Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS von Schneider, Rebekka K., Ademà, Vera, Heckl, Dirk, Järås, Marcus, Mallo, Mar, Lord, Allegra M., Chu, Lisa P., McConkey, Marie E., Kramann, Rafael, Mullally, Ann, Bejar, Rafael, Solé, Francesc, Ebert, Benjamin L.

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Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells von Carrelha, Joana, Meng, Yiran, Kettyle, Laura M., Luis, Tiago C., Norfo, Ruggiero, Alcolea, Verónica, Boukarabila, Hanane, Grasso, Francesca, Gambardella, Adriana, Grover, Amit, Högstrand, Kari, Lord, Allegra M., Sanjuan-Pla, Alejandra, Woll, Petter S., Nerlov, Claus, Jacobsen, Sten Eirik W.

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Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart von Cahill, Thomas J, Sun, Xin, Ravaud, Christophe, Villa Del Campo, Cristina, Klaourakis, Konstantinos, Lupu, Irina-Elena, Lord, Allegra M, Browne, Cathy, Jacobsen, Sten Eirik W, Greaves, David R, Jackson, David G, Cowley, Sally A, James, William, Choudhury, Robin P, Vieira, Joaquim Miguel, Riley, Paul R

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Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration von Goessling, Wolfram, North, Trista E., Loewer, Sabine, Lord, Allegra M., Lee, Sang, Stoick-Cooper, Cristi L., Weidinger, Gilbert, Puder, Mark, Daley, George Q., Moon, Randall T., Zon, Leonard I.

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Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation von Obeng, Esther A, Chappell, Ryan J, Seiler, Michael, Chen, Michelle C, Campagna, Dean R, Schmidt, Paul J, Schneider, Rebekka K, Lord, Allegra M, Wang, Lili, Gambe, Rutendo G, McConkey, Marie E, Ali, Abdullah M, Raza, Azra, Yu, Lihua, Buonamici, Silvia, Smith, Peter G, Mullally, Ann, Wu, Catherine J, Fleming, Mark D, Ebert, Benjamin L

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TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients von Bejar, Rafael, Lord, Allegra, Stevenson, Kristen, Bar-Natan, Michal, Pérez-Ladaga, Albert, Zaneveld, Jacques, Wang, Hui, Caughey, Bennett, Stojanov, Petar, Getz, Gad, Garcia-Manero, Guillermo, Kantarjian, Hagop, Chen, Rui, Stone, Richard M., Neuberg, Donna, Steensma, David P., Ebert, Benjamin L.

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Hematopoietic Stem Cell Development Is Dependent on Blood Flow von North, Trista E., Goessling, Wolfram, Peeters, Marian, Li, Pulin, Ceol, Craig, Lord, Allegra M., Weber, Gerhard J., Harris, James, Cutting, Claire C., Huang, Paul, Dzierzak, Elaine, Zon, Leonard I.

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Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells von Mullally, Ann, Lane, Steven W., Ball, Brian, Megerdichian, Christine, Okabe, Rachel, Al-Shahrour, Fatima, Paktinat, Mahnaz, Haydu, J. Erika, Housman, Elizabeth, Lord, Allegra M., Wernig, Gerlinde, Kharas, Michael G., Mercher, Thomas, Kutok, Jeffery L., Gilliland, D. Gary, Ebert, Benjamin L.

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Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis von Goessling, Wolfram, FitzGerald, Garret A, Bowman, Teresa V, Jang, Il-Ho, Kopani, Kamden R, Orkin, Stuart H, Lengerke, Claudia, North, Trista E, Daley, George Q, Walkley, Carl R, Weber, Gerhard J, Lord, Allegra M, Grosser, Tilo, Zon, Leonard I

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PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury von North, Trista E., Babu, I. Ramesh, Vedder, Lea M., Lord, Allegra M., Wishnok, John S., Tannenbaum, Steven R., Zon, Leonard I., Goessling, Wolfram

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Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion von Wojtowicz, Edyta E, Mistry, Jayna J, Uzun, Vladimir, Hellmich, Charlotte, Scoones, Anita, Chin, Desmond W, Kettyle, Laura M, Grasso, Francesca, Lord, Allegra M, Wright, David J, Etherington, Graham J, Woll, Petter S, Belderbos, Mirjam E, Bowles, Kristian M, Nerlov, Claus, Haerty, Wilfried, Bystrykh, Leonid V, Jacobsen, Sten Eirik W, Rushworth, Stuart A, Macaulay, Iain C

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APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development von Goessling, Wolfram, North, Trista E., Lord, Allegra M., Ceol, Craig, Lee, Sang, Weidinger, Gilbert, Bourque, Caitlin, Strijbosch, Robbert, Haramis, Anna-Pavlina, Puder, Mark, Clevers, Hans, Moon, Randall T., Zon, Leonard I.

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Prostaglandin E2: Making More of Your Marrow von Lord, Allegra M., North, Trista E., Zon, Leonard I.

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Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation von Obeng, Esther A., Chappell, Ryan J., Seiler, Michael, Chen, Michelle C., Campagna, Dean R., Schmidt, Paul J., Schneider, Rebekka K., Lord, Allegra M., Wang, Lili, Gambe, Rutendo G., McConkey, Marie E., Ali, Abdullah M., Raza, Azra, Yu, Lihua, Buonamici, Silvia, Smith, Peter G., Mullally, Ann, Wu, Catherine J., Fleming, Mark D., Ebert, Benjamin L.

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3227 – PARALLEL CLONAL AND MOLECULAR PROFILING OF HEMATOPOIETIC STEM CELLS USING RNA BARCODING von wojtowicz, edyta, Mistry, Jayna, Uzun, Vladimir, Scoones, Anita, Chin, Desmond, Kettyle, Laura, Lord, Allegra, Grasso, Francesca, Etherington, Graham, Hellmich, Charlotte, Woll, Petter, Belderbos, Mirjam, Bowles, Kristian, Bystrykh, Leonid, Nerlov, Claus, Haerty, Wilfried, Jacobsen, Sten Eirik, Rushworth, Stuart, Macaulay, Iain

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Abstract 3778: Genome-Scale CRISPRa and CRISPRi screening for lncRNA drivers of prostate cancer progression von Weiss, Simone, Lord, Allegra, Schmierer, Bernhard, Rovsing, Anne B., Thomsen, Emil A., Mikkelsen, Jacob G., Ulhøi, Benedicte, Pedersen, Jakob S., Borre, Michael, Sørensen, Karina D.

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3015 - Hierarchically Related Lineage-Restricted Fates of Multipotent Hematopoietic Stem Cells von Carrelha, Joana, Meng, Yiran, Kettyle, Laura, Luis, Tiago, Norfo, Ruggiero, Alcolea, Verónica, Boukarabila, Hanane, Grasso, Francesca, Gambardella, Adriana, Grover, Amit, Högstrand, Kari, Lord, Allegra, Sanjuan-Pla, Alejandra, Woll, Petter, Nerlov, Claus, Jacobsen, Sten Eirik

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MEGAKARYOCYTE-LINEAGE BIAS AND RESTRICTION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS von Carrelha, Joana, Meng, Yiran, Kettyle, Laura, Seki, Masafumi, Belander-Strålin, Karin, Luis, Tiago, Norfo, Ruggiero, Alcolea, Verónica, Boukarabila, Hanane, Grasso, Francesca, Gambardella, Adriana, Grover, Amit, Högstrand, Kari, Lord, Allegra, Sanjuan-Pla, Alejandra, Woll, Petter, Nerlov, Claus, Jacobsen, Sten Eirik

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Hierarchically Related Lineage-Restricted Fates of Multipotent Hematopoietic Stem Cells von Carrelha, Joana, Meng, Yiran, Kettyle, Laura, Luis, Tiago, Norfo, Ruggiero, Alcolea, Verónica, Boukarabila, Hanane, Grasso, Francesca, Gambardella, Adriana, Grover, Amit, Högstrand, Kari, Lord, Allegra, Sanjuan-Pla, Alejandra, Woll, Petter, Nerlov, Claus, Jacobsen, Sten Eirik

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Epigenetics of TET2 Loss in Myelodysplastic Syndromes von Lord, Allegra

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