, Michael R.

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A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies von Deckert, Jutta, Park, Peter U., Chicklas, Sharon, Yi, Yong, Li, Min, Lai, Katharine C., Mayo, Michele F., Carrigan, Christina N., Erickson, Hans K., Pinkas, Jan, Lutz, Robert J., Chittenden, Thomas, Lambert, John M.

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αv Integrin-Targeted Immunoconjugates Regress Established Human Tumors in Xenograft Models von QIMING CHEN, MILLAR, Hillary J, ANDERSON, G. Mark, MCCABE, Francis L, MANNING, Carol D, STEEVES, Rita, LAI, Kate, KELLOGG, Brenda, LUTZ, Robert J, TRIKHA, Mohit, NAKADA, Marian T

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Design of Coltuximab Ravtansine, a CD19-Targeting Antibody–Drug Conjugate (ADC) for the Treatment of B‑Cell Malignancies: Structure–Activity Relationships and Preclinical Evaluatio... von Hong, E. Erica, Erickson, Hans, Lutz, Robert J, Whiteman, Kathleen R, Jones, Gregory, Kovtun, Yelena, Blanc, Veronique, Lambert, John M

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Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer von Widdison, Wayne C, Wilhelm, Sharon D, Cavanagh, Emily E, Whiteman, Kathleen R, Leece, Barbara A, Kovtun, Yelena, Goldmacher, Victor S, Xie, Hongsheng, Steeves, Rita M, Lutz, Robert J, Zhao, Robert, Wang, Lintao, Blättler, Walter A, Chari, Ravi V. J

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Bax Interacts with the Permeability Transition Pore to Induce Permeability Transition and Cytochrome c Release in Isolated Mitochondria von Narita, Masashi, Shimizu, Shigeomi, Ito, Toshinori, Chittenden, Thomas, Lutz, Robert J., Matsuda, Hikaru, Tsujimoto, Yoshihide

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Estimation of the differential pressure at renal artery stenoses von Yim, Peter J., Cebral, Juan R., Weaver, Ashley, Lutz, Robert J., Soto, Orlando, Vasbinder, G. Boudewijn C., Ho, Vincent B., Choyke, Peter L.

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Expression of bbc3, A Pro-Apoptotic BH3-Only Gene, is Regulated by Diverse Cell Death and Survival Signals von Han, Jia-wen, Flemington, Cathy, Houghton, Anne B., Gu, Zhengming, Zambetti, Gerard P., Lutz, Robert J., Zhu, Li, Chittenden, Thomas

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Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models von Whiteman, Kathleen R, Johnson, Holly A, Mayo, Michele F, Audette, Charlene A, Carrigan, Christina N, LaBelle, Alyssa, Zukerberg, Lawrence, Lambert, John M, Lutz, Robert J

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