Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1 von Schoepfer, Joseph, Jahnke, Wolfgang, Berellini, Giuliano, Buonamici, Silvia, Cotesta, Simona, Cowan-Jacob, Sandra W, Dodd, Stephanie, Drueckes, Peter, Fabbro, Doriano, Gabriel, Tobias, Groell, Jean-Marc, Grotzfeld, Robert M, Hassan, A. Quamrul, Henry, Chrystèle, Iyer, Varsha, Jones, Darryl, Lombardo, Franco, Loo, Alice, Manley, Paul W, Pellé, Xavier, Rummel, Gabriele, Salem, Bahaa, Warmuth, Markus, Wylie, Andrew A, Zoller, Thomas, Marzinzik, Andreas L, Furet, Pascal

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The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1 von Wylie, Andrew A., Schoepfer, Joseph, Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Loo, Alice, Furet, Pascal, Marzinzik, Andreas L., Pelle, Xavier, Donovan, Jerry, Zhu, Wenjing, Buonamici, Silvia, Hassan, A. Quamrul, Lombardo, Franco, Iyer, Varsha, Palmer, Michael, Berellini, Giuliano, Dodd, Stephanie, Thohan, Sanjeev, Bitter, Hans, Branford, Susan, Ross, David M., Hughes, Timothy P., Petruzzelli, Lilli, Vanasse, K. Gary, Warmuth, Markus, Hofmann, Francesco, Keen, Nicholas J., Sellers, William R.

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PTEN-deficient cancers depend on PIK3CB von Wee, Susan, Wiederschain, Dmitri, Maira, Sauveur-Michel, Loo, Alice, Miller, Christine, deBeaumont, Rosalie, Stegmeier, Frank, Yao, Yung-Mae, Lengauer, Christoph

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers von Wee, Susan, Jagani, Zainab, Xiang, Kay Xiaoqin, Loo, Alice, Dorsch, Marion, Yao, Yung-Mae, Sellers, William R, Lengauer, Christoph, Stegmeier, Frank

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Single-vector inducible lentiviral RNAi system for oncology target validation von Wiederschain, Dmitri, Susan, Wee, Chen, Lin, Loo, Alice, Yang, Guizhi, Huang, Alan, Chen, Yan, Caponigro, Giordano, Yao, Yung-mae, Lengauer, Christoph, Sellers, William R., Benson, John D.

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Protein Kinase C Inhibitor Sotrastaurin Selectively Inhibits the Growth of CD79 Mutant Diffuse Large B-Cell Lymphomas von NAYLOR, Tara L, HUAPING TANG, YAO, Yung-Mae, WARMUTH, Markus, LENZ, Georg, STEGMEIER, Frank, RATSCH, Boris A, ENNS, Andreas, LOO, Alice, LIQING CHEN, LENZ, Peter, WATERS, Nigel J, SCHULER, Walter, DÖRKEN, Bernd

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Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling von Scholer-Dahirel, Alix, Schlabach, Michael R, Loo, Alice, Bagdasarian, Linda, Meyer, Ronald, Guo, Ribo, Woolfenden, Steve, Yu, Kristine K, Markovits, Judit, Killary, Karen, Sonkin, Dmitry, Yao, Yung-Mae, Warmuth, Markus, Sellers, William R, Schlegel, Robert, Stegmeier, Frank, Mosher, Rebecca E, McLaughlin, Margaret E

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Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition von Fassl, Anne, Brain, Christopher, Abu-Remaileh, Monther, Stukan, Iga, Butter, Deborah, Stepien, Piotr, Feit, Avery S., Bergholz, Johann, Michowski, Wojciech, Otto, Tobias, Sheng, Qing, Loo, Alice, Michael, Walter, Tiedt, Ralph, DeAngelis, Carmine, Schiff, Rachel, Jiang, Baishan, Jovanovic, Bojana, Nowak, Karolina, Ericsson, Maria, Cameron, Michael, Gray, Nathanael, Dillon, Deborah, Zhao, Jean J., Sabatini, David M., Jeselsohn, Rinath, Brown, Myles, Polyak, Kornelia, Sicinski, Piotr

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The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells von JAGANI, Zainab, WIEDERSCHAIN, Dmitri, WARMUTH, Markus, SELLERS, William R, DORSCH, Marion, LOO, Alice, DAN HE, MOSHER, Rebecca, FORDJOUR, Paul, MONAHAN, John, MORRISSEY, Michael, YAO, Yung-Mae, LENGAUER, Christoph

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Abstract 872: In vivo activity of a novel CDH6 targeting antibody-drug conjugate, including population-scale ovarian PDX clinical trial von Bialucha, Carl U., Collins, Scott D., Shim, Yeonju, Zhang, Xiamei, Velazquez, Roberto, Kowal, Colleen, Bullock, Caroline, Cai, Hongbo, Rivera, Stacy M., Goldovitz, Julie M., Kurth, Esther, Loo, Alice T., Yang, Guizhi, Green, John, Ostrom, Lance, Meyer, Matthew J., Mosher, Rebecca, Gao, Hui, Williams, Juliet, Lees, Emma

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Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling von Liu, Chen, Lu, Hengyu, Wang, Hongyun, Loo, Alice, Zhang, Xiamei, Yang, Guizhi, Kowal, Colleen, Delach, Scott, Wang, Ye, Goldoni, Silvia, Hastings, William D., Wong, Karrie, Gao, Hui, Meyer, Matthew J., Moody, Susan E., LaMarche, Matthew J., Engelman, Jeffrey A., Williams, Juliet A., Hammerman, Peter S., Abrams, Tinya J., Mohseni, Morvarid, Caponigro, Giordano, Hao, Huai-Xiang

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Targeting HSF1 sensitizes cancer cells to HSP90 inhibition von Chen, Yaoyu, Chen, Jinyun, Loo, Alice, Jaeger, Savina, Bagdasarian, Linda, Yu, Jianjun, Chung, Franklin, Korn, Joshua, Ruddy, David, Guo, Ribo, Mclaughlin, Margaret E., Feng, Fei, Zhu, Ping, Stegmeier, Frank, Pagliarini, Raymond, Porter, Dale, Zhou, Wenlai

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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response von Gao, Hui, Korn, Joshua M, Ferretti, Stéphane, Monahan, John E, Wang, Youzhen, Singh, Mallika, Zhang, Chao, Schnell, Christian, Yang, Guizhi, Zhang, Yun, Balbin, O Alejandro, Barbe, Stéphanie, Cai, Hongbo, Casey, Fergal, Chatterjee, Susmita, Chiang, Derek Y, Chuai, Shannon, Cogan, Shawn M, Collins, Scott D, Dammassa, Ernesta, Ebel, Nicolas, Embry, Millicent, Green, John, Kauffmann, Audrey, Kowal, Colleen, Leary, Rebecca J, Lehar, Joseph, Liang, Ying, Loo, Alice, Lorenzana, Edward, Robert McDonald, E, McLaughlin, Margaret E, Merkin, Jason, Meyer, Ronald, Naylor, Tara L, Patawaran, Montesa, Reddy, Anupama, Röelli, Claudia, Ruddy, David A, Salangsang, Fernando, Santacroce, Francesca, Singh, Angad P, Tang, Yan, Tinetto, Walter, Tobler, Sonja, Velazquez, Roberto, Venkatesan, Kavitha, Von Arx, Fabian, Wang, Hui Qin, Wang, Zongyao, Wiesmann, Marion, Wyss, Daniel, Xu, Fiona, Bitter, Hans, Atadja, Peter, Lees, Emma, Hofmann, Francesco, Li, En, Keen, Nicholas, Cozens, Robert, Jensen, Michael Rugaard, Pryer, Nancy K, Williams, Juliet A, Sellers, William R

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The landscape of somatic copy-number alteration across human cancers von Yecies, Derek, Gabriel, Stacey, Porter, Dale, Nucera, Carmelo, Antonescu, Cristina R, Chiang, Derek Y, Janne, Pasi A, Greulich, Heidi, Loo, Alice, Prensner, John, Maher, Elizabeth, Rustgi, Anil K, Ligon, Azra H, Tanaka, Kumiko E, Kaye, Frederic J, Ebert, Benjamin L, Pomeroy, Scott L, Lander, Eric S, Fletcher, Jonathan A, Okamoto, Aikou, Signoretti, Sabina, Haery, Leila, Reich, Michael, Dobson, Jennifer, Raychaudhuri, Soumya, Wei, Guo, Baselga, José, Tsao, Ming-Sound, Letai, Anthony, Getz, Gad, Liefeld, Ted, Donovan, Jerry, Levine, Ross L, Beer, David G, Daly, Mark J, Sasaki, Hidefumi, Pinchback, Reid M, Bass, Adam J, Hoffman, Carter, Ladanyi, Marc, True, Lawrence D, Cho, Yoon-Jae, Sellers, William R, Tabernero, Josep, Demichelis, Francesca, Tepper, Joel E, Golub, Todd R, Meyerson, Matthew, Boehm, Jesse S, Mermel, Craig H, Loda, Massimo, Weir, Barbara A, Beroukhim, Rameen, Singer, Samuel, Urashima, Mitsuyoshi, Gao, Qing, Lawrence, Michael S, Rubin, Mark A, Barretina, Jordi, Garraway, Levi A, Winckler, Wendy, Mc Henry, Kevin T

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Correspondence on “Synergy and Antagonism between Allosteric and Active‐Site Inhibitors of Abl Tyrosine Kinase” von Jahnke, Wolfgang, Paladini, Johannes, Habazettl, Judith M., Wiget, Andrea, Loo, Alice, Cowan Jacob, Sandra W., Grzesiek, Stephan, Manley, Paul W.

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Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo von Zhang, Yi-Xiang, Sicinska, Ewa, Czaplinski, Jeffrey T, Remillard, Stephen P, Moss, Samuel, Wang, Yuchuan, Brain, Christopher, Loo, Alice, Snyder, Eric L, Demetri, George D, Kim, Sunkyu, Kung, Andrew L, Wagner, Andrew J

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The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models von Kim, Sunkyu, Tiedt, Ralph, Loo, Alice, Horn, Thomas, Delach, Scott, Kovats, Steven, Haas, Kristy, Engstler, Barbara Schacher, Cao, Alexander, Pinzon-Ortiz, Maria, Mulford, Iain, Acker, Michael G, Chopra, Rajiv, Brain, Christopher, di Tomaso, Emmanuelle, Sellers, William R, Caponigro, Giordano

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Structural and Biochemical Studies Confirming the Mechanism of Action of Asciminib, an Agent Specifically Targeting the ABL Myristoyl Pocket (STAMP) von Schuld, Peter, Grzesiek, Stephan, Schlotte, Johannes, Habazettl, Judith M, Jahnke, Wolfgang, Barys, Louise, Cowan-Jacob, Sandra W, Loo, Alice, Wiget, Andrea, Manley, Paul W.

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Change in quality of life from before to after discharge following left ventricular assist device implantation von Grady, Kathleen L, Meyer, Peter M, Mattea, Annette, Dressler, Diane, Ormaza, Sophia, White-Williams, Connie, Chillcott, Suzanne, Kaan, Annemarie, Loo, Alice, Todd, Barbara, Klemme, Annette, Piccione, William, Costanzo, Maria Rosa

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AST/ALT ratio ≥1 is not diagnostic of cirrhosis in patients with chronic hepatitis C von REEDY, D. W, LOO, A. T, LEVINE, R. A

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