From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) von Cheng, Yuan, Judd, Ted C, Bartberger, Michael D, Brown, James, Chen, Kui, Fremeau, Robert T, Hickman, Dean, Hitchcock, Stephen A, Jordan, Brad, Li, Vivian, Lopez, Patricia, Louie, Steven W, Luo, Yi, Michelsen, Klaus, Nixey, Thomas, Powers, Timothy S, Rattan, Claire, Sickmier, E. Allen, St. Jean, David J, Wahl, Robert C, Wen, Paul H, Wood, Stephen

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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux von Rzasa, Robert M., Hu, Essa, Rumfelt, Shannon, Chen, Ning, Andrews, Kristin L., Chmait, Samer, Falsey, James R., Zhong, Wenge, Jones, Adrie D., Porter, Amy, Louie, Steven W., Zhao, Xiaoning, Treanor, James J.S., Allen, Jennifer R.

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Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide) von Subramanian, Raju, Zhu, Xiaochun, Kerr, Savannah J, Esmay, Joel D, Louie, Steven W, Edson, Katheryne Z, Walter, Sarah, Fitzsimmons, Michael, Wagner, Mylo, Soto, Marcus, Pham, Roger, Wilson, Sarah F, Skiles, Gary L

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Disubstituted 1‑Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch and Flow Technologies von Bryan, Marian C, Hein, Christopher D, Gao, Hua, Xia, Xiaoyang, Eastwood, Heather, Bruenner, Bernd A, Louie, Steven W, Doherty, Elizabeth M

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Development and characterization of LLC-PK1 cells containing Sprague–Dawley rat Abcb1a ( Mdr1a): Comparison of rat P-glycoprotein transport to human and mouse von Booth-Genthe, Catherine L., Louie, Steven W., Carlini, Edward J., Li, Bing, Leake, Brenda F., Eisenhandler, Roy, Hochman, Jerome H., Mei, Qin, Kim, Richard B., Rushmore, Thomas H., Yamazaki, Masayo

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Positive and negative regulation of Thy-1 expression on B lymphocytes by IL-4 von Louie, Steven W., Ramirez, Luis M., Harton, Jonathan A., Bishop, Gail A.

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Observations of nitryl chloride and modeling its source and effect on ozone in the planetary boundary layer of southern China von Wang, Tao, Tham, Yee Jun, Xue, Likun, Li, Qinyi, Zha, Qiaozhi, Wang, Zhe, Poon, Steven C. N., Dubé, William P., Blake, Donald R., Louie, Peter K. K., Luk, Connie W. Y., Tsui, Wilson, Brown, Steven S.

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Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients von Nissen, Steven E., Lincoff, A. Michael, Brennan, Danielle, Ray, Kausik K., Mason, Denise, Kastelein, John J.P., Thompson, Paul D., Libby, Peter, Cho, Leslie, Plutzky, Jorge, Bays, Harold E., Moriarty, Patrick M., Menon, Venu, Grobbee, Diederick E., Louie, Michael J., Chen, Chien-Feng, Li, Na, Bloedon, LeAnne, Robinson, Paula, Horner, Maggie, Sasiela, William J., McCluskey, Jackie, Davey, Deborah, Fajardo-Campos, Pedro, Petrovic, Predrag, Fedacko, Jan, Zmuda, Witold, Lukyanov, Yury, Nicholls, Stephen J.

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Controlling inelastic light scattering quantum pathways in graphene von Chen, Chi-Fan, Park, Cheol-Hwan, Boudouris, Bryan W., Horng, Jason, Geng, Baisong, Girit, Caglar, Zettl, Alex, Crommie, Michael F., Segalman, Rachel A., Louie, Steven G., Wang, Feng

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Genomic signatures of Lake Erie bacteria suggest interaction in the Microcystis phycosphere von Hoke, Alexa K., Reynoso, Guadalupe, Smith, Morgan R., Gardner, Malia, Lockwood, Dominique J., Gilbert, Naomi E., Wilhelm, Steven W., Becker, Isabella R., Brennan, Grant J., Crider, Katherine E., Farnan, Shannon R., Mendoza, Victoria, Poole, Alison C., Zimmerman, Zachary P., Utz, Lucy K., Wurch, Louie L., Steffen, Morgan M.

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Observing Atomic Collapse Resonances in Artificial Nuclei on Graphene von Wang, Yang, Wong, Dillon, Shytov, Andrey V., Brar, Victor W., Choi, Sangkook, Wu, Qiong, Tsai, Hsin-Zon, Regan, William, Zettl, Alex, Kawakami, Roland K., Louie, Steven G., Levitov, Leonid S., Crommie, Michael F.

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Virus-host relationships of marine single-celled eukaryotes resolved from metatranscriptomics von Moniruzzaman, Mohammad, Wurch, Louie L., Alexander, Harriet, Dyhrman, Sonya T., Gobler, Christopher J., Wilhelm, Steven W.

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Seasonal behavior of carbonyls and source characterization of formaldehyde (HCHO) in ambient air von Lui, K.H., Ho, Steven Sai Hang, Louie, Peter K.K., Chan, C.S., Lee, S.C., Hu, Di, Chan, P.W., Lee, Jeffrey Chi Wai, Ho, K.F.

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Gate-controlled ionization and screening of cobalt adatoms on a graphene surface von Brar, Victor W, Decker, Régis, Solowan, Hans-Michael, Wang, Yang, Maserati, Lorenzo, Chan, Kevin T, Lee, Hoonkyung, Girit, Ça lar O, Zettl, Alex, Louie, Steven G, Cohen, Marvin L, Crommie, Michael F

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Atmospheric Peroxides in a Polluted Subtropical Environment: Seasonal Variation, Sources and Sinks, and Importance of Heterogeneous Processes von Guo, Jia, Tilgner, Andreas, Yeung, Chungpong, Wang, Zhe, Louie, Peter K. K, Luk, Connie W. Y, Xu, Zheng, Yuan, Chao, Gao, Yuan, Poon, Steven, Herrmann, Hartmut, Lee, Shuncheng, Lam, Ka Se, Wang, Tao

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Widespread adenine N6-methylation of active genes in fungi von Mondo, Stephen J, Dannebaum, Richard O, Kuo, Rita C, Louie, Katherine B, Bewick, Adam J, LaButti, Kurt, Haridas, Sajeet, Kuo, Alan, Salamov, Asaf, Ahrendt, Steven R, Lau, Rebecca, Bowen, Benjamin P, Lipzen, Anna, Sullivan, William, Andreopoulos, Bill B, Clum, Alicia, Lindquist, Erika, Daum, Christopher, Northen, Trent R, Kunde-Ramamoorthy, Govindarajan, Schmitz, Robert J, Gryganskyi, Andrii, Culley, David, Magnuson, Jon, James, Timothy Y, O'Malley, Michelle A, Stajich, Jason E, Spatafora, Joseph W, Visel, Axel, Grigoriev, Igor V

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Al‐Gazali Skeletal Dysplasia Constitutes the Lethal End of ADAMTSL2‐Related Disorders von Batkovskyte, Dominyka, McKenzie, Fiona, Taylan, Fulya, Simsek‐Kiper, Pelin Ozlem, Nikkel, Sarah M, Ohashi, Hirofumi, Stevenson, Roger E, Ha, Thuong, Cavalcanti, Denise P, Miyahara, Hiroyuki, Skinner, Steven A, Aguirre, Miguel A, Akçören, Zühal, Utine, Gulen Eda, Chiu, Tillie, Shimizu, Kenji, Hammarsjö, Anna, Boduroglu, Koray, Moore, Hannah W, Louie, Raymond J, Arts, Peer, Merrihew, Allie N, Babic, Milena, Jackson, Matilda R, Papadogiannakis, Nikos, Lindstrand, Anna, Nordgren, Ann, Barnett, Christopher P, Scott, Hamish S, Chagin, Andrei S, Nishimura, Gen, Grigelioniene, Giedre

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The TESS Objects of Interest Catalog from the TESS Prime Mission von Guerrero, Natalia M., Seager, S., Huang, Chelsea X., Vanderburg, Andrew, Soto, Aylin Garcia, Mireles, Ismael, Hesse, Katharine, Fong, William, Glidden, Ana, Shporer, Avi, Latham, David W., Quinn, Samuel N., Burt, Jennifer, Dragomir, Diana, Crossfield, Ian, Vanderspek, Roland, Fausnaugh, Michael, Burke, Christopher J., Ricker, George, Daylan, Tansu, Essack, Zahra, Günther, Maximilian N., Osborn, Hugh P., Pepper, Joshua, Rowden, Pamela, Sha, Lizhou, Villanueva Jr, Steven, Yu, Liang, Ballard, Sarah, Batalha, Natalie M., Berardo, David, Chontos, Ashley, Dittmann, Jason A., Esquerdo, Gilbert A., Mikal-Evans, Thomas, Jayaraman, Rahul, Krishnamurthy, Akshata, Louie, Dana R., Mehrle, Nicholas, Niraula, Prajwal, Rackham, Benjamin V., Rodriguez, Joseph E., Rowden, Stephen J. L., Sousa-Silva, Clara, Watanabe, David, Wong, Ian, Zivanovic, Goran, Christiansen, Jessie L., Ciardi, David R., Swain, Melanie A., Lund, Michael B., Mullally, Susan E., Fleming, Scott W., Rodriguez, David R., Boyd, Patricia T., Quintana, Elisa V., Barclay, Thomas, Rinehart, S. A., Schlieder, Joshua E., Clampin, Mark, Jenkins, Jon M., Twicken, Joseph D., Caldwell, Douglas A., Coughlin, Jeffrey L., Henze, Chris, Lissauer, Jack J., Morris, Robert L., Rose, Mark E., Smith, Jeffrey C., Tenenbaum, Peter, Ting, Eric B., Wohler, Bill, Bakos, G. Á., Bean, Jacob L., Berta-Thompson, Zachory K., Bieryla, Allyson, Bouma, Luke G., Buchhave, Lars A., Butler, Nathaniel, Doty, John P., Ge, Jian, Holman, Matthew J., Howard, Andrew W., Kaltenegger, Lisa, Kane, Stephen R., Kjeldsen, Hans, Kreidberg, Laura, Lin, Douglas N. C., Minsky, Charlotte, Narita, Norio, Paegert, Martin, Pál, András, Palle, Enric, Sasselov, Dimitar D., Spencer, Alton, Sozzetti, Alessandro, Stassun, Keivan G., Torres, Guillermo, Udry, Stephane, Winn, Joshua N.

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Adipocytes Impair Leukemia Treatment in Mice von BEHAN, James W, YUN, Jason P, MITTELMAN, Steven D, PROEKTOR, Marina P, EHSANIPOUR, Ehsan A, ARUTYUNYAN, Anna, MOSES, Ara S, AVRAMIS, Vassilios I, LOUIS, Stan G, BUTTURINI, Anna, HEISTERKAMP, Nora

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Functional correlation of genome‐wide DNA methylation profiles in genetic neurodevelopmental disorders von Levy, Michael A., Relator, Raissa, McConkey, Haley, Pranckeviciene, Erinija, Kerkhof, Jennifer, Barat‐Houari, Mouna, Bargiacchi, Sara, Biamino, Elisa, Palomares Bralo, María, Cappuccio, Gerarda, Ciolfi, Andrea, Clarke, Angus, DuPont, Barbara R., Elting, Mariet W., Faivre, Laurence, Fee, Timothy, Ferilli, Marco, Fletcher, Robin S., Cherick, Florian, Foroutan, Aidin, Friez, Michael J., Gervasini, Cristina, Haghshenas, Sadegheh, Hilton, Benjamin A., Jenkins, Zandra, Kaur, Simranpreet, Lewis, Suzanne, Louie, Raymond J., Maitz, Silvia, Milani, Donatella, Morgan, Angela T., Oegema, Renske, Østergaard, Elsebet, Pallares, Nathalie R., Piccione, Maria, Plomp, Astrid S., Poulton, Cathryn, Reilly, Jack, Rius, Rocio, Robertson, Stephen, Rooney, Kathleen, Rousseau, Justine, Santen, Gijs W. E., Santos‐Simarro, Fernando, Schijns, Josephine, Squeo, Gabriella M., John, Miya St, Thauvin‐Robinet, Christel, Traficante, Giovanna, Sluijs, Pleuntje J., Vergano, Samantha A., Vos, Niels, Walden, Kellie K., Azmanov, Dimitar, Balci, Tugce B., Banka, Siddharth, Gecz, Jozef, Henneman, Peter, Lee, Jennifer A., Mannens, Marcel M. A. M., Roscioli, Tony, Siu, Victoria, Amor, David J., Baynam, Gareth, Bend, Eric G., Boycott, Kym, Brunetti‐Pierri, Nicola, Campeau, Philippe M., Campion, Dominique, Christodoulou, John, Dyment, David, Esber, Natacha, Fahrner, Jill A., Fleming, Mark D., Genevieve, David, Heron, Delphine, Husson, Thomas, Kernohan, Kristin D., McNeill, Alisdair, Menke, Leonie A., Merla, Giuseppe, Prontera, Paolo, Rockman‐Greenberg, Cheryl, Schwartz, Charles, Skinner, Steven A., Stevenson, Roger E., Vincent, Marie, Vitobello, Antonio, Tartaglia, Marco, Alders, Marielle, Tedder, Matthew L., Sadikovic, Bekim

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