Targeting the DNA Repair Enzyme Polymerase θ in Cancer Therapy von Schrempf, Anna, Slyskova, Jana, Loizou, Joanna I

Volltext

DNA replication stress: Causes, resolution and disease von Mazouzi, Abdelghani, Velimezi, Georgia, Loizou, Joanna I.

Volltext

Leveraging homologous recombination repair deficiency in sarcoma von Slade, Dea, Loizou, Joanna I

Volltext

Interplay between Cellular Metabolism and the DNA Damage Response in Cancer von Moretton, Amandine, Loizou, Joanna I.

Volltext

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy von Huber, Kilian V. M., Salah, Eidarus, Radic, Branka, Gridling, Manuela, Elkins, Jonathan M., Stukalov, Alexey, Jemth, Ann-Sofie, Göktürk, Camilla, Sanjiv, Kumar, Strömberg, Kia, Pham, Therese, Berglund, Ulrika Warpman, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna I., Helleday, Thomas, Knapp, Stefan, Superti-Furga, Giulio

Volltext

Validating the concept of mutational signatures with isogenic cell models von Zou, Xueqing, Owusu, Michel, Harris, Rebecca, Jackson, Stephen P., Loizou, Joanna I., Nik-Zainal, Serena

Volltext

Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR‐based screens von Wilson, Jordan, Loizou, Joanna I.

Volltext

Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing von Meyenberg, Mathilde, Ferreira da Silva, Joana, Loizou, Joanna I

Volltext

Tissue specificity of DNA repair: the CRISPR compass von Ferreira da Silva, Joana, Meyenberg, Mathilde, Loizou, Joanna I.

Volltext

FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair von Kratz, Katja, Artola-Borán, Mariela, Kobayashi-Era, Saho, Koh, Gene, Oliveira, Goncalo, Kobayashi, Shunsuke, Oliveira, Andreia, Zou, Xueqing, Richter, Julia, Tsuda, Masataka, Sasanuma, Hiroyuki, Takeda, Shunichi, Loizou, Joanna I., Sartori, Alessandro A., Nik-Zainal, Serena, Jiricny, Josef

Volltext

BioProfiling.jl: profiling biological perturbations with high-content imaging in single cells and heterogeneous populations von Vulliard, Loan, Hancock, Joel, Kamnev, Anton, Fell, Christopher W, Ferreira da Silva, Joana, Loizou, Joanna I, Nagy, Vanja, Dupré, Loïc, Menche, Jörg

Volltext

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability von Moretton, Amandine, Kourtis, Savvas, Gañez Zapater, Antoni, Calabrò, Chiara, Espinar Calvo, Maria Lorena, Fontaine, Frédéric, Darai, Evangelia, Abad Cortel, Etna, Block, Samuel, Pascual‐Reguant, Laura, Pardo‐Lorente, Natalia, Ghose, Ritobrata, Vander Heiden, Matthew G, Janic, Ana, Müller, André C, Loizou, Joanna I, Sdelci, Sara

Volltext

Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress von Conde, Cecilia Domínguez, Petronczki, Özlem Yüce, Baris, Safa, Willmann, Katharina L, Girardi, Enrico, Salzer, Elisabeth, Weitzer, Stefan, Ardy, Rico Chandra, Krolo, Ana, Ijspeert, Hanna, Kiykim, Ayca, Karakoc-Aydiner, Elif, Förster-Waldl, Elisabeth, Kager, Leo, Pickl, Winfried F, Superti-Furga, Giulio, Martínez, Javier, Loizou, Joanna I, Ozen, Ahmet, van der Burg, Mirjam, Boztug, Kaan

Volltext

Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks von Herceg, Zdenko, Murr, Rabih, Loizou, Joanna I, Yang, Yun-Gui, Cuenin, Cyrille, Li, Hai, Wang, Zhao-Qi

Volltext

Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis von Serwas, Nina K., Hoeger, Birgit, Ardy, Rico C., Stulz, Sigrun V., Sui, Zhenhua, Memaran, Nima, Meeths, Marie, Krolo, Ana, Yüce Petronczki, Özlem, Pfajfer, Laurène, Hou, Tie Z., Halliday, Neil, Santos-Valente, Elisangela, Kalinichenko, Artem, Kennedy, Alan, Mace, Emily M., Mukherjee, Malini, Tesi, Bianca, Schrempf, Anna, Pickl, Winfried F., Loizou, Joanna I., Kain, Renate, Bidmon-Fliegenschnee, Bettina, Schickel, Jean-Nicolas, Glauzy, Salomé, Huemer, Jakob, Garncarz, Wojciech, Salzer, Elisabeth, Pierides, Iro, Bilic, Ivan, Thiel, Jens, Priftakis, Peter, Banerjee, Pinaki P., Förster-Waldl, Elisabeth, Medgyesi, David, Huber, Wolf-Dietrich, Orange, Jordan S., Meffre, Eric, Sansom, David M., Bryceson, Yenan T., Altman, Amnon, Boztug, Kaan

Volltext

Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease von Prochazkova, Jana, Loizou, Joanna I.

Volltext

Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities von Unterhauser, Katrin, Pöltl, Lisa, Schneditz, Georg, Kienesberger, Sabine, Glabonjat, Ronald A., Kitsera, Maksym, Pletz, Jakob, Josa-Prado, Fernando, Dornisch, Elisabeth, Lembacher-Fadum, Christian, Roier, Sandro, Gorkiewicz, Gregor, Lucena, Daniel, Barasoain, Isabel, Kroutil, Wolfgang, Wiedner, Marc, Loizou, Joanna I., Breinbauer, Rolf, Díaz, José Fernando, Schild, Stefan, Högenauer, Christoph, Zechner, Ellen L.

Volltext

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN von Mazouzi, Abdelghani, Stukalov, Alexey, Müller, André C., Chen, Doris, Wiedner, Marc, Prochazkova, Jana, Chiang, Shih-Chieh, Schuster, Michael, Breitwieser, Florian P., Pichlmair, Andreas, El-Khamisy, Sherif F., Bock, Christoph, Kralovics, Robert, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna I.

Volltext

Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH von Mazouzi, Abdelghani, Battistini, Federica, Moser, Sarah C., Ferreira da Silva, Joana, Wiedner, Marc, Owusu, Michel, Lardeau, Charles-Hugues, Ringler, Anna, Weil, Beatrix, Neesen, Jürgen, Orozco, Modesto, Kubicek, Stefan, Loizou, Joanna I.

Volltext

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48 von Velimezi, Georgia, Robinson-Garcia, Lydia, Muñoz-Martínez, Francisco, Wiegant, Wouter W., Ferreira da Silva, Joana, Owusu, Michel, Moder, Martin, Wiedner, Marc, Rosenthal, Sara Brin, Fisch, Kathleen M., Moffat, Jason, Menche, Jörg, van Attikum, Haico, Jackson, Stephen P., Loizou, Joanna I.

Volltext