Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research von D'Adamio, Luciano

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Opposite changes in APP processing and human A beta levels in rats carrying either a protective or a pathogenic APP mutation von Tambini, Marc D., Norris, Kelly A., D'Adamio, Luciano

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Initial assessment of the spatial learning, reversal, and sequencing task capabilities of knock-in rats with humanizing mutations in the Aβ-coding region of App von Pham, Hoa, Yin, Tao, D'Adamio, Luciano

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LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent von Puzzo, Daniela, Piacentini, Roberto, Fá, Mauro, Gulisano, Walter, Li Puma, Domenica D, Staniszewski, Agnes, Zhang, Hong, Tropea, Maria Rosaria, Cocco, Sara, Palmeri, Agostino, Fraser, Paul, D'Adamio, Luciano, Grassi, Claudio, Arancio, Ottavio

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Beyond amyloid: altered gene function in neurodegenerative diseases von Yesiltepe, Metin, Yin, Tao, D’Adamio, Luciano

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Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock‐in rats with increased β‐cleavage of APP von Tambini, Marc D., Yao, Wen, D'Adamio, Luciano

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Microglia TREM2(R47H) Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-alpha levels von Ren, Siqiang, Yao, Wen, Tambini, Marc D., Yin, Tao, Norris, Kelly A., D'Adamio, Luciano

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APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesic... von Del Prete, Dolores, Lombino, Franco, Liu, Xinran, D'Adamio, Luciano

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Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling von Cipolat, Sara, Rudka, Tomasz, Hartmann, Dieter, Costa, Veronica, Serneels, Lutgarde, Craessaerts, Katleen, Metzger, Kristine, Frezza, Christian, Annaert, Wim, D'Adamio, Luciano, Derks, Carmen, Dejaegere, Tim, Pellegrini, Luca, D'Hooge, Rudi, Scorrano, Luca, De Strooper, Bart

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APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses von Fanutza, Tomas, Del Prete, Dolores, Ford, Michael J, Castillo, Pablo E, D'Adamio, Luciano

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Intracellular accumulation of tau oligomers in astrocytes and their synaptotoxic action rely on Amyloid Precursor Protein Intracellular Domain-dependent expression of Glypican-4 von Puliatti, Giulia, Li Puma, Domenica Donatella, Aceto, Giuseppe, Lazzarino, Giacomo, Acquarone, Erica, Mangione, Renata, D'Adamio, Luciano, Ripoli, Cristian, Arancio, Ottavio, Piacentini, Roberto, Grassi, Claudio

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Reply to Johansson ‘Treatment with BRICHOS domain helps to clarify issues with Alzheimer mouse models’ von D’Adamio, Luciano

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Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Transla... von Bavley, Charlotte C, Rice, Richard C, Fischer, Delaney K, Fakira, Amanda K, Byrne, Maureen, Kosovsky, Maria, Rizzo, Bryant K, Del Prete, Dolores, Alaedini, Armin, Morón, Jose A, Higgins, Joseph J, D'Adamio, Luciano, Rajadhyaksha, Anjali M

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Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels von Ren, Siqiang, Yao, Wen, Tambini, Marc D, Yin, Tao, Norris, Kelly A, D'Adamio, Luciano

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Tau is not necessary for amyloid-beta-induced synaptic and memory impairments von Puzzo, Daniela, Argyrousi, Elentina K., Staniszewski, Agnieszka, Zhang, Hong, Calcagno, Elisa, Zuccarello, Elisa, Acquarone, Erica, Fa', Mauro, Li Puma, Domenica D., Grassi, Claudio, D'Adamio, Luciano, Kanaan, Nicholas M., Fraser, Paul E., Arancio, Ottavio

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Late-long-term potentiation magnitude, but not Aβ levels and amyloid pathology, is associated with behavioral performance in a rat knock-in model of Alzheimer disease von Yesiltepe, Metin, Yin, Tao, Tambini, Marc D., Breuillaud, Lionel, Zehntner, Simone P., D’Adamio, Luciano

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Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits von Tamayev, Robert, Matsuda, Shuji, Fà, Mauro, Arancio, Ottavio, D'Adamio, Luciano, Südhof, Thomas C.

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BRI3 Inhibits Amyloid Precursor Protein Processing in a Mechanistically Distinct Manner from Its Homologue Dementia Gene BRI2 von Matsuda, Shuji, Matsuda, Yukiko, D'Adamio, Luciano

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The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains von Tamayev, Robert, Zhou, Dawang, D'Adamio, Luciano

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A role for tau in learning, memory and synaptic plasticity von Biundo, Fabrizio, Del Prete, Dolores, Zhang, Hong, Arancio, Ottavio, D’Adamio, Luciano

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