LGR5 marks targetable tumor-initiating cells in mouse liver cancer von Cao, Wanlu, Li, Meng, Liu, Jiaye, Zhang, Shaoshi, Noordam, Lisanne, Verstegen, Monique M. A., Wang, Ling, Ma, Buyun, Li, Shan, Wang, Wenshi, Bolkestein, Michiel, Doukas, Michael, Chen, Kan, Ma, Zhongren, Bruno, Marco, Sprengers, Dave, Kwekkeboom, Jaap, van der Laan, Luc J. W., Smits, Ron, Peppelenbosch, Maikel P., Pan, Qiuwei

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Tissue-specific mutation accumulation in human adult stem cells during life von Blokzijl, Francis, de Ligt, Joep, Jager, Myrthe, Sasselli, Valentina, Roerink, Sophie, Sasaki, Nobuo, Huch, Meritxell, Boymans, Sander, Kuijk, Ewart, Prins, Pjotr, Nijman, Isaac J., Martincorena, Inigo, Mokry, Michal, Wiegerinck, Caroline L., Middendorp, Sabine, Sato, Toshiro, Schwank, Gerald, Nieuwenhuis, Edward E. S., Verstegen, Monique M. A., van der Laan, Luc J. W., de Jonge, Jeroen, IJzermans, Jan N. M., Vries, Robert G., van de Wetering, Marc, Stratton, Michael R., Clevers, Hans, Cuppen, Edwin, van Boxtel, Ruben

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Prime editing for functional repair in patient-derived disease models von Schene, Imre F., Joore, Indi P., Oka, Rurika, Mokry, Michal, van Vugt, Anke H. M., van Boxtel, Ruben, van der Doef, Hubert P. J., van der Laan, Luc J. W., Verstegen, Monique M. A., van Hasselt, Peter M., Nieuwenhuis, Edward E. S., Fuchs, Sabine A.

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Scaffolds obtained from decellularized human extrahepatic bile ducts support organoids to establish functional biliary tissue in a dish von Willemse, Jorke, Roos, Floris J. M., Voogt, Iris J., Schurink, Ivo J., Bijvelds, Marcel, Jonge, Hugo R., Laan, Luc J. W., Jonge, Jeroen, Verstegen, Monique M. A.

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Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids von Krüger, Melanie, Oosterhoff, Loes A., van Wolferen, Monique E., Schiele, Simon A., Walther, Andreas, Geijsen, Niels, De Laporte, Laura, van der Laan, Luc J. W., Kock, Linda M., Spee, Bart

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Scalable Production of Size-Controlled Cholangiocyte and Cholangiocarcinoma Organoids within Liver Extracellular Matrix-Containing Microcapsules von van Tienderen, Gilles S, Willemse, Jorke, van Loo, Bas, van Hengel, Eline V A, de Jonge, Jeroen, van der Laan, Luc J W, Leijten, Jeroen, Verstegen, Monique M A

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Label-Free Imaging Analysis of Patient-Derived Cholangiocarcinoma Organoids after Sorafenib Treatment von Koch, Michael, Nickel, Sandra, Lieshout, Ruby, Lissek, Susanna M, Leskova, Martina, van der Laan, Luc J W, Verstegen, Monique M A, Christ, Bruno, Pampaloni, Francesco

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Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi) von Pan, Qiuwei, Ramakrishnaiah, Vedashree, Henry, Scot, Fouraschen, Suomi, de Ruiter, Petra E, Kwekkeboom, Jaap, Tilanus, Hugo W, Janssen, Harry L A, van der Laan, Luc J W

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Evaluation of RNA isolation methods for microRNA quantification in a range of clinical biofluids von Roest, Henk P, IJzermans, Jan N M, van der Laan, Luc J W

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Cross Talk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication von Wang, Yijin, Wang, Wenshi, Xu, Lei, Zhou, Xinying, Shokrollahi, Ehsan, Felczak, Krzysztof, van der Laan, Luc J W, Pankiewicz, Krzysztof W, Sprengers, Dave, Raat, Nicolaas J H, Metselaar, Herold J, Peppelenbosch, Maikel P, Pan, Qiuwei

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Experimental models to unravel the molecular pathogenesis, cell of origin and stem cell properties of cholangiocarcinoma von Vicent, Silvestre, Lieshout, Ruby, Saborowski, Anna, Verstegen, Monique M. A., Raggi, Chiara, Recalcati, Stefania, Invernizzi, Pietro, Laan, Luc J. W., Alvaro, Domenico, Calvisi, Diego F., Cardinale, Vincenzo

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A proof of concept study on real-time LiMAx CYP1A2 liver function assessment of donor grafts during normothermic machine perfusion von Schurink, Ivo J., de Haan, Jubi E., Willemse, Jorke, Mueller, Matteo, Doukas, Michael, Roest, Henk, de Goeij, Femke H. C., Polak, Wojciech G., Ijzermans, Jan N. M., Dutkowski, Philipp, van der Laan, Luc J. W., de Jonge, Jeroen

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Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth von Li, Meng, Wang, Ling, Wang, Yijin, Zhang, Shaoshi, Zhou, Guoying, Lieshout, Ruby, Ma, Buyun, Liu, Jiaye, Qu, Changbo, Verstegen, Monique M A, Sprengers, Dave, Kwekkeboom, Jaap, van der Laan, Luc J W, Cao, Wanlu, Peppelenbosch, Maikel P, Pan, Qiuwei

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Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver‐Like Metabolic Biofactories von Bernal, Paulina Nuñez, Bouwmeester, Manon, Madrid‐Wolff, Jorge, Falandt, Marc, Florczak, Sammy, Rodriguez, Nuria Ginés, Li, Yang, Größbacher, Gabriel, Samsom, Roos‐Anne, van Wolferen, Monique, van der Laan, Luc J. W., Delrot, Paul, Loterie, Damien, Malda, Jos, Moser, Christophe, Spee, Bart, Levato, Riccardo

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A Chemically Defined Hydrogel for Human Liver Organoid Culture von Ye, Shicheng, Boeter, Jochem W.B., Mihajlovic, Marko, Steenbeek, Frank G., Wolferen, Monique E., Oosterhoff, Loes A., Marsee, Ary, Caiazzo, Massimiliano, Laan, Luc J.W., Penning, Louis C., Vermonden, Tina, Spee, Bart, Schneeberger, Kerstin

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Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing von Bouwmeester, Manon C, Tao, Yu, Proença, Susana, van Steenbeek, Frank G, Samsom, Roos-Anne, Nijmeijer, Sandra M, Sinnige, Theo, van der Laan, Luc J W, Legler, Juliette, Schneeberger, Kerstin, Kramer, Nynke I, Spee, Bart

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Impact of hypoxia and AMPK on CFTR-mediated bicarbonate secretion in human cholangiocyte organoids von Roos, Floris J M, Bijvelds, Marcel J C, Verstegen, Monique M A, Roest, Henk P, Metselaar, Herold J, Polak, Wojciech G, Jonge, Hugo R de, IJzermans, Jan N M, Laan, Luc J W van der

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Kinome profiling of cholangiocarcinoma organoids reveals potential druggable targets that hold promise for treatment stratification von Lieshout, Ruby, Faria, Alessandra V. S., Peppelenbosch, Maikel P., van der Laan, Luc J. W., Verstegen, Monique M. A., Fuhler, Gwenny M.

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Cholangiocyte organoids to study drug-induced injury von Wang, Zhenguo, Xing, Chen, van der Laan, Luc J W, Verstegen, Monique M A, Spee, Bart, Masereeuw, Rosalinde

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Mycophenolic acid augments interferon-stimulated gene expression and inhibits hepatitis C Virus infection in vitro and in vivo von Pan, Qiuwei, de Ruiter, Petra E., Metselaar, Herold J., Kwekkeboom, Jaap, de Jonge, Jeroen, Tilanus, Hugo W., Janssen, Harry L.A., van der Laan, Luc J.W.

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