Rethinking ovarian cancer: recommendations for improving outcomes von Bowtell, David D, Vaughan, Sebastian, Coward, Jermaine I, Bast, Robert C, Berchuck, Andy, Berek, Jonathan S, Brenton, James D, Coukos, George, Crum, Christopher C, Drapkin, Ronny, Etemadmoghadam, Dariush, Friedlander, Michael, Gabra, Hani, Kaye, Stan B, Lord, Chris J, Lengyel, Ernst, Levine, Douglas A, McNeish, Iain A, Menon, Usha, Mills, Gordon B, Nephew, Kenneth P, Oza, Amit M, Sood, Anil K, Stronach, Euan A, Walczak, Henning, Balkwill, Frances R

Volltext

Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines von Ha, Kevin C H, Lalonde, Emilie, Li, Lili, Cavallone, Luca, Natrajan, Rachael, Lambros, Maryou B, Mitsopoulos, Costas, Hakas, Jarle, Kozarewa, Iwanka, Fenwick, Kerry, Lord, Chris J, Ashworth, Alan, Vincent-Salomon, Anne, Basik, Mark, Reis-Filho, Jorge S, Majewski, Jacek, Foulkes, William D

Volltext

Hypertension treatment and control rates Chart review in an academic family medicine clinic von Houlihan, Sara J, Simpson, Scot H, Cave, Andrew J, Flook, Nigel W, Hurlburt, Mary E, Lord, Chris J, Smith, Linda L, Sternberg, Harvey H

Volltext

Abstract 2426: Exacerbation of oxidative DNA damage as a synthetic lethal approach in mismatch repair deficient tumors von Fontebasso, Yari, Hewish, Madeleine, Lord, Chris J., Ashworth, Alan

Volltext

Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response von O'Connor, Mark J., Cruz, Cristina, Castroviejo-Bermejo, Marta, Polanska, Urszula M., Jones, Gemma N., Wang, Anderson, Lai, Zhongwu, Forment, Josep, Bulusu, Krishna, Llop-Guevara, Alba, Dougherty, Brian, Saura, Cristina, Brough, Rachel, Lord, Chris J., Bruna, Alejandra, Caldas, Carlos, Fawell, Stephen, Barrett, J Carl, Critchlow, Susan E., Balmaña, Judith, Cadogan, Elaine, Serra, Violeta

Volltext

Abstract 2479: A functionally null RAD51D missense mutation is strongly associated with ovarian carcinoma von Rivera, Barbara, Iorio, Massimo R. Di, Frankum, Jessica, Nadaf, Javad, Fahiminiya, Somayyeh, Arcand, Suzanna L., Burk, David, Grapton, Damien, Tomiak, Eva, Hastings, Valerie, Hamel, Nancy, Wagener, Rabea, Aleynikova, Olga, Giroux, Sylvie, Hamdan, Fadi F., Orthwein, Alexandre, Zogopoulos, George, Rousseau, Francois, Berghuis, Albert, Provencher, Diane M., Rouleau, Guy A., Michaud, Jacques L., Mes-Masson, Anne-Marie, Majewski, Jacek, Bens, Susanne, Siebert, Reiner, Narod, Steven, Akbari, Mohammad, Lord, Chris J., Tonin, Patricia N., Dionne-Laporte, Alexandre, Foulkes, William D.

Volltext

Abstract 350: High-throughput drug screens identify novel synthetic lethal interactions with MLH1-deficient cancers von Hewish, Madeleine, Lord, Chris J., Martin, Sarah A., Cunningham, David, Ashworth, Alan

Volltext

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A von Williamson, Chris T., Miller, Rowan, Pemberton, Helen N., Jones, Samuel E., Campbell, James, Konde, Asha, Badham, Nicholas, Rafiq, Rumana, Brough, Rachel, Gulati, Aditi, Ryan, Colm J., Francis, Jeff, Vermulen, Peter B., Reynolds, Andrew R., Reaper, Philip M., Pollard, John R., Ashworth, Alan, Lord, Christopher J.

Volltext

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance von Zatreanu, Diana, Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert A., Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M., Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Bot, Chris, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Krajewski, Wojciech, MacDonald, Ellen, McCarron, Hollie, Pang, Leon, Pedder, Chris, Rigoreau, Laurent, Swarbrick, Martin, Wheatley, Ed, Willis, Simon, Wong, Ai Ching, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Stephen J., Smith, Graeme C. M., Lord, Christopher J.

Volltext

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines von Campbell, James, Ryan, Colm J., Brough, Rachel, Bajrami, Ilirjana, Pemberton, Helen N., Chong, Irene Y., Costa-Cabral, Sara, Frankum, Jessica, Gulati, Aditi, Holme, Harriet, Miller, Rowan, Postel-Vinay, Sophie, Rafiq, Rumana, Wei, Wenbin, Williamson, Chris T., Quigley, David A., Tym, Joe, Al-Lazikani, Bissan, Fenton, Timothy, Natrajan, Rachael, Strauss, Sandra J., Ashworth, Alan, Lord, Christopher J.

Volltext

The BRIDGE HadCM3 family of climate models: HadCM3@Bristol v1.0 von Valdes, Paul J., Armstrong, Edward, Badger, Marcus P. S., Bradshaw, Catherine D., Bragg, Fran, Crucifix, Michel, Davies-Barnard, Taraka, Day, Jonathan J., Farnsworth, Alex, Gordon, Chris, Hopcroft, Peter O., Kennedy, Alan T., Lord, Natalie S., Lunt, Dan J., Marzocchi, Alice, Parry, Louise M., Pope, Vicky, Roberts, William H. G., Stone, Emma J., Tourte, Gregory J. L., Williams, Jonny H. T.

Volltext

Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors von Yap, Timothy A, O'Carrigan, Brent, Penney, Marina S, Lim, Joline S, Brown, Jessica S, de Miguel Luken, Maria J, Tunariu, Nina, Perez-Lopez, Raquel, Rodrigues, Daniel Nava, Riisnaes, Ruth, Figueiredo, Ines, Carreira, Suzanne, Hare, Brian, McDermott, Katherine, Khalique, Saira, Williamson, Chris T, Natrajan, Rachael, Pettitt, Stephen J, Lord, Christopher J, Banerji, Udai, Pollard, John, Lopez, Juanita, de Bono, Johann S

Volltext

Modeling Therapy Resistance in BRCA1/2 -Mutant Cancers von Dréan, Amy, Williamson, Chris T, Brough, Rachel, Brandsma, Inger, Menon, Malini, Konde, Asha, Garcia-Murillas, Isaac, Pemberton, Helen N, Frankum, Jessica, Rafiq, Rumana, Badham, Nicholas, Campbell, James, Gulati, Aditi, Turner, Nicholas C, Pettitt, Stephen J, Ashworth, Alan, Lord, Christopher J

Volltext

Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice von Than, Martin P., MBBS, Pickering, John W., PhD, Aldous, Sally J., MBChB, PhD, Cullen, Louise, MBBS, PhD, Frampton, Christopher M.A., PhD, Peacock, W. Frank, MD, Jaffe, Allan S., MD, Goodacre, Steve W., PhD, Richards, A. Mark, MD, PhD, Ardagh, Michael W., PhD, Deely, Joanne M., PhD, Florkowski, Chris M., MBBS, MD, George, Peter, MBBS, Hamilton, Gregory J., PhD, Jardine, David L., MBChB, DCH, Troughton, Richard W., MBChB, PhD, van Wyk, Pieter, MBChB, Young, Joanna M., PhD, Bannister, Laura, MBBS, Lord, Sally J., MBBS

Volltext

Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study von Abubakar, Ibrahim, Drobniewski, Francis, Southern, Jo, Sitch, Alice J, Jackson, Charlotte, Lipman, Marc, Deeks, Jonathan J, Griffiths, Chris, Bothamley, Graham, Lynn, William, Burgess, Helen, Mann, Bobby, Imran, Ambreen, Sridhar, Saranya, Tsou, Chuen-Yan, Nikolayevskyy, Vladyslav, Rees-Roberts, Melanie, Whitworth, Hilary, Kon, Onn Min, Haldar, Pranab, Kunst, Heinke, Anderson, Sarah, Hayward, Andrew, Watson, John M, Milburn, Heather, Lalvani, Ajit, Adeboyeku, D, Bari, N, Barker, J, Booth, H, Chua, F, Creer, D, Darmalingam, M, Davidson, R N, Dedicoat, M, Dunleavy, A, Figueroa, J, Haseldean, M, Johnson, N, Losewicz, S, Lord, J, Moore-Gillon, J, Packe, G, Pareek, M, Tiberi, S, Pozniak, A, Sanderson, F

Volltext

Social Dancing and Incidence of Falls in Older Adults: A Cluster Randomised Controlled Trial von Merom, Dafna, Mathieu, Erin, Cerin, Ester, Morton, Rachael L, Simpson, Judy M, Rissel, Chris, Anstey, Kaarin J, Sherrington, Catherine, Lord, Stephen R, Cumming, Robert G

Volltext

ATR Is a Therapeutic Target in Synovial Sarcoma von Jones, Samuel E, Fleuren, Emmy D G, Frankum, Jessica, Konde, Asha, Williamson, Chris T, Krastev, Dragomir B, Pemberton, Helen N, Campbell, James, Gulati, Aditi, Elliott, Richard, Menon, Malini, Selfe, Joanna L, Brough, Rachel, Pettitt, Stephen J, Niedzwiedz, Wojciech, van der Graaf, Winette T A, Shipley, Janet, Ashworth, Alan, Lord, Christopher J

Volltext

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN von Bjerke, Lynn, Mackay, Alan, Nandhabalan, Meera, Burford, Anna, Jury, Alexa, Popov, Sergey, Bax, Dorine A, Carvalho, Diana, Taylor, Kathryn R, Vinci, Maria, Bajrami, Ilirjana, McGonnell, Imelda M, Lord, Christopher J, Reis, Rui M, Hargrave, Darren, Ashworth, Alan, Workman, Paul, Jones, Chris

Volltext

Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial von Becker, Clemens, Prof, Lord, Stephen R, Prof, Studenski, Stephanie A, MD, Warden, Stuart J, PhD, Fielding, Roger A, Prof, Recknor, Christopher P, MD, Hochberg, Marc C, Prof, Ferrari, Serge L, Prof, Blain, Hubert, Prof, Binder, Ellen F, Prof, Rolland, Yves, Prof, Poiraudeau, Serge, Prof, Benson, Charles T, MD, Myers, Stephen L, MD, Hu, Leijun, PhD, Ahmad, Qasim I, MD, Pacuch, Kelli R, Gomez, Elisa V, MS, Benichou, Olivier, Dr

Volltext

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells von Vinci, Mara, Burford, Anna, Molinari, Valeria, Kessler, Ketty, Popov, Sergey, Clarke, Matthew, Taylor, Kathryn R., Pemberton, Helen N., Lord, Christopher J., Gutteridge, Alice, Forshew, Tim, Carvalho, Diana, Marshall, Lynley V., Qin, Elizabeth Y., Ingram, Wendy J., Moore, Andrew S., Ng, Ho-Keung, Trabelsi, Saoussen, H’mida-Ben Brahim, Dorra, Entz-Werle, Natacha, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Sunol, Mariona, Mora, Jaume, de Torres, Carmen, Cruz, Ofelia, Carcaboso, Angel M., Monje, Michelle, Mackay, Alan, Jones, Chris

Volltext