ABBV-399, a c-Met Antibody-Drug Conjugate that Targets Both MET -Amplified and c-Met-Overexpressing Tumors, Irrespective of MET Pathway Dependence von Wang, Jieyi, Anderson, Mark G, Oleksijew, Anatol, Vaidya, Kedar S, Boghaert, Erwin R, Tucker, Lora, Zhang, Qian, Han, Edward K, Palma, Joann P, Naumovski, Louie, Reilly, Edward B

Volltext

The Novel Expanded Porphyrin, Motexafin Gadolinium, Combined with [90Y]Ibritumomab Tiuxetan for Relapsed/Refractory Non-Hodgkin's Lymphoma: Preclinical Findings and Results of a Ph... von EVENS, Andrew M, SPIES, William G, NAUMOVSKI, Louie, ROSEN, Steven T, WINTER, Jane N, MILLER, Richard A, GORDON, Leo I, HELENOWSKI, Irene B, PATTON, David, SPIES, Stewart, JOVANOVIC, Borko D, MIYATA, Sarah, HAMILTON, Elizabeth, VARIAKOJIS, Daina, JUN CHEN

Volltext

A first-in-human, phase 1, dose-escalation study of ABBV-176, an antibody-drug conjugate targeting the prolactin receptor, in patients with advanced solid tumors von Lemech, Charlotte, Woodward, Natasha, Chan, Nancy, Mortimer, Joanne, Naumovski, Louie, Nuthalapati, Silpa, Tong, Bo, Jiang, Fang, Ansell, Peter, Ratajczak, Christine K., Sachdev, Jasgit

Volltext

ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models von Li, Yingchun, Hickson, Jonathan A, Ambrosi, Dominic J, Haasch, Deanna L, Foster-Duke, Kelly D, Eaton, Lucia J, DiGiammarino, Enrico L, Panchal, Sanjay C, Jiang, Fang, Mudd, Sarah R, Zhang, Catherine, Akella, Surekha S, Gao, Wenqing, Ralston, Sherry L, Naumovski, Louie, Gu, Jijie, Morgan-Lappe, Susan E

Volltext

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53 von Samuels-Lev, Yardena, O'Connor, Daniel J., Bergamaschi, Daniele, Trigiante, Giuseppe, Hsieh, Jung-Kuang, Zhong, Shan, Campargue, Isabelle, Naumovski, Louie, Crook, Tim, Lu, Xin

Volltext

Oncology early development technology to facilitate early analysis of safety and efficacy data von Vaca, Mireya, Naumovski, Louie, Soh, Chang-Heok, Leal, Jailene

Volltext

Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites von HUA QIAN, TING WANG, NAUMOVSKI, Louie, LOPEZ, Charles D, BRACHMANN, Rainer K

Volltext

Vascular cell apoptosis : Cell type-specific modulation by transforming growth Factor-β1 in endothelial cells versus smooth muscle cells von POLLMAN, M. J, NAUMOVSKI, L, GIBBONS, G. H

Volltext

Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds von Kampa, Kerstin M, Acoba, Jared D, Chen, Dexi, Gay, Joel, Lee, Hunjoo, Beemer, Kelly, Padiernos, Emerson, Boonmark, Nataya, Zhu, Zhiyi, Fan, Alice C, Bailey, Alexis S, Fleming, William H, Corless, Christopher, Felsher, Dean W, Naumovski, Louie, Lopez, Charles D

Volltext

Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines von LECANE, Philip S, KARAMAN, Mazen W, SIRISAWAD, Mint, NAUMOVSKI, Louie, MILLER, Richard A, HACIA, Joseph G, MAGDA, Darren

Volltext

Motexafin gadolinium modulates levels of phosphorylated Akt and synergizes with inhibitors of Akt phosphorylation von Ramos, Jason, Sirisawad, Mint, Miller, Richard, Naumovski, Louie

Volltext

Endothelial cell apoptosis in capillary network remodeling von Pollman, Matthew J., Naumovski, Louie, Gibbons, Gary H.

Volltext

Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression von Wang, Zhong, Lecane, Philip S, Thiemann, Patricia, Fan, Qing, Cortez, Cecilia, Ma, Xuan, Tonev, Danielle, Miles, Dale, Naumovski, Louie, Miller, Richard A, Magda, Darren, Cho, Dong-Gyu, Sessler, Jonathan L, Pike, Brian L, Yeligar, Samantha M, Karaman, Mazen W, Hacia, Joseph G

Volltext

First-in-Human Phase I, Dose-Escalation and -Expansion Study of Telisotuzumab Vedotin, an Antibody-Drug Conjugate Targeting c-Met, in Patients With Advanced Solid Tumors von Strickler, John H, Weekes, Colin D, Nemunaitis, John, Ramanathan, Ramesh K, Heist, Rebecca S, Morgensztern, Daniel, Angevin, Eric, Bauer, Todd M, Yue, Huibin, Motwani, Monica, Parikh, Apurvasena, Reilly, Edward B, Afar, Daniel, Naumovski, Louie, Kelly, Karen

Volltext

Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells von Naumovski, L, Cleary, M L

Volltext

Sapphyrins induce apoptosis in hematopoietic tumor–derived cell lines and show in vivo antitumor activity von Naumovski, Louie, Ramos, Jason, Sirisawad, Mint, Chen, Jun, Thiemann, Patti, Lecane, Philip, Magda, Darren, Wang, Zhong, Cortez, Cecilia, Boswell, Garry, Gyu Cho, Dong, Sessler, Jonathan, Miller, Richard

Volltext

Tumor localization and antitumor efficacy of novel sapphyrin compounds von Naumovski, Louie, Sirisawad, Mint, Lecane, Philip, Chen, Jun, Ramos, Jason, Wang, Zhong, Cortez, Cecilia, Magda, Darren, Thiemann, Patti, Boswell, Garry, Miles, Dale, Cho, Dong Gyu, Sessler, Jonathan L, Miller, Richard

Volltext

Motexafin Gadolinium-Induced Cell Death Correlates with Heme oxygenase-1 Expression and Inhibition of P450 Reductase-Dependent Activities von Evans, John P., Xu, Fengyun, Sirisawad, Mint, Miller, Richard, Naumovski, Louie, de Montellano, Paul R. Ortiz

Volltext

Interferon-inducible Myc/STAT-interacting Protein Nmi Associates with IFP 35 into a High Molecular Mass Complex and Inhibits Proteasome-mediated Degradation of IFP 35 von Chen, Jun, Shpall, Rebecca L., Meyerdierks, Anke, Hagemeier, Mario, Böttger, Erik C., Naumovski, Louie

Volltext

First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors von Demetri, George D, Luke, Jason J, Hollebecque, Antoine, Powderly, 2nd, John D, Spira, Alexander I, Subbiah, Vivek, Naumovski, Louie, Chen, Chris, Fang, Hua, Lai, Dominic W, Yue, Huibin, Polepally, Akshanth R, Purcell, James W, Robinson, Randy, Sharma, Padmanee, Allison, James P, Tolcher, Anthony, Villalobos, Victor M

Volltext