Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression von Fairfax, Benjamin P., Humburg, Peter, Makino, Seiko, Naranbhai, Vivek, Wong, Daniel, Lau, Evelyn, Jostins, Luke, Plant, Katharine, Andrews, Robert, McGee, Chris, Knight, Julian C.

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Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease von Lee, James C, Biasci, Daniele, Roberts, Rebecca, Gearry, Richard B, Mansfield, John C, Ahmad, Tariq, Prescott, Natalie J, Satsangi, Jack, Wilson, David C, Jostins, Luke, Anderson, Carl A, Traherne, James A, Lyons, Paul A, Parkes, Miles, Smith, Kenneth G C

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Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation von Ryzhakov, Grigory, Almuttaqi, Hannah, Corbin, Alastair L., Berthold, Dorothée L., Khoyratty, Tariq, Eames, Hayley L., Bullers, Samuel, Pearson, Claire, Ai, Zhichao, Zec, Kristina, Bonham, Sarah, Fischer, Roman, Jostins-Dean, Luke, Travis, Simon P. L., Kessler, Benedikt M., Udalova, Irina A.

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Environmental variables and genome-environment interactions predicting IBD diagnosis in large UK cohort von Yang, Alan Z., Jostins-Dean, Luke

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Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation von Glinos, Dafni A., Soskic, Blagoje, Williams, Cayman, Kennedy, Alan, Jostins, Luke, Sansom, David M., Trynka, Gosia

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Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation von Zhou, Dingxi, Borsa, Mariana, Puleston, Daniel J., Zellner, Susanne, Capera, Jesusa, Sanderson, Sharon, Schifferer, Martina, Hester, Svenja S., Ge, Xin, Fischer, Roman, Jostins, Luke, Behrends, Christian, Alsaleh, Ghada, Simon, Anna Katharina

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Microindel detection in short-read sequence data von Krawitz, Peter, Rödelsperger, Christian, Jäger, Marten, Jostins, Luke, Bauer, Sebastian, Robinson, Peter N.

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Using genetic prediction from known complex disease Loci to guide the design of next-generation sequencing experiments von Jostins, Luke, Levine, Adam P, Barrett, Jeffrey C

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Trinculo: Bayesian and frequentist multinomial logistic regression for genome-wide association studies of multi-category phenotypes von Jostins, Luke, McVean, Gilean

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GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome von Bonfiglio, Ferdinando, Liu, Xingrong, Smillie, Christopher, Pandit, Anita, Kurilshikov, Alexander, Bacigalupe, Rodrigo, Zheng, Tenghao, Nim, Hieu, Garcia-Etxebarria, Koldo, Bujanda, Luis, Andreasson, Anna, Agreus, Lars, Walter, Susanna, Abecasis, Gonçalo, Eijsbouts, Chris, Jostins, Luke, Parkes, Miles, Hughes, David A., Timpson, Nicholas, Raes, Jeroen, Franke, Andre, Kennedy, Nicholas A., Regev, Aviv, Zhernakova, Alexandra, Simren, Magnus, Camilleri, Michael, D’Amato, Mauro

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Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium von Deng, Yun, Perry, Thomas A, Hulley, Philippa, Maciewicz, Rose A, Mitchelmore, Joanna, Perry, Darryl, Larsson, Staffan, Brachat, Sophie, Struglics, André, Appleton, C Thomas, Kluzek, Stefan, Arden, Nigel K, Felson, David, Marsden, Brian, Tom, Brian D M, Bondi, Laura, Kapoor, Mohit, Batchelor, Vicky, Mackay-Alderson, Jennifer, Kumar, Vinod, Lohmander, L Stefan, Welting, Tim J, Walsh, David A, Valdes, Ana M, Vincent, Tonia L, Watt, Fiona E, Jostins-Dean, Luke

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Comparison of LABORAS with static incapacitance testing for assessing spontaneous pain behaviour in surgically-induced murine osteoarthritis von von Loga, Isabell S., Miotla-Zarebska, Jadwiga, Huang, Yi-Shu, Williams, Richard, Jostins, Luke, Vincent, Tonia L.

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Genetic risk prediction in complex disease von JOSTINS, Luke, BARRETT, Jeffrey C

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Misuse of hierarchical linear models overstates the significance of a reported association between OXTR and prosociality von Jostins, Luke, Pickrell, Joseph K, MacArthur, Daniel G, Barrett, Jeffrey C

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Graphical Model Selection for Gaussian Conditional Random Fields in the Presence of Latent Variables von Frot, Benjamin, Jostins, Luke, McVean, Gilean

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Dispatches from the functional phase of genome biology von Jostins, Luke

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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease von de Lange, Katrina M, Moutsianas, Loukas, Lee, James C, Lamb, Christopher A, Luo, Yang, Kennedy, Nicholas A, Jostins, Luke, Rice, Daniel L, Gutierrez-Achury, Javier, Ji, Sun-Gou, Heap, Graham, Nimmo, Elaine R, Edwards, Cathryn, Henderson, Paul, Mowat, Craig, Sanderson, Jeremy, Satsangi, Jack, Simmons, Alison, Wilson, David C, Tremelling, Mark, Hart, Ailsa, Mathew, Christopher G, Newman, William G, Parkes, Miles, Lees, Charlie W, Uhlig, Holm, Hawkey, Chris, Prescott, Natalie J, Ahmad, Tariq, Mansfield, John C, Anderson, Carl A, Barrett, Jeffrey C

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Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank von Cortes, Adrian, Dendrou, Calliope A, Motyer, Allan, Jostins, Luke, Vukcevic, Damjan, Dilthey, Alexander, Donnelly, Peter, Leslie, Stephen, Fugger, Lars, McVean, Gil

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Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study von Cleynen, Isabelle, PhD, Boucher, Gabrielle, MSc, Jostins, Luke, PhD, Schumm, L Philip, MA, Zeissig, Sebastian, PhD, Ahmad, Tariq, PhD, Andersen, Vibeke, Prof, Andrews, Jane M, Prof, Annese, Vito, MD, Brand, Stephan, Prof, Brant, Steven R, MD, Cho, Judy H, Prof, Daly, Mark J, Prof, Dubinsky, Marla, MD, Duerr, Richard H, Prof, Ferguson, Lynnette R, Prof, Franke, Andre, Prof, Gearry, Richard B, Prof, Goyette, Philippe, PhD, Hakonarson, Hakon, Prof, Halfvarson, Jonas, MD, Hov, Johannes R, PhD, Huang, Hailang, PhD, Kennedy, Nicholas A, PhD, Kupcinskas, Limas, Prof, Lawrance, Ian C, Prof, Lee, James C, PhD, Satsangi, Jack, Prof, Schreiber, Stephan, Prof, Théâtre, Emilie, PhD, van der Meulen-de Jong, Andrea E, MD, Weersma, Rinse K, Prof, Wilson, David C, Prof, Parkes, Miles, PhD, Vermeire, Severine, Prof, Rioux, John D, Prof, Mansfield, John, MD, Silverberg, Mark S, PhD, Radford-Smith, Graham, PhD, McGovern, Dermot P B, Prof, Barrett, Jeffrey C, Dr, Lees, Charlie W, Dr

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An Integrated Taxonomy for Monogenic Inflammatory Bowel Disease von Bolton, Chrissy, Smillie, Christopher S., Pandey, Sumeet, Elmentaite, Rasa, Wei, Gabrielle, Argmann, Carmen, Aschenbrenner, Dominik, James, Kylie R., McGovern, Dermot P.B., Macchi, Marina, Cho, Judy, Shouval, Dror S., Kammermeier, Jochen, Koletzko, Sibylle, Bagalopal, Krithika, Capitani, Melania, Cavounidis, Athena, Pires, Elisabete, Weidinger, Carl, McCullagh, James, Arkwright, Peter D., Haller, Wolfram, Siegmund, Britta, Peters, Lauren, Jostins, Luke, Travis, Simon P.L., Anderson, Carl A., Snapper, Scott, Klein, Christoph, Schadt, Eric, Zilbauer, Matthias, Xavier, Ramnik, Teichmann, Sarah, Muise, Aleixo M., Regev, Aviv, Uhlig, Holm H.

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