Molecular mechanisms of drug resistance von Longley, DB, Johnston, PG

Volltext

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death von LONGLEY, D. B, WILSON, T. R, MCEWAN, M, ALLEN, W. L, MCDERMOTT, U, GALLIGAN, L, JOHNSTON, P. G

Volltext

Chemoresistance in solid tumours von Wilson, T.R., Longley, D.B., Johnston, P.G.

Volltext

Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer von Turkington, R C, Longley, D B, Allen, W L, Stevenson, L, McLaughlin, K, Dunne, P D, Blayney, J K, Salto-Tellez, M, Van Schaeybroeck, S, Johnston, P G

Volltext

Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy von Smyth, P, Ferguson, L, Burrows, J F, Burden, R E, Tracey, S R, Herron, Ú M, Kovaleva, M, Williams, R, Porter, A J, Longley, D B, Barelle, C J, Scott, C J

Volltext

Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly von Majkut, J., Sgobba, M., Holohan, C., Crawford, N., Logan, A. E., Kerr, E., Higgins, C. A., Redmond, K. L., Riley, J. S., Stasik, I., Fennell, D. A., Van Schaeybroeck, S., Haider, S., Johnston, P. G., Haigh, D., Longley, D. B.

Volltext

Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer von Riley, J S, Hutchinson, R, McArt, D G, Crawford, N, Holohan, C, Paul, I, Van Schaeybroeck, S, Salto-Tellez, M, Johnston, P G, Fennell, D A, Gately, K, O'Byrne, K, Cummins, R, Kay, E, Hamilton, P, Stasik, I, Longley, D B

Volltext

Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells von Wilson, T R, McEwan, M, McLaughlin, K, Le Clorennec, C, Allen, W L, Fennell, D A, Johnston, P G, Longley, D B

Volltext

Procaspase 8 overexpression in non-small-cell lung cancer promotes apoptosis induced by FLIP silencing von Wilson, T R, Redmond, K M, McLaughlin, K M, Crawford, N, Gately, K, O'Byrne, K, Le-Clorrenec, C, Holohan, C, Fennell, D A, Johnston, P G, Longley, D B

Volltext

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma von Crawford, N, Stasik, I, Holohan, C, Majkut, J, McGrath, M, Johnston, P G, Chessari, G, Ward, G A, Waugh, D J, Fennell, D A, Longley, D B

Volltext

5-Fluorouracil: mechanisms of action and clinical strategies von Johnston, Patrick G, Longley, Daniel B, Harkin, D. Paul

Volltext

DED or alive: assembly and regulation of the death effector domain complexes von Riley, J S, Malik, A, Holohan, C, Longley, D B

Volltext

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis von Kerr, E, Holohan, C, McLaughlin, K M, Majkut, J, Dolan, S, Redmond, K, Riley, J, McLaughlin, K, Stasik, I, Crudden, M, Van Schaeybroeck, S, Fenning, C, O'Connor, R, Kiely, P, Sgobba, M, Haigh, D, Johnston, P G, Longley, D B

Volltext

Molecular and biochemical markers in colorectal cancer von McDermott, U., Longley, D. B., Johnston, P. G.

Volltext

Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma von WONG, N. A. C. S, BRETT, L, STEWART, M, LEITCH, A, LONGLEY, D. B, DUNLOP, M. G, JOHNSTON, P. G, LESSELLS, A. M, JODRELL, D. I

Volltext

Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity von Schmid, D, Jarvis, G E, Fay, F, Small, D M, Greene, M K, Majkut, J, Spence, S, McLaughlin, K M, McCloskey, K D, Johnston, P G, Kissenpfennig, A, Longley, D B, Scott, C J

Volltext

Characterization of a thymidylate synthase (TS)-inducible cell line : A model system for studying sensitivity to TS- and non-TS-targeted chemotherapies von LONGLEY, Daniel B, FERGUSON, Paul R, BOYER, John, LATIF, Tariq, LYNCH, Maria, MAXWELL, Pamela, HARKIN, D. Paul, JOHNSTON, Patrick G

Volltext

Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer von Paul, I, Chacko, A D, Stasik, I, Busacca, S, Crawford, N, McCoy, F, McTavish, N, Wilson, B, Barr, M, O'Byrne, K J, Longley, D B, Fennell, D A

Volltext

Clinical significance of prognostic and predictive markers in colorectal cancer von LONGLEY, D. B, MCDERMOTT, U, JOHNSTON, P. G

Volltext

The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates von LONGLEY, Daniel B, BOYER, John, ALLEN, Wendy L, LATIF, Tariq, FERGUSON, Paul R, MAXWELL, Pamela J, MCDERMOTT, Ultan, LYNCH, Maria, HARKIN, D. Paul, JOHNSTON, Patrick G

Volltext