Biased agonists of GPR84 and insights into biological control von Luscombe, Vincent B., Wang, Pinqi, Russell, Angela J., Greaves, David R.

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20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor? von Luscombe, Vincent B, Lucy, Daniel, Bataille, Carole J R, Russell, Angela J, Greaves, David R

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Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84 von Luscombe, Vincent B., Baena-López, Luis Alberto, Bataille, Carole J.R., Russell, Angela J., Greaves, David R.

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Development of Highly Potent, G‑Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists von Wang, Pinqi, Raja, Arun, Luscombe, Vincent B., Bataille, Carole J. R., Lucy, Daniel, Rogga, Vanessa V., Greaves, David R., Russell, Angela J.

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Challenges in the development of an M 4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs von Wood, Michael R, Noetzel, Meredith J, Poslusney, Michael S, Melancon, Bruce J, Tarr, James C, Lamsal, Atin, Chang, Sichen, Luscombe, Vincent B, Weiner, Rebecca L, Cho, Hyekyung P, Bubser, Michael, Jones, Carrie K, Niswender, Colleen M, Wood, Michael W, Engers, Darren W, Brandon, Nicholas J, Duggan, Mark E, Conn, P Jeffrey, Bridges, Thomas M, Lindsley, Craig W

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Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu 7 Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1 H-1,2,4-triazol-1-yl)-5-(tr... von Reed, Carson W, Yohn, Samantha E, Washecheck, Jordan P, Roenfanz, Hanna F, Quitalig, Marc C, Luscombe, Vincent B, Jenkins, Matthew T, Rodriguez, Alice L, Engers, Darren W, Blobaum, Anna L, Conn, P Jeffrey, Niswender, Colleen M, Lindsley, Craig W

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Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5‑a]p... von Childress, Elizabeth S, Wieting, Joshua M, Felts, Andrew S, Breiner, Megan M, Long, Madeline F, Luscombe, Vincent B, Rodriguez, Alice L, Cho, Hyekyung P, Blobaum, Anna L, Niswender, Colleen M, Emmitte, Kyle A, Conn, P. Jeffrey, Lindsley, Craig W

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Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1 von Spearing, Paul K., Cho, Hyekyung P., Luscombe, Vincent B., Blobaum, Anna L., Boutaud, Olivier, Engers, Darren W., Rodriguez, Alice L., Niswender, Colleen M., Jeffrey Conn, P., Lindsley, Craig W., Bender, Aaron M.

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Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 von Spearing, Paul K, Cho, Hyekyung P, Luscombe, Vincent B, Blobaum, Anna L, Boutaud, Olivier, Engers, Darren W, Rodriguez, Alice L, Niswender, Colleen M, Jeffrey Conn, P, Lindsley, Craig W, Bender, Aaron M

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Discovery of VU6008677: A Structurally Distinct Tricyclic M4 Positive Allosteric Modulator with Improved CYP450 Profile von Capstick, Rory A., Bollinger, Sean R., Engers, Julie L., Long, Madeline F., Chang, Sichen, Luscombe, Vincent B., Rodriguez, Alice L., Niswender, Colleen M., Bridges, Thomas M., Boutaud, Olivier, Conn, P. Jeffrey, Engers, Darren W., Lindsley, Craig W., Temple, Kayla J.

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Discovery of VU6008677: A Structurally Distinct Tricyclic M 4 Positive Allosteric Modulator with Improved CYP450 Profile von Capstick, Rory A, Bollinger, Sean R, Engers, Julie L, Long, Madeline F, Chang, Sichen, Luscombe, Vincent B, Rodriguez, Alice L, Niswender, Colleen M, Bridges, Thomas M, Boutaud, Olivier, Conn, P Jeffrey, Engers, Darren W, Lindsley, Craig W, Temple, Kayla J

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Discovery of structurally distinct tricyclic M 4 positive allosteric modulator (PAM) chemotypes - Part 2 von Long, Madeline F, Capstick, Rory A, Spearing, Paul K, Engers, Julie L, Gregro, Alison R, Bollinger, Sean R, Chang, Sichen, Luscombe, Vincent B, Rodriguez, Alice L, Cho, Hyekyung P, Niswender, Colleen M, Bridges, Thomas M, Conn, P Jeffrey, Lindsley, Craig W, Engers, Darren W, Temple, Kayla J

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Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) von Engers, Julie L., Baker, Logan A., Chang, Sichen, Luscombe, Vincent B., Rodriguez, Alice L., Niswender, Colleen M., Cho, Hyekyung P., Bubser, Michael, Gray, Analisa Thompson, Jones, Carrie K., Peng, Weimin, Rook, Jerri M., Bridges, Thomas M., Boutaud, Olivier, Conn, P. Jeffrey, Engers, Darren W., Lindsley, Craig W., Temple, Kayla J.

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Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M 4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) von Engers, Julie L, Baker, Logan A, Chang, Sichen, Luscombe, Vincent B, Rodriguez, Alice L, Niswender, Colleen M, Cho, Hyekyung P, Bubser, Michael, Gray, Analisa Thompson, Jones, Carrie K, Peng, Weimin, Rook, Jerri M, Bridges, Thomas M, Boutaud, Olivier, Conn, P Jeffrey, Engers, Darren W, Lindsley, Craig W, Temple, Kayla J

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Discovery of structurally distinct tricyclic M 4 positive allosteric modulator (PAM) chemotypes von Temple, Kayla J, Long, Madeline F, Engers, Julie L, Watson, Katherine J, Chang, Sichen, Luscombe, Vincent B, Rodriguez, Alice L, Niswender, Colleen M, Bridges, Thomas M, Conn, P Jeffrey, Engers, Darren W, Lindsley, Craig W

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Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2 von Long, Madeline F., Capstick, Rory A., Spearing, Paul K., Engers, Julie L., Gregro, Alison R., Bollinger, Sean R., Chang, Sichen, Luscombe, Vincent B., Rodriguez, Alice L., Cho, Hyekyung P., Niswender, Colleen M., Bridges, Thomas M., Conn, P. Jeffrey, Lindsley, Craig W., Engers, Darren W., Temple, Kayla J.

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Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping von Temple, Kayla J., Engers, Julie L., Long, Madeline F., Gregro, Alison R., Watson, Katherine J., Chang, Sichen, Jenkins, Matthew T., Luscombe, Vincent B., Rodriguez, Alice L., Niswender, Colleen M., Bridges, Thomas M., Conn, P. Jeffrey, Engers, Darren W., Lindsley, Craig W.

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Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M 4 positive allosteric modulator (PAM) chemotype von Temple, Kayla J, Engers, Julie L, Long, Madeline F, Watson, Katherine J, Chang, Sichen, Luscombe, Vincent B, Jenkins, Matthew T, Rodriguez, Alice L, Niswender, Colleen M, Bridges, Thomas M, Conn, P Jeffrey, Engers, Darren W, Lindsley, Craig W

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Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia von Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Poslusney, Michael S., Nance, Kellie D., Hurtado, Miguel A., Luscombe, Vincent B., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Chang, Sichen, Bubser, Michael, Blobaum, Anna L., Engers, Darren W., Niswender, Colleen M., Jones, Carrie K., Brandon, Nicholas J., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.

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Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes von Temple, Kayla J., Long, Madeline F., Engers, Julie L., Watson, Katherine J., Chang, Sichen, Luscombe, Vincent B., Rodriguez, Alice L., Niswender, Colleen M., Bridges, Thomas M., Conn, P. Jeffrey, Engers, Darren W., Lindsley, Craig W.

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