Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer von Dow, Lukas E., O’Rourke, Kevin P., Simon, Janelle, Tschaharganeh, Darjus F., van Es, Johan H., Clevers, Hans, Lowe, Scott W.

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Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway von Freed-Pastor, William A., Mizuno, Hideaki, Zhao, Xi, Langerød, Anita, Moon, Sung-Hwan, Rodriguez-Barrueco, Ruth, Barsotti, Anthony, Chicas, Agustin, Li, Wencheng, Polotskaia, Alla, Bissell, Mina J., Osborne, Timothy F., Tian, Bin, Lowe, Scott W., Silva, Jose M., Børresen-Dale, Anne-Lise, Levine, Arnold J., Bargonetti, Jill, Prives, Carol

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p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells von Iannello, Alexandre, Thompson, Thornton W, Ardolino, Michele, Lowe, Scott W, Raulet, David H

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Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks von Schneider, William M., Luna, Joseph M., Hoffmann, H.-Heinrich, Sánchez-Rivera, Francisco J., Leal, Andrew A., Ashbrook, Alison W., Le Pen, Jérémie, Ricardo-Lax, Inna, Michailidis, Eleftherios, Peace, Avery, Stenzel, Ansgar F., Lowe, Scott W., MacDonald, Margaret R., Rice, Charles M., Poirier, John T.

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Non-Cell-Autonomous Tumor Suppression by p53 von Lujambio, Amaia, Akkari, Leila, Simon, Janelle, Grace, Danielle, Tschaharganeh, Darjus F., Bolden, Jessica E., Zhao, Zhen, Thapar, Vishal, Joyce, Johanna A., Krizhanovsky, Valery, Lowe, Scott W.

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Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening von Sawey, Eric T., Chanrion, Maia, Cai, Chunlin, Wu, Guanming, Zhang, Jianping, Zender, Lars, Zhao, Alice, Busuttil, Ronald W., Yee, Herman, Stein, Lincoln, French, Dorothy M., Finn, Richard S., Lowe, Scott W., Powers, Scott

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A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference von Premsrirut, Prem K., Dow, Lukas E., Kim, Sang Yong, Camiolo, Matthew, Malone, Colin D., Miething, Cornelius, Scuoppo, Claudio, Zuber, Johannes, Dickins, Ross A., Kogan, Scott C., Shroyer, Kenneth R., Sordella, Raffaella, Hannon, Gregory J., Lowe, Scott W.

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Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53 von Bywater, Megan J., Poortinga, Gretchen, Sanij, Elaine, Hein, Nadine, Peck, Abigail, Cullinane, Carleen, Wall, Meaghan, Cluse, Leonie, Drygin, Denis, Anderes, Kenna, Huser, Nanni, Proffitt, Chris, Bliesath, Joshua, Haddach, Mustapha, Schwaebe, Michael K., Ryckman, David M., Rice, William G., Schmitt, Clemens, Lowe, Scott W., Johnstone, Ricky W., Pearson, Richard B., McArthur, Grant A., Hannan, Ross D.

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NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination von Ruscetti, Marcus, Leibold, Josef, Bott, Matthew J, Fennell, Myles, Kulick, Amanda, Salgado, Nelson R, Chen, Chi-Chao, Ho, Yu-Jui, Sanchez-Rivera, Francisco J, Feucht, Judith, Baslan, Timour, Tian, Sha, Chen, Hsuan-An, Romesser, Paul B, Poirier, John T, Rudin, Charles M, de Stanchina, Elisa, Manchado, Eusebio, Sherr, Charles J, Lowe, Scott W

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A combinatorial strategy for treating KRAS-mutant lung cancer von Manchado, Eusebio, Weissmueller, Susann, Morris, John P., Chen, Chi-Chao, Wullenkord, Ramona, Lujambio, Amaia, de Stanchina, Elisa, Poirier, John T., Gainor, Justin F., Corcoran, Ryan B., Engelman, Jeffrey A., Rudin, Charles M., Rosen, Neal, Lowe, Scott W.

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Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay von Fellmann, Christof, Zuber, Johannes, McJunkin, Katherine, Chang, Kenneth, Malone, Colin D., Dickins, Ross A., Xu, Qikai, Hengartner, Michael O., Elledge, Stephen J., Hannon, Gregory J., Lowe, Scott W.

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miR-221 overexpression contributes to liver tumorigenesis von Pineau, Pascal, Volinia, Stefano, McJunkin, Katherine, Marchio, Agnès, Battiston, Carlo, Terris, Benoît, Mazzaferro, Vincenzo, Lowe, Scott W, Croce, Carlo M, Dejean, Anne

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Senescence of Activated Stellate Cells Limits Liver Fibrosis von Krizhanovsky, Valery, Yon, Monica, Dickins, Ross A., Hearn, Stephen, Simon, Janelle, Miething, Cornelius, Yee, Herman, Zender, Lars, Lowe, Scott W.

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A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response von Hoshii, Takayuki, Cifani, Paolo, Feng, Zhaohui, Huang, Chun-Hao, Koche, Richard, Chen, Chun-Wei, Delaney, Christopher D., Lowe, Scott W., Kentsis, Alex, Armstrong, Scott A.

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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function von Sakamaki, Jun-ichi, Wilkinson, Simon, Hahn, Marcel, Tasdemir, Nilgun, O’Prey, Jim, Clark, William, Hedley, Ann, Nixon, Colin, Long, Jaclyn S., New, Maria, Van Acker, Tim, Tooze, Sharon A., Lowe, Scott W., Dikic, Ivan, Ryan, Kevin M.

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Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors von Hoffmann, H.-Heinrich, Sánchez-Rivera, Francisco J., Schneider, William M., Luna, Joseph M., Soto-Feliciano, Yadira M., Ashbrook, Alison W., Le Pen, Jérémie, Leal, Andrew A., Ricardo-Lax, Inna, Michailidis, Eleftherios, Hao, Yuan, Stenzel, Ansgar F., Peace, Avery, Zuber, Johannes, Allis, C. David, Lowe, Scott W., MacDonald, Margaret R., Poirier, John T., Rice, Charles M.

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Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling von Weissmueller, Susann, Manchado, Eusebio, Saborowski, Michael, Morris, 4th, John P, Wagenblast, Elvin, Davis, Carrie A, Moon, Sung-Hwan, Pfister, Neil T, Tschaharganeh, Darjus F, Kitzing, Thomas, Aust, Daniela, Markert, Elke K, Wu, Jianmin, Grimmond, Sean M, Pilarsky, Christian, Prives, Carol, Biankin, Andrew V, Lowe, Scott W

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Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer von O'Rourke, Kevin P, Loizou, Evangelia, Livshits, Geulah, Schatoff, Emma M, Baslan, Timour, Manchado, Eusebio, Simon, Janelle, Romesser, Paul B, Leach, Benjamin, Han, Teng, Pauli, Chantal, Beltran, Himisha, Rubin, Mark A, Dow, Lukas E, Lowe, Scott W

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High resolution copy number inference in cancer using short-molecule nanopore sequencing von Baslan, Timour, Kovaka, Sam, Sedlazeck, Fritz J, Zhang, Yanming, Wappel, Robert, Tian, Sha, Lowe, Scott W, Goodwin, Sara, Schatz, Michael C

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Life in the Fast Lane: Mammalian Disease Models in the Genomics Era von Dow, Lukas E., Lowe, Scott W.

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