Conformational pathology of the serpins: themes, variations, and therapeutic strategies von Gooptu, Bibek, Lomas, David A

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Endoplasmic reticulum dysfunction in neurological disease von Roussel, Benoit D, PhD, Kruppa, Antonina J, PhD, Miranda, Elena, PhD, Crowther, Damian C, PhD, Lomas, David A, Prof, Marciniak, Stefan J, Dr

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Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease von Hurst, John R, Vestbo, Jørgen, Anzueto, Antonio, Locantore, Nicholas, Müllerova, Hana, Tal-Singer, Ruth, Miller, Bruce, Lomas, David A, Agusti, Alvar, MacNee, William, Calverley, Peter, Rennard, Stephen, Wouters, Emiel F.M, Wedzicha, Jadwiga A

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Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype von Agustí, Alvar, Edwards, Lisa D, Rennard, Stephen I, MacNee, William, Tal-Singer, Ruth, Miller, Bruce E, Vestbo, Jørgen, Lomas, David A, Calverley, Peter M A, Wouters, Emiel, Crim, Courtney, Yates, Julie C, Silverman, Edwin K, Coxson, Harvey O, Bakke, Per, Mayer, Ruth J, Celli, Bartolome

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A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci von Pillai, Sreekumar G, Ge, Dongliang, Zhu, Guohua, Kong, Xiangyang, Shianna, Kevin V, Need, Anna C, Feng, Sheng, Hersh, Craig P, Bakke, Per, Gulsvik, Amund, Ruppert, Andreas, Lødrup Carlsen, Karin C, Roses, Allen, Anderson, Wayne, Rennard, Stephen I, Lomas, David A, Silverman, Edwin K, Goldstein, David B

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Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells von Yusa, Kosuke, Rashid, S. Tamir, Strick-Marchand, Helene, Varela, Ignacio, Liu, Pei-Qi, Paschon, David E., Miranda, Elena, Ordóñez, Adriana, Hannan, Nicholas R. F., Rouhani, Foad J., Darche, Sylvie, Alexander, Graeme, Marciniak, Stefan J., Fusaki, Noemi, Hasegawa, Mamoru, Holmes, Michael C., Di Santo, James P., Lomas, David A., Bradley, Allan, Vallier, Ludovic

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Changes in Forced Expiratory Volume in 1 Second over Time in COPD von Vestbo, Jørgen, Edwards, Lisa D, Scanlon, Paul D, Yates, Julie C, Agusti, Alvar, Bakke, Per, Calverley, Peter M.A, Celli, Bartolome, Coxson, Harvey O, Crim, Courtney, Lomas, David A, MacNee, William, Miller, Bruce E, Silverman, Edwin K, Tal-Singer, Ruth, Wouters, Emiel, Rennard, Stephen I

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Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease von CELLI, Bartolome R, LOCANTORE, Nicholas, LOMAS, David A, DUVOIX, Annelyse, MACNEE, William, RENNARD, Stephen, SILVERMAN, Edwin, VESTBO, Jørgen, WOUTERS, Emiel, AGUSTI, Alvar, YATES, Julie, TAL-SINGER, Ruth, MILLER, Bruce E, BAKKE, Per, CALVERLEY, Peter, COXSON, Harvey, CRIM, Courtney, EDWARDS, Lisa D

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Characterisation of COPD heterogeneity in the ECLIPSE cohort von Agusti, Alvar, Calverley, Peter M A, Celli, Bartolome, Coxson, Harvey O, Edwards, Lisa D, Lomas, David A, MacNee, William, Miller, Bruce E, Rennard, Steve, Silverman, Edwin K, Tal-Singer, Ruth, Wouters, Emiel, Yates, Julie C, Vestbo, Jørgen

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High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin von Jagger, Alistair M., Waudby, Christopher A., Irving, James A., Christodoulou, John, Lomas, David A.

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The Effect of Inhaled Corticosteroid Withdrawal and Baseline Inhaled Treatment on Exacerbations in the IMPACT Study A Randomized, Double-Blind, Multicenter Clinical Trial von Han, MeiLan K., Criner, Gerard J., Dransfield, Mark T., Halpin, David M. G., Jones, C. Elaine, Kilbride, Sally, Lange, Peter, Lettis, Sally, Lipson, David A., Lomas, David A., Martin, Neil, Wise, Robert A., Singh, Dave, Martinez, Fernando J.

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Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort von Miller, Joy, Edwards, Lisa D, Agustí, Alvar, Bakke, Per, Calverley, Peter M.A, Celli, Bartolome, Coxson, Harvey O, Crim, Courtney, Lomas, David A, Miller, Bruce E, Rennard, Steve, Silverman, Edwin K, Tal-Singer, Ruth, Vestbo, Jørgen, Wouters, Emiel, Yates, Julie C, MacNee, William

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Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort von AGUSTI, Alvar, EDWARDS, Lisa D, CRIM, Courtney, MILLER, Bruce E, COXSON, Harvey O, YATES, Julie C, TAL-SINGER, Ruth, VESTBO, Jørgen, CELLI, Bartolomé, MACNEE, William, CALVERLEY, Peter M. A, MÜLLEROVA, Hana, LOMAS, David A, WOUTERS, Emiel, BAKKE, Per, RENNARD, Steve

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COPD association and repeatability of blood biomarkers in the ECLIPSE cohort von Dickens, Jennifer A, Miller, Bruce E, Edwards, Lisa D, Silverman, Edwin K, Lomas, David A, Tal-Singer, Ruth

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Circulating soluble receptor for advanced glycation end products (sRAGE) as a biomarker of emphysema and the RAGE axis in the lung von Yonchuk, John G, Silverman, Edwin K, Bowler, Russell P, Agustí, Alvar, Lomas, David A, Miller, Bruce E, Tal-Singer, Ruth, Mayer, Ruth J

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It's more than low BMI: prevalence of cachexia and associated mortality in COPD von McDonald, Merry-Lynn N, Wouters, Emiel F M, Rutten, Erica, Casaburi, Richard, Rennard, Stephen I, Lomas, David A, Bamman, Marcas, Celli, Bartolome, Agusti, Alvar, Tal-Singer, Ruth, Hersh, Craig P, Dransfield, Mark, Silverman, Edwin K

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The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study von Coxson, Harvey O, PhD, Dirksen, Asger, DrMedSc, Edwards, Lisa D, PhD, Yates, Julie C, BS, Agusti, Alvar, MD, Bakke, Per, PhD, Calverley, Peter MA, MD, Celli, Bartolome, MD, Crim, Courtney, MD, Duvoix, Annelyse, PhD, Fauerbach, Paola Nasute, MD, Lomas, David A, MD, MacNee, William, MD, Mayer, Ruth J, PhD, Miller, Bruce E, PhD, Müller, Nestor L, MD, Rennard, Stephen I, MD, Silverman, Edwin K, MD, Tal-Singer, Ruth, PhD, Wouters, Emiel FM, MD, Vestbo, Jørgen, DrMedSc

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The effect of exacerbation history on outcomes in the IMPACT trial von Halpin, David M. G., Dransfield, Mark T., Han, MeiLan K., Jones, C. Elaine, Kilbride, Sally, Lange, Peter, Lipson, David A., Lomas, David A., Martinez, Fernando J., Pascoe, Steve, Singh, Dave, Wise, Robert, Criner, Gerard J.

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Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease von Albert, Paul, Agusti, Alvar, Edwards, Lisa, Tal-Singer, Ruth, Yates, Julie, Bakke, Per, Celli, Bartolome R, Coxson, Harvey O, Crim, Courtney, Lomas, David A, MacNee, William, Miller, Bruce, Rennard, Stephen, Silverman, Edwin K, Vestbo, Jørgen, Wouters, Emiel, Calverley, Peter

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hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency von Segeritz, Charis-Patricia, Rashid, Sheikh Tamir, de Brito, Miguel Cardoso, Serra, Maria Paola, Ordonez, Adriana, Morell, Carola Maria, Kaserman, Joseph E., Madrigal, Pedro, Hannan, Nicholas R.F., Gatto, Laurent, Tan, Lu, Wilson, Andrew A., Lilley, Kathryn, Marciniak, Stefan J., Gooptu, Bibek, Lomas, David A., Vallier, Ludovic

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