Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies von WONG, P. C., CRAIN, E. J., XIN, B., WEXLER, R. R., LAM, P. Y. S., PINTO, D. J., LUETTGEN, J. M., KNABB, R. M.

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Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, an... von Pinto, Donald J. P, Orwat, Michael J, Wang, Shuaige, Fevig, John M, Quan, Mimi L, Amparo, Eugene, Cacciola, Joseph, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela M, Luettgen, Joseph M, Liang, Li, Aungst, Bruce J, Wright, Matthew R, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R, Lam, Patrick Y. S

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Design, Synthesis, and Biological Evaluation of Potent and Selective Amidino Bicyclic Factor Xa Inhibitors von Han, Qi, Dominguez, Celia, Stouten, Pieter F. W, Park, Jeongsook M, Duffy, Daniel E, Galemmo, Robert A, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela M, Wong, Pancras C, Wright, Matthew M, Luettgen, Joseph M, Knabb, Robert M, Wexler, Ruth R

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BMS-593214, an active site-directed factor VIIa inhibitor: Enzyme kinetics, antithrombotic and antihaemostatic studies von Wong, Pancras C., Luettgen, Joseph M., Rendina, Alan R., Kettner, Charles A., Xin, Baomin, Knabb, Robert M., Wexler, Ruth R., Priestley, E. Scott

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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a... von Quan, Mimi L, Lam, Patrick Y. S, Han, Qi, Pinto, Donald J. P, He, Ming Y, Li, Renhua, Ellis, Christopher D, Clark, Charles G, Teleha, Christopher A, Sun, Jung-Hui, Alexander, Richard S, Bai, Steve, Luettgen, Joseph M, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R

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Structure-Based Design of Novel Guanidine/Benzamidine Mimics:  Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants von Lam, Patrick Y. S, Clark, Charles G, Li, Renhua, Pinto, Donald J. P, Orwat, Michael J, Galemmo, Robert A, Fevig, John M, Teleha, Christopher A, Alexander, Richard S, Smallwood, Angela M, Rossi, Karen A, Wright, Matthew R, Bai, Stephen A, He, Kan, Luettgen, Joseph M, Wong, Pancras C, Knabb, Robert M, Wexler, Ruth R

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5-Amidinobenzo[ b]thiophenes as dual inhibitors of factors IXa and Xa von Qiao, Jennifer X., Cheng, Xuhong, Modi, Dilip P., Rossi, Karen A., Luettgen, Joseph M., Knabb, Robert M., Jadhav, Prabhakar K., Wexler, Ruth R.

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Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in rats von XINKANG WANG, LIN XU, BERNARD, Roberta, VARGAS, Hugo, CHOPP, Michael, FRIEDMAN, Steven M, FEUERSTEIN, Giora Z, WANG, Hugh, GRZANNA, Reinhard, YUTIAN ZHAN, KNABB, Robert M, LUETTGEN, Joseph M, BOZARTH, Tracy A, GALEMMO, Robert A, WONG, Pancras C

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SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa von SMALLHEER, Joanne M, ALEXANDER, Richard S, KNABB, Robert M, WEXLER, Ruth R, JADHAV, Prabhakar K, JIANMIN WANG, SHUAIGE WANG, NAKAJIMA, Suanne, ROSSI, Karen A, SMALLWOOD, Angela, BARBERA, Frank, BURDICK, Debra, LUETTGEN, Joseph M

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Discovery of 3-Amino-4-Chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library von Lam, Patrick Y.S., Adams, Jessica J., Clark, Charles G., Calhoun, W.Jason, Luettgen, Joseph M., Knabb, Robert M., Wexler, Ruth R.

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Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors von Quan, Mimi L., Han, Qi, Fevig, John M., Lam, Patrick Y.S., Bai, Steve, Knabb, Robert M., Luettgen, Joseph M., Wong, Pancras C., Wexler, Ruth R.

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5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa von Batt, Douglas G, Qiao, Jennifer X, Modi, Dilip P, Houghton, Gregory C, Pierson, Deborah A, Rossi, Karen A, Luettgen, Joseph M, Knabb, Robert M, Jadhav, P K, Wexler, Ruth R

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Nonbenzamidine tetrazole derivatives as factor Xa inhibitors von Quan, Mimi L, Ellis, Christopher D, He, Ming Y, Liauw, Ann Y, Woerner, Francis J, Alexander, Richard S, Knabb, Robert M, Lam, Patrick Y.S, Luettgen, Joseph M, Wong, Pancras C, Wright, Matthew R, Wexler, Ruth R

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Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors von Quan, Mimi L., Ellis, Christopher D., He, Ming Y., Liauw, Ann Y., Lam, Patrick Y.S., Rossi, Karen A., Knabb, Robert M., Luettgen, Joseph M., Wright, Matthew R., Wong, Pancras C., Wexler, Ruth R.

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Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and... von Pinto, D J, Orwat, M J, Wang, S, Fevig, J M, Quan, M L, Amparo, E, Cacciola, J, Rossi, K A, Alexander, R S, Smallwood, A M, Luettgen, J M, Liang, L, Aungst, B J, Wright, M R, Knabb, R M, Wong, P C, Wexler, R R, Lam, P Y

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Milvexian, an orally bioavailable, small‐molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits von Wong, Pancras C., Crain, Earl J., Bozarth, Jeffrey M., Wu, Yiming, Dilger, Andrew K., Wexler, Ruth R., Ewing, William R., Gordon, David, Luettgen, Joseph M.

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Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212) von Pinto, Donald J. P., Orwat, Michael J., Smith, Leon M., Quan, Mimi L., Lam, Patrick Y. S., Rossi, Karen A., Apedo, Atsu, Bozarth, Jeffrey M., Wu, Yiming, Zheng, Joanna J., Xin, Baomin, Toussaint, Nathalie, Stetsko, Paul, Gudmundsson, Olafur, Maxwell, Brad, Crain, Earl J., Wong, Pancras C., Lou, Zhen, Harper, Timothy W., Chacko, Silvi A., Myers, Joseph E., Sheriff, Steven, Zhang, Huiping, Hou, Xiaoping, Mathur, Arvind, Seiffert, Dietmar A., Wexler, Ruth R., Luettgen, Joseph M., Ewing, William R.

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Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitro von Jiang, Xiaosui, Crain, Earl J., Luettgen, Joseph M., Schumacher, William A., Wong, Pancras C.

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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selec... von Pinto, Donald J. P, Orwat, Michael J, Koch, Stephanie, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela, Wong, Pancras C, Rendina, Alan R, Luettgen, Joseph M, Knabb, Robert M, He, Kan, Xin, Baomin, Wexler, Ruth R, Lam, Patrick Y. S

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Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy von Dilger, Andrew K, Pabbisetty, Kumar B, Corte, James R, De Lucca, Indawati, Fang, Tianan, Yang, Wu, Pinto, Donald J. P, Wang, Yufeng, Zhu, Yeheng, Mathur, Arvind, Li, Jianqing, Hou, Xiaoping, Smith, Daniel, Sun, Dawn, Zhang, Huiping, Krishnananthan, Subramaniam, Wu, Dauh-Rurng, Myers, Joseph E, Sheriff, Steven, Rossi, Karen A, Chacko, Silvi, Zheng, Joanna J, Galella, Michael A, Ziemba, Theresa, Dierks, Elizabeth A, Bozarth, Jeffrey M, Wu, Yiming, Crain, Earl, Wong, Pancras C, Luettgen, Joseph M, Wexler, Ruth R, Ewing, William R

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