MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM von Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin

Volltext

Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies von Harms, Brian D., Kearns, Jeffrey D., Iadevaia, Sergio, Lugovskoy, Alexey A.

Volltext

Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics von Geddie, Melissa L, Kirpotin, Dmitri B, Kohli, Neeraj, Kornaga, Tad, Boll, Bjoern, Razlog, Maja, Drummond, Daryl C, Lugovskoy, Alexey A

Volltext

Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E von Gross, John D., Moerke, Nathan J., von der Haar, Tobias, Lugovskoy, Alexey A., Sachs, Alan B., McCarthy, John E.G., Wagner, Gerhard

Volltext

Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysin... von Shi, Xiaobing, Kachirskaia, Ioulia, Walter, Kay L., Kuo, Jen-Hao A., Lake, Aimee, Davrazou, Foteini, Chan, Steve M., Martin, David G.E., Fingerman, Ian M., Briggs, Scott D., Howe, LeAnn, Utz, Paul J., Kutateladze, Tatiana G., Lugovskoy, Alexey A., Bedford, Mark T., Gozani, Or

Volltext

Fast screening of protein surfaces using geometric invariant fingerprints von Yin, Shuangye, Proctor, Elizabeth A, Lugovskoy, Alexey A, Dokholyan, Nikolay V

Volltext

Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle von Zhang, Kathy, Geddie, Melissa L, Kohli, Neeraj, Kornaga, Tad, Kirpotin, Dmitri B, Jiao, Yang, Rennard, Rachel, Drummond, Daryl C, Nielsen, Ulrik B, Xu, Lihui, Lugovskoy, Alexey A

Volltext

Conserved amino acid networks involved in antibody variable domain interactions von Wang, Norman, Smith, William F., Miller, Brian R., Aivazian, Dikran, Lugovskoy, Alexey A., Reff, Mitchell E., Glaser, Scott M., Croner, Lisa J., Demarest, Stephen J.

Volltext

A novel screening method to assess developability of antibody-like molecules von Kohli, Neeraj, Jain, Nidhi, Geddie, Melissa L, Razlog, Maja, Xu, Lihui, Lugovskoy, Alexey A

Volltext

A Novel Approach for Characterizing Protein Ligand Complexes:  Molecular Basis for Specificity of Small-Molecule Bcl-2 Inhibitors von Lugovskoy, Alexey A, Degterev, Alexei I, Fahmy, Amr F, Zhou, Pei, Gross, John D, Yuan, Junying, Wagner, Gerhard

Volltext

MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors von Fitzgerald, Jonathan B, Johnson, Bryan W, Baum, Jason, Adams, Sharlene, Iadevaia, Sergio, Tang, Jian, Rimkunas, Victoria, Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Razlog, Maja, Jiao, Yang, Harms, Brian D, Olivier, Jr, Kenneth J, Schoeberl, Birgit, Nielsen, Ulrik B, Lugovskoy, Alexey A

Volltext

Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer von Camblin, Adam J, Pace, Emily A, Adams, Sharlene, Curley, Michael D, Rimkunas, Victoria, Nie, Lin, Tan, Gege, Bloom, Troy, Iadevaia, Sergio, Baum, Jason, Minx, Charlene, Czibere, Akos, Louis, Chrystal U, Drummond, Daryl C, Nielsen, Ulrik B, Schoeberl, Birgit, Pipas, J Marc, Straubinger, Robert M, Askoxylakis, Vasileios, Lugovskoy, Alexey A

Volltext

Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer von Camblin, Adam J., Tan, Gege, Curley, Michael D., Yannatos, Isabel, Iadevaia, Sergio, Rimkunas, Victoria, Mino-Kenudson, Mari, Bloom, Troy, Schoeberl, Birgit, Drummond, Daryl C., Lugovskoy, Alexey A., Louis, Chrystal U., Askoxylakis, Vasileios

Volltext

Solution Structure of DFF40 and DFF45 N-Terminal Domain Complex and Mutual Chaperone Activity of DFF40 and DFF45 von Zhou, Pei, Lugovskoy, Alexey A., McCarty, John S., Li, Peng, Wagner, Gerhard

Volltext

7th Annual European Antibody Congress 2011: November 29–December 1, 2011, Geneva, Switzerland von Lugovskoy, Alexey A, Reichert, Janice M, Beck, Alain

Volltext

Solution Structure of the CIDE-N Domain of CIDE-B and a Model for CIDE-N/CIDE-N Interactions in the DNA Fragmentation Pathway of Apoptosis von Lugovskoy, Alexey A, Zhou, Pei, Chou, James J, McCarty, John S, Li, Peng, Wagner, Gerhard

Volltext

De novo discovery of antibody drugs - great promise demands scrutiny von Finlay, William J.J., Lugovskoy, Alexey A.

Volltext

Small-Molecule Inhibition of TNF-α von He, Molly M., Smith, Annemarie Stroustrup, Oslob, Johan D., Flanagan, William M., Braisted, Andrew C., Whitty, Adrian, Cancilla, Mark T., Wang, Jun, Lugovskoy, Alexey A., Yoburn, Josh C., Fung, Amy D., Farrington, Graham, Eldredge, John K., Day, Eric S., Cruz, Leslie A., Cachero, Teresa G., Miller, Stephan K., Friedman, Jessica E., Choong, Ingrid C., Cunningham, Brian C.

Volltext

The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor von Gozani, Or, Karuman, Philip, Jones, David R., Ivanov, Dmitri, Cha, James, Lugovskoy, Alexey A., Baird, Cheryl L., Zhu, Hong, Field, Seth J., Lessnick, Stephen L., Villasenor, Jennifer, Mehrotra, Bharat, Chen, Jian, Rao, Vikram R., Brugge, Joan S., Ferguson, Colin G., Payrastre, Bernard, Myszka, David G., Cantley, Lewis C., Wagner, Gerhard, Divecha, Nullin, Prestwich, Glenn D., Yuan, Junying

Volltext

Rational engineering of antibody therapeutics targeting multiple oncogene pathways von Fitzgerald, Jonathan, Lugovskoy, Alexey A.

Volltext