DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts von Roulois, David, Loo Yau, Helen, Singhania, Rajat, Wang, Yadong, Danesh, Arnavaz, Shen, Shu Yi, Han, Han, Liang, Gangning, Jones, Peter A., Pugh, Trevor J., O’Brien, Catherine, De Carvalho, Daniel D.

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Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency von Mehdipour, Parinaz, Marhon, Sajid A., Ettayebi, Ilias, Chakravarthy, Ankur, Hosseini, Amir, Wang, Yadong, de Castro, Fabíola Attié, Loo Yau, Helen, Ishak, Charles, Abelson, Sagi, O’Brien, Catherine A., De Carvalho, Daniel D.

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Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression von Chen, Sujun, Zhu, Guanghui, Yang, Yue, Wang, Fubo, Xiao, Yu-Tian, Zhang, Na, Bian, Xiaojie, Zhu, Yasheng, Yu, Yongwei, Liu, Fei, Dong, Keqin, Mariscal, Javier, Liu, Yin, Soares, Fraser, Loo Yau, Helen, Zhang, Bo, Chen, Weidong, Wang, Chao, Chen, Dai, Guo, Qinghua, Yi, Zhengfang, Liu, Mingyao, Fraser, Michael, De Carvalho, Daniel D., Boutros, Paul C., Di Vizio, Dolores, Jiang, Zhou, van der Kwast, Theodorus, Berlin, Alejandro, Wu, Song, Wang, Jianhua, He, Housheng Hansen, Ren, Shancheng

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Spliceosome-Targeted Therapies Induce dsRNA Responses von Ishak, Charles A., Loo Yau, Helen, De Carvalho, Daniel D.

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The Cancer Epigenome: Exploiting Its Vulnerabilities for Immunotherapy von Loo Yau, Helen, Ettayebi, Ilias, De Carvalho, Daniel D.

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Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia von de Castro, Fabíola Attié, Mehdipour, Parinaz, Chakravarthy, Ankur, Ettayebi, Ilias, Loo Yau, Helen, Medina, Tiago Silva, Marhon, Sajid A, de Almeida, Felipe Campos, Bianco, Thiago Mantello, Arruda, Andrea G F, Devlin, Rebecca, de Figueiredo-Pontes, Lorena Lobo, Chahud, Fernando, da Costa Cacemiro, Maira, Minden, Mark D, Gupta, Vikas, De Carvalho, Daniel D

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An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors von Taylor, Kirsty, Loo Yau, Helen, Chakravarthy, Ankur, Wang, Ben, Shen, Shu Yi, Ettayebi, Ilias, Ishak, Charles A, Bedard, Philippe L, Abdul Razak, Albiruni, R Hansen, Aaron, Spreafico, Anna, Cescon, Dave, Butler, Marcus O, Oza, Amit M, Lheureux, Stephanie, Stjepanovic, Neda, Van As, Brendan, Boross-Harmer, Sarah, Wang, Lisa, Pugh, Trevor J, Ohashi, Pamela S, Siu, Lillian L, De Carvalho, Daniel D

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DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells von Loo Yau, Helen, Bell, Emma, Ettayebi, Ilias, de Almeida, Felipe Campos, Boukhaled, Giselle M., Shen, Shu Yi, Allard, David, Morancho, Beatriz, Marhon, Sajid A., Ishak, Charles A., Gonzaga, Isabela M., da Silva Medina, Tiago, Singhania, Rajat, Chakravarthy, Ankur, Chen, Raymond, Mehdipour, Parinaz, Pommey, Sandra, Klein, Christian, Amarante-Mendes, Gustavo P., Roulois, David, Arribas, Joaquín, Stagg, John, Brooks, David G., De Carvalho, Daniel D.

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Measuring the effect of drug treatments on primary human CD8+ T cell activation and cytolytic potential von Loo Yau, Helen, De Carvalho, Daniel D.

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Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways von Feng, Shengrui, Marhon, Sajid A., Sokolowski, Dustin J., D’Costa, Alister, Soares, Fraser, Mehdipour, Parinaz, Ishak, Charles, Loo Yau, Helen, Ettayebi, Ilias, Patel, Parasvi S., Chen, Raymond, Liu, Jiming, Zuzarte, Philip C., Ho, King Ching, Ho, Ben, Ning, Shiyao, Huang, Annie, Arrowsmith, Cheryl H., Wilson, Michael D., Simpson, Jared T., De Carvalho, Daniel D.

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B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity von Rahbar, Ramtin, Lin, Albert, Ghazarian, Magar, Yau, Helen-Loo, Paramathas, Sangeetha, Lang, Philipp A, Schildknecht, Anita, Elford, Alisha R, Garcia-Batres, Carlos, Martin, Bernard, Berman, Hal K, Leong, Wey L, McCready, David R, Reedijk, Michael, Done, Susan J, Miller, Naomi, Youngson, Bruce, Suh, Woong-Kyung, Mak, Tak W, Ohashi, Pamela S

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Method comparison of faecal elastase-1 test between Schebo and Liaison von Qu, Wenwen, van der Loo, Helen

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Evaluation of a BIO-FLASH chemiluminescent analyser for the detection of anti-DFS70 antibodies von Vu, Rezina, Van der Loo, Helen

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The comparison of three commercial rodent tissue indirect immunofluorescence assays for detection of anti-liver kidney microsomal type 1 autoantibodies and other tissue autoantibod... von Stockdill, Tyla, van der Loo, Helen

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Abstract B053: Characterizing the effects of the DNA methylation inhibitor 5-AZA-CdR during CD8 T cell expansion von Yau, Helen Loo

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“A morning cortisol is the most effective clinical predictor of short synacthen test outcome”: A tertiary care centre experience von Mathara Diddhenipothage, Shani A. D., Beck, Katharina J., Loo, Helen, Amiyangoda, Gayana K., Pofi, Riccardo, Tomlinson, Jeremy W., Pal, Aparna

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Publisher Correction: Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency von Mehdipour, Parinaz, Marhon, Sajid A., Ettayebi, Ilias, Chakravarthy, Ankur, Hosseini, Amir, Wang, Yadong, de Castro, Fabíola Attié, Yau, Helen Loo, Ishak, Charles, Abelson, Sagi, O’Brien, Catherine A., De Carvalho, Daniel D.

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The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids von Seneviratne, Ayesh K., Xu, Mingjing, Henao, Juan J. Aristizabal, Fajardo, Val A., Hao, Zhenyue, Voisin, Veronique, Xu, G. Wei, Hurren, Rose, Kim, S., MacLean, Neil, Wang, Xiaoming, Gronda, Marcela, Jeyaraju, Danny, Jitkova, Yulia, Ketela, Troy, Mullokandov, Michael, Sharon, David, Thomas, Geethu, Chouinard-Watkins, Raphaël, Hawley, James R., Schafer, Caitlin, Yau, Helen Loo, Khuchua, Zaza, Aman, Ahmed, Al-awar, Rima, Gross, Atan, Claypool, Steven M., Bazinet, Richard P., Lupien, Mathieu, Chan, Steven, De Carvalho, Daniel D., Minden, Mark D., Bader, Gary D., Stark, Ken D., LeBlanc, Paul, Schimmer, Aaron D.

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Pharmacological DNA demethylation: Implications for cancer immunotherapy von Roulois, David, Yau, Helen Loo, De Carvalho, Daniel D.

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Abstract CT190: A Phase II basket study of hypomethylating agent oral cc-486 and durvalumab in advanced solid tumors (METADUR) von Taylor, Kirsty, Yau, Helen Loo, Wang, Ben X., Bedard, Philippe L., Razak, Albiruni R., Hansen, Aaron R., Spreafico, Anna, Cescon, Dave, Butler, Marcus O., Oza, Amit M., Lheureux, Stephanie, Stjepanovic, Neda, Wang, Lisa, As, Brendan Van, Boross-Harmer, Sarah, Pugh, Trevor, Siu, Lillian L., Carvalho, Daniel D. De

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