Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer von Dow, Lukas E., O’Rourke, Kevin P., Simon, Janelle, Tschaharganeh, Darjus F., van Es, Johan H., Clevers, Hans, Lowe, Scott W.

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A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference von Premsrirut, Prem K., Dow, Lukas E., Kim, Sang Yong, Camiolo, Matthew, Malone, Colin D., Miething, Cornelius, Scuoppo, Claudio, Zuber, Johannes, Dickins, Ross A., Kogan, Scott C., Shroyer, Kenneth R., Sordella, Raffaella, Hannon, Gregory J., Lowe, Scott W.

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Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD von Garcia, Daniel, Hellberg, Kristina, Chaix, Amandine, Wallace, Martina, Herzig, Sébastien, Badur, Mehmet G., Lin, Terry, Shokhirev, Maxim N., Pinto, Antonio F.M., Ross, Debbie S., Saghatelian, Alan, Panda, Satchidananda, Dow, Lukas E., Metallo, Christian M., Shaw, Reuben J.

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Transcriptional plasticity promotes primary and acquired resistance to BET inhibition von Rathert, Philipp, Roth, Mareike, Neumann, Tobias, Muerdter, Felix, Roe, Jae-Seok, Muhar, Matthias, Deswal, Sumit, Cerny-Reiterer, Sabine, Peter, Barbara, Jude, Julian, Hoffmann, Thomas, Boryń, Łukasz M., Axelsson, Elin, Schweifer, Norbert, Tontsch-Grunt, Ulrike, Dow, Lukas E., Gianni, Davide, Pearson, Mark, Valent, Peter, Stark, Alexander, Kraut, Norbert, Vakoc, Christopher R., Zuber, Johannes

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Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets von Tang, Fanying, Xu, Duo, Wang, Shangqian, Wong, Chen Khuan, Martinez-Fundichely, Alexander, Lee, Cindy J, Cohen, Sandra, Park, Jane, Hill, Corinne E, Eng, Kenneth, Bareja, Rohan, Han, Teng, Liu, Eric Minwei, Palladino, Ann, Di, Wei, Gao, Dong, Abida, Wassim, Beg, Shaham, Puca, Loredana, Meneses, Maximiliano, de Stanchina, Elisa, Berger, Michael F, Gopalan, Anuradha, Dow, Lukas E, Mosquera, Juan Miguel, Beltran, Himisha, Sternberg, Cora N, Chi, Ping, Scher, Howard I, Sboner, Andrea, Chen, Yu, Khurana, Ekta

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Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer von O'Rourke, Kevin P, Loizou, Evangelia, Livshits, Geulah, Schatoff, Emma M, Baslan, Timour, Manchado, Eusebio, Simon, Janelle, Romesser, Paul B, Leach, Benjamin, Han, Teng, Pauli, Chantal, Beltran, Himisha, Rubin, Mark A, Dow, Lukas E, Lowe, Scott W

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Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition von Bolden, Jessica E., Tasdemir, Nilgun, Dow, Lukas E., van Es, Johan H., Wilkinson, John E., Zhao, Zhen, Clevers, Hans, Lowe, Scott W.

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R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine von Han, Teng, Schatoff, Emma M., Murphy, Charles, Zafra, Maria Paz, Wilkinson, John E., Elemento, Olivier, Dow, Lukas E.

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Life in the Fast Lane: Mammalian Disease Models in the Genomics Era von Dow, Lukas E., Lowe, Scott W.

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An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants von Zafra, Maria Paz, Parsons, Marie J, Kim, Jangkyung, Alonso-Curbelo, Direna, Goswami, Sukanya, Schatoff, Emma M, Han, Teng, Katti, Alyna, Fernandez, Maria Teresa Calvo, Wilkinson, John E, Piskounova, Elena, Dow, Lukas E

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Engineering chromosome rearrangements in cancer von Alonso, Salvador, Dow, Lukas E

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Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice von Dow, Lukas E, Nasr, Zeina, Saborowski, Michael, Ebbesen, Saya H, Manchado, Eusebio, Tasdemir, Nilgun, Lee, Teresa, Pelletier, Jerry, Lowe, Scott W

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Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer von Morral, Clara, Stanisavljevic, Jelena, Hernando-Momblona, Xavier, Mereu, Elisabetta, Álvarez-Varela, Adrián, Cortina, Carme, Stork, Diana, Slebe, Felipe, Turon, Gemma, Whissell, Gavin, Sevillano, Marta, Merlos-Suárez, Anna, Casanova-Martí, Àngela, Moutinho, Catia, Lowe, Scott W., Dow, Lukas E., Villanueva, Alberto, Sancho, Elena, Heyn, Holger, Batlle, Eduard

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p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer von Tschaharganeh, Darjus F., Xue, Wen, Calvisi, Diego F., Evert, Matthias, Michurina, Tatyana V., Dow, Lukas E., Banito, Ana, Katz, Sarah F., Kastenhuber, Edward R., Weissmueller, Susann, Huang, Chun-Hao, Lechel, Andre, Andersen, Jesper B., Capper, David, Zender, Lars, Longerich, Thomas, Enikolopov, Grigori, Lowe, Scott W.

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Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition von Schatoff, Emma M, Goswami, Sukanya, Zafra, Maria Paz, Foronda, Miguel, Shusterman, Michael, Leach, Benjamin I, Katti, Alyna, Diaz, Bianca J, Dow, Lukas E

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Lineage Reversion Drives WNT Independence in Intestinal Cancer von Han, Teng, Goswami, Sukanya, Hu, Yang, Tang, Fanying, Zafra, Maria Paz, Murphy, Charles, Cao, Zhen, Poirier, John T, Khurana, Ekta, Elemento, Olivier, Hechtman, Jaclyn F, Ganesh, Karuna, Yaeger, Rona, Dow, Lukas E

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Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy von Hinze, Laura, Labrosse, Roxane, Degar, James, Han, Teng, Schatoff, Emma M, Schreek, Sabine, Karim, Salmaan, McGuckin, Connor, Sacher, Joshua R, Wagner, Florence, Stanulla, Martin, Yuan, Chen, Sicinska, Ewa, Giannakis, Marios, Ng, Kimmie, Dow, Lukas E, Gutierrez, Alejandro

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Modeling Disease In Vivo With CRISPR/Cas9 von Dow, Lukas E

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WNT as a Driver and Dependency in Cancer von Parsons, Marie J, Tammela, Tuomas, Dow, Lukas E

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Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas von Ebbesen, Saya H., Scaltriti, Maurizio, Bialucha, Carl U., Morse, Natasha, Kastenhuber, Edward R., Wen, Hannah Y., Dow, Lukas E., Baselga, José, Lowe, Scott W.

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