Phosphorylation of NLRC4 is critical for inflammasome activation von Qu, Yan, Misaghi, Shahram, Izrael-Tomasevic, Anita, Newton, Kim, Gilmour, Laurie L., Lamkanfi, Mohamed, Louie, Salina, Kayagaki, Nobuhiko, Liu, Jinfeng, Kömüves, László, Cupp, James E., Arnott, David, Monack, Denise, Dixit, Vishva M.

Volltext

Endothelial intercellular cell adhesion molecule 1 contributes to cell aggregate formation in CHO cells cultured in serum‐free media von Louie, Salina, Heidersbach, Amy, Blanco, Noelia, Haley, Benjamin, Rose, Christopher M., Liu, Peter S., Yim, Mandy, Tang, Danming, Lam, Cynthia, Sandoval, Wendy N., Shaw, David, Snedecor, Brad, Misaghi, Shahram

Volltext

Non-canonical inflammasome activation targets caspase-11 von Kayagaki, Nobuhiko, Warming, Søren, Lamkanfi, Mohamed, Walle, Lieselotte Vande, Louie, Salina, Dong, Jennifer, Newton, Kim, Qu, Yan, Liu, Jinfeng, Heldens, Sherry, Zhang, Juan, Lee, Wyne P., Roose-Girma, Merone, Dixit, Vishva M.

Volltext

Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation von Qu, Yan, Misaghi, Shahram, Newton, Kim, Gilmour, Laurie L, Louie, Salina, Cupp, James E, Dubyak, George R, Hackos, David, Dixit, Vishva M

Volltext

UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD von Tang, Danming, Sandoval, Wendy, Lam, Cynthia, Haley, Benjamin, Liu, Peter, Xue, Di, Roy, Deepankar, Patapoff, Tom, Louie, Salina, Snedecor, Brad, Misaghi, Shahram

Volltext

Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media von Louie, Salina, Lakkyreddy, Jayanthi, Castellano, Brian M., Haley, Benjamin, Nguyen Dang, Anh, Lam, Cynthia, Tang, Danming, Lang, Steven, Snedecor, Brad, Misaghi, Shahram

Volltext

FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality von Louie, Salina, Haley, Benjamin, Marshall, Brett, Heidersbach, Amy, Yim, Mandy, Brozynski, Martina, Tang, Danming, Lam, Cynthia, Petryniak, Bronislawa, Shaw, David, Shim, Jeongsup, Miller, Aaron, Lowe, John B., Snedecor, Brad, Misaghi, Shahram

Volltext

Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally‐derived or not von Zhou, Yizhou, Shaw, David, Lam, Cynthia, Tsukuda, Joni, Yim, Mandy, Tang, Danming, Louie, Salina, Laird, Michael W., Snedecor, Brad, Misaghi, Shahram

Volltext

Utilizing a regulated targeted integration cell line development approach to systematically investigate what makes an antibody difficult to express von Tadauchi, Tomofumi, Lam, Cynthia, Liu, Laura, Zhou, Yizhou, Tang, Danming, Louie, Salina, Snedecor, Brad, Misaghi, Shahram

Volltext

Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt‐ and actin‐resistant variant of human deoxyribonuclease I in CHO cells von Lam, Cynthia, Santell, Lydia, Wilson, Blair, Yim, Mandy, Louie, Salina, Tang, Danming, Shaw, David, Chan, Pamela, Lazarus, Robert A., Snedecor, Brad, Misaghi, Shahram

Volltext

Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost‐effective method for expression of complex molecules von Dong, Emily, Lam, Cynthia, Tang, Danming, Louie, Salina, Yim, Mandy, Williams, Ambrose J., Sawyer, William, Yip, Shirley, Carver, Joseph, AlBarakat, Ali, Tsukuda, Joni, Snedecor, Brad, Misaghi, Shahram

Volltext

Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System von Tang, Danming, Lam, Cynthia, Louie, Salina, Hoi, Kam Hon, Shaw, David, Yim, Mandy, Snedecor, Brad, Misaghi, Shahram

Volltext

Slashing the timelines: Opting to generate high-titer clonal lines faster via viability-based single cell sorting von Misaghi, Shahram, Shaw, David, Louie, Salina, Nava, Adrian, Simmons, Laura, Snedecor, Brad, Poon, Chungkee, Paw, Jonathan S., Gilmour-Appling, Laurie, Cupp, James E.

Volltext

Taming hyperactive h DN ase I: Stable inducible expression of a hyperactive salt‐ and actin‐resistant variant of human deoxyribonuclease I in CHO cells von Lam, Cynthia, Santell, Lydia, Wilson, Blair, Yim, Mandy, Louie, Salina, Tang, Danming, Shaw, David, Chan, Pamela, Lazarus, Robert A., Snedecor, Brad, Misaghi, Shahram

Volltext

Slashing the timelines: Opting to generate high-titer clonal lines faster via viability-based single cell sorting: Biotechnol. Prog von Misaghi, Shahram, Shaw, David, Louie, Salina, Nava, Adrian, Simmons, Laura, Snedecor, Brad, Poon, Chungkee, Paw, Jonathan S., Gilmour-Appling, Laurie, Cupp, James E.

Volltext

Epilogue

Volltext bestellen

Un assassinat aux Champs Elysées

Volltext bestellen