A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-Cell Stemness Shows Enhanced CAR T-Cell Efficacy in Preclinical and Early Clinical Development von Dickinson, Michael J, Barba, Pere, Jager, Ulrich, Shah, Nirav N, Blaise, Didier, Briones, Javier, Shune, Leyla, Boissel, Nicolas, Bondanza, Attilio, Mariconti, Luisa, Marchal, Anne-Laure, Quinn, David S, Yang, Jennifer, Price, Andrew, Sohoni, Akash, Treanor, Louise M, Orlando, Elena J, Mataraza, Jennifer, Davis, Jaclyn, Lu, Darlene, Zhu, Xu, Engels, Boris, Moutouh-de Parseval, Laure, Brogdon, Jennifer L, Moschetta, Michele, Flinn, Ian W

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Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential von Treanor, Louise M, Zhou, Sheng, Janke, Laura, Churchman, Michelle L, Ma, Zhijun, Lu, Taihe, Chen, Shann-Ching, Mullighan, Charles G, Sorrentino, Brian P

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Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies von Treanor, Louise M., Volanakis, Emmanuel J., Zhou, Sheng, Lu, Taihe, Sherr, Charles J., Sorrentino, Brian P.

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Identification and Development of PHE885: A Novel and Highly Potent Fully Human Anti-BCMA CAR-T Manufactured with a Novel T-Charge TM Platform for the Treatment of Multiple Myeloma von Bu, Dexiu, Bennett, Paul, Barton, Nathaniel, Bradshaw, Laura, Pinon-Ortiz, Maria, Li, Xiangen, Vaidya, Poonam, Zhu, Xu, Mansfield, Keith, Granda, Brian, Guimaraes, Carla P, Treanor, Louise M, Brogdon, Jennifer L

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Preservation of T-Cell Stemness with a Novel Expansionless CAR-T Manufacturing Process, Which Reduces Manufacturing Time to Less Than Two Days, Drives Enhanced CAR-T Cell Efficacy von Engels, Boris, Zhu, Xu, Yang, Jennifer, Price, Andrew, Sohoni, Akash, Stein, Andrew M, Parent, Lana, Greene, Michael, Niederst, Matthew, Whalen, Jeanne, Orlando, Elena J, Treanor, Louise M, Brogdon, Jennifer L

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445. A Delectable Lentiviral Vector System for Testing Oncogene Addiction in Hematological Malignancies von Maciaszek, Jamie L., Treanor, Louise M., Sorrentino, Brian P.

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Phase I Study of PHE885, a Fully Human BCMA-Directed CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Manufactured in <2 Days Using the T-Charge TM Platform von Sperling, Adam S., Nikiforow, Sarah, Nadeem, Omar, Mo, Clifton C, Laubach, Jacob P., Anderson, Kenneth C., Alonso, Alejandro, Ikegawa, Shuntaro, Prabhala, Rao, Hernandez Rodriguez, Diego, Daley, Heather, Shaw, Kit L., Arihara, Yohei, Ansari, Soudeh, Quinn, David S, Pearson, David, Hack, Anniesha, Treanor, Louise M, Bu, Dexiu, Mataraza, Jennifer, Rispoli, Lawrence, Credi, Marc, Ritz, Jerome, De Vita, Serena, Munshi, Nikhil C.

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260 Investigating cancer cell autonomous CAR T cell therapy resistance in DLBCL in vitro von Lueoend, Fabiana, Song, Youngchul, Nguyen, Beverly, Li, Xiaoyan, Raue, Andreas, Brogdon, Jennifer, Dranoff, Glenn, Niederst, Matthew, Treanor, Louise

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N-Myc Is Overexpressed In Both Murine and Human Early T-Cell Precursor Leukemia and Is Sufficient To Initiate this Leukemia In Multipotent Primitive Arf-/- thymocytes von Treanor, Louise M., Zhou, Sheng, Fukuda, Yu, Satish, Nandakumar, Finkelstein, David, Schuetz, John D., Mullighan, Charles G., Sorrentino, Brian P.

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Loss of p19Arf Increases the Self-Renewal Capacity of Immature Thymocytes That Over-Express LMO2 von Treanor, Louise M., Zhou, Sheng, Lu, Taihe, Sorrentino, Brian P.

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IL7r receptor mutants initiate leukemia from multipotent primitive thymocytes in a novel mouse model of ETP leukemia von Treanor, Louise, Zhou, Sheng, Janke, Laura, Chen, Shann-Ching, Mullighan, Charles, Sorrentino, Brian

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Lmo2 Overexpression and Arf Loss Induce Myeloid Differentiation in Primitive Thymocytes von Treanor, Louise M., Zhou, Sheng, Lu, Taihe, Mullighan, Charles G, Sorrentino, Brian P.

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Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells von TREANOR, Louise, BELLAMY, Christopher, HARRISON, David J, PROST, Sandrine

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Functional interactions between Lmo2, the Arf tumor suppressor, and Notch in murine T-cell malignancies von TREANOR, Louise M, VOLANAKIS, Emmanuel J, SHENG ZHOU, TAIHE LU, SHERR, Charles J, SORRENTINO, Brian P

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Expression of the Arf tumor suppressor gene is controlled by Tgfβ2 during development von Freeman-Anderson, Natalie E., Zheng, Yanbin, McCalla-Martin, Amy C., Treanor, Louise M., Zhao, Yi D., Garfin, Phillip M., He, Tong-Chuan, Mary, Michelle N., Thornton, J. Derek, Anderson, Colleen, Gibbons, Melissa, Saab, Raya, Baumer, Shannon H., Cunningham, John M., Skapek, Stephen X.

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Additive effect of p53, p21 and Rb deletion in triple knockout primary hepatocytes von Sheahan, Sharon, Bellamy, Christopher OC, Treanor, Louise, Harrison, David J, Prost, Sandrine

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Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development von Freeman-Anderson, Natalie E, Zheng, Yanbin, McCalla-Martin, Amy C, Treanor, Louise M, Zhao, Yi D, Garfin, Phillip M, He, Tong-Chuan, Mary, Michelle N, Thornton, J Derek, Anderson, Colleen, Gibbons, Melissa, Saab, Raya, Baumer, Shannon H, Cunningham, John M, Skapek, Stephen X

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A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-cell Stemness Shows Enhanced CAR T-cell Efficacy in Preclinical and Early Clinical Development von Dickinson, Michael, Barba, Pere, Jäger, Ulrich, Shah, Nirav N, Blaise, Didier, Briones Meijide, Javier, Shune, Leyla, Boissel, Nicolas, Bondanza, Attilio, Mariconti, Luisa, Marchal, Anne-Laure, Quinn, David S, Yang, Jennifer, Price, Andrew, Sohoni, Akash, Treanor, Louise M, Orlando, Elena J, Mataraza, Jennifer, Davis, Jaclyn, Lu, Darlene, Zhu, Xu, Engels, Boris, Moutouh-de Parseval, Laure, Brogdon, Jennifer L, Moschetta, Michele, Flinn, Ian W, Universitat Autònoma de Barcelona

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METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS von Jayashankar, Shyamali, Price, Andrew Patrick, Granda, Brian Walter, Bardroff, Michael, Cebe, Regis, Treanor, Louise Mary, Yang, Jennifer, Miller, Sandra, Rayo, Amy, Koshy, Sandeep Tharian, Skegro, Darko

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METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR?EXPRESSING CELLS von TREANOR, Louise Mary, KOSHY, Sandeep Tharian, RAYO, Amy, MILLER, Sandra, CEBE, Regis, PRICE, Andrew Patrick, JAYASHANKAR, Shyamali, SKEGRO, Darko, YANG, Jennifer, GRANDA, Brian Walter, BARDROFF, Michael

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