Put a ring on it: application of small aliphatic rings in medicinal chemistry von Bauer, Matthias R, Di Fruscia, Paolo, Lucas, Simon C. C, Michaelides, Iacovos N, Nelson, Jennifer E, Storer, R. Ian, Whitehurst, Benjamin C

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Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors von Lucas, Simon C. C, Atkinson, Stephen J, Chung, Chun-wa, Davis, Rob, Gordon, Laurie, Grandi, Paola, Gray, James J. R, Grimes, Thomas, Phillipou, Alexander, Preston, Alex G, Prinjha, Rab K, Rioja, Inmaculada, Taylor, Simon, Tomkinson, Nicholas C. O, Wall, Ian, Watson, Robert J, Woolven, James, Demont, Emmanuel H

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Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode von Lucas, Simon C. C, Atkinson, Stephen J, Bamborough, Paul, Barnett, Heather, Chung, Chun-wa, Gordon, Laurie, Mitchell, Darren J, Phillipou, Alexander, Prinjha, Rab K, Sheppard, Robert J, Tomkinson, Nicholas C. O, Watson, Robert J, Demont, Emmanuel H

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Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines von Alamillo-Ferrer, Carla, Curle, Jonathan M, Davidson, Stuart C, Lucas, Simon C. C, Atkinson, Stephen J, Campbell, Matthew, Kennedy, Alan R, Tomkinson, Nicholas C. O

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A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification von Bamborough, Paul, Chung, Chun-wa, Demont, Emmanuel H, Bridges, Angela M, Craggs, Peter D, Dixon, David P, Francis, Peter, Furze, Rebecca C, Grandi, Paola, Jones, Emma J, Karamshi, Bhumika, Locke, Kelly, Lucas, Simon C. C, Michon, Anne-Marie, Mitchell, Darren J, Pogány, Peter, Prinjha, Rab K, Rau, Christina, Roa, Ana Maria, Roberts, Andrew D, Sheppard, Robert J, Watson, Robert J

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Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates von Jones, S. Paul, Firth, James D, Wheldon, Mary C, Atobe, Masakazu, Hubbard, Roderick E, Blakemore, David C, De Fusco, Claudia, Lucas, Simon C. C, Roughley, Stephen D, Vidler, Lewis R, Whatton, Maria Ann, Woolford, Alison J.-A, Wrigley, Gail L, O'Brien, Peter

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Synthesis of Benzothiazinones from Benzoyl Thiocarbamates: Application to Clinical Candidates for Tuberculosis Treatment von Connors, William, DeKorte, Ryan, Lucas, Simon C. C., Gopalsamy, Ariamala, Ziegler, Robert E.

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Hit me with your best shot: Integrated hit discovery for the next generation of drug targets von Ashraf, S. Neha, Blackwell, J. Henry, Holdgate, Geoffrey A., Lucas, Simon C.C., Solovyeva, Alisa, Storer, R. Ian, Whitehurst, Benjamin C.

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Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders von Lucas, Simon C. C., Ahmed, Afshan, Ashraf, S. Neha, Argyrou, Argyrides, Bauer, Matthias R., De Donatis, Gian Marco, Demanze, Sylvain, Eisele, Frederik, Fusani, Lucia, Hock, Andreas, Kadamur, Ganesh, Li, Shuyou, Macmillan-Jones, Abigail, Michaelides, Iacovos N., Phillips, Christopher, Rehnström, Marie, Richter, Magdalena, Rodrigo-Brenni, Monica C., Shilliday, Fiona, Wang, Peng, Storer, R. Ian

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Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1 von Lucas, Simon C. C., Milbradt, Alexander G., Blackwell, J. Henry, Bonomo, Silvia, Brierley, Andrew, Cassar, Doyle J., Freeman, Jared, Hadfield, Thomas E., Morrill, Lucas A., Riemens, Rick, Sarda, Sunil, Schiesser, Stefan, Wiktelius, Daniel, Ahmed, Samiyah, Bostock, Mark J., Börjesson, Ulf, De Fusco, Claudia, Guerot, Carine, Hargreaves, David, Hewitt, Sarah, Lamb, Michelle L., Su, Nancy, Whatling, Ryan, Wheeler, Matthew, Kettle, Jason G.

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Structure-Based Optimization of a Series of Covalent, Cell Active Bfl‑1 Inhibitors von Lucas, Simon C. C., Blackwell, J. Henry, Börjesson, Ulf, Hargreaves, David, Milbradt, Alexander G., Bostock, Mark J., Ahmed, Samiyah, Beaumont, Kevin, Cheung, Tony, Demanze, Sylvain, Gohlke, Andrea, Guerot, Carine, Haider, Afreen, Kantae, Vasudev, Kauffman, Gregory W., Kinzel, Olaf, Kupcova, Lea, Lainchbury, Michael D., Lamb, Michelle L., Leon, Leonardo, Palisse, Adeline, Sacchetto, Claudia, Storer, R. Ian, Su, Nancy, Thomson, Clare, Vales, John, Chen, Yunhua, Hu, Xiaolong

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Covalent hits and where to find them von Lucas, Simon C.C., Blackwell, J. Henry, Hewitt, Sarah H., Semple, Hannah, Whitehurst, Benjamin C., Xu, Hua

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Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl‑1 from a DNA-Encoded Chemical Library Screen von Lucas, Simon C. C., Blackwell, J. Henry, Börjesson, Ulf, Hargreaves, David, Milbradt, Alexander G., Ahmed, Samiyah, Bostock, Mark J., Guerot, Carine, Gohlke, Andrea, Kinzel, Olaf, Lamb, Michelle L., Selmi, Nidhal, Stubbs, Christopher J., Su, Nancy, Su, Qibin, Luo, Haiou, Xiong, Ting, Zuo, Xiaoqian, Bazzaz, Sana, Bienstock, Corey, Centrella, Paolo A., Denton, Kyle E., Gikunju, Diana, Guié, Marie-Aude, Guilinger, John P., Hupp, Christopher, Keefe, Anthony D., Satoh, Takashi, Zhang, Ying, Rivers, Emma L.

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Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors von Palisse, Adeline, Cheung, Tony, Blokhuis, Aileen, Cogswell, Thomas, Martins, Bruna S, Riemens, Rick, Schellekens, Rick, Battocchio, Giovanni, Jansen, Chimed, Cottee, Matthew A, Ornell, Kimberly, Sacchetto, Claudia, Leon, Leonardo, van Hoek-Emmelot, Maaike, Bostock, Mark, Brauer, Brooke Leann, Beaumont, Kevin, Lucas, Simon C C, Ahmed, Samiyah, Blackwell, J Henry, Börjesson, Ulf, Gohlke, Andrea, Gramatikov, Iva Monique T, Hargreaves, David, van Hoeven, Vera, Kantae, Vasudev, Kupcova, Lea, Milbradt, Alexander G, Seneviratne, Uthpala, Su, Nancy, Vales, John, Wang, Haiyun, White, Michael J, Kinzel, Olaf

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In Vitro Evidence Supports Membrane Alanyl Aminopeptidase N as a Receptor for a Plant Virus in the Pea Aphid Vector von Linz, Lucas B, Liu, Sijun, Chougule, Nanasaheb P, Bonning, Bryony C

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Attention Strongly Modulates Reliability of Neural Responses to Naturalistic Narrative Stimuli von Ki, Jason J, Kelly, Simon P, Parra, Lucas C

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Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus von Kraemer, Moritz U. G., Reiner, Robert C., Brady, Oliver J., Messina, Jane P., Gilbert, Marius, Pigott, David M., Yi, Dingdong, Johnson, Kimberly, Earl, Lucas, Marczak, Laurie B., Shirude, Shreya, Davis Weaver, Nicole, Bisanzio, Donal, Perkins, T. Alex, Lai, Shengjie, Lu, Xin, Jones, Peter, Coelho, Giovanini E., Carvalho, Roberta G., Van Bortel, Wim, Marsboom, Cedric, Hendrickx, Guy, Schaffner, Francis, Moore, Chester G., Nax, Heinrich H., Bengtsson, Linus, Wetter, Erik, Tatem, Andrew J., Brownstein, John S., Smith, David L., Lambrechts, Louis, Cauchemez, Simon, Linard, Catherine, Faria, Nuno R., Pybus, Oliver G., Scott, Thomas W., Liu, Qiyong, Yu, Hongjie, Wint, G. R. William, Hay, Simon I., Golding, Nick

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Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings von Lafon, Belen, Henin, Simon, Huang, Yu, Friedman, Daniel, Melloni, Lucia, Thesen, Thomas, Doyle, Werner, Buzsáki, György, Devinsky, Orrin, Parra, Lucas C., A. Liu, Anli

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EEG in the classroom: Synchronised neural recordings during video presentation von Poulsen, Andreas Trier, Kamronn, Simon, Dmochowski, Jacek, Parra, Lucas C., Hansen, Lars Kai

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B cell zone reticular cell microenvironments shape CXCL13 gradient formation von Cosgrove, Jason, Novkovic, Mario, Albrecht, Stefan, Pikor, Natalia B., Zhou, Zhaoukun, Onder, Lucas, Mörbe, Urs, Cupovic, Jovana, Miller, Helen, Alden, Kieran, Thuery, Anne, O’Toole, Peter, Pinter, Rita, Jarrett, Simon, Taylor, Emily, Venetz, Daniel, Heller, Manfred, Uguccioni, Mariagrazia, Legler, Daniel F., Lacey, Charles J., Coatesworth, Andrew, Polak, Wojciech G., Cupedo, Tom, Manoury, Bénedicte, Thelen, Marcus, Stein, Jens V., Wolf, Marlene, Leake, Mark C., Timmis, Jon, Ludewig, Burkhard, Coles, Mark C.

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