Composition of sediment records late Quaternary paleogeographic evolution of Santa Clara Valley, California von Andersen, David W, Shostak, Nancy C, Locke, Karen M, Ramstetter, Nathan P, Metzger, Ellen P

Volltext

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps von Mahajan, Anubha, Taliun, Daniel, Thurner, Matthias, Robertson, Neil R., Torres, Jason M., Rayner, N. William, Payne, Anthony J., Steinthorsdottir, Valgerdur, Scott, Robert A., Grarup, Niels, Schmidt, Ellen M., Wuttke, Matthias, Sarnowski, Chloé, Mägi, Reedik, Nano, Jana, Gieger, Christian, Trompet, Stella, Lecoeur, Cécile, Preuss, Michael H., Prins, Bram Peter, Guo, Xiuqing, Bielak, Lawrence F., Below, Jennifer E., Bowden, Donald W., Kim, Young Jin, Petty, Lauren E., Sim, Xueling, Bennett, Amanda J., Bork-Jensen, Jette, Brummett, Chad M., Canouil, Mickaël, Ec kardt, Kai-Uwe, Fischer, Krista, Kardia, Sharon L. R., Kronenberg, Florian, Läll, Kristi, Luan, Jian’an, Ntalla, Ioanna, Nylander, Vibe, Schönherr, Sebastian, Schurmann, Claudia, Yengo, Loïc, Bottinger, Erwin P., Brandslund, Ivan, Christensen, Cramer, Dedoussis, George, Florez, Jose C., Ford, Ian, Franco, Oscar H., Frayling, Timothy M., Giedraitis, Vilmantas, Hackinger, Sophie, Hattersley, Andrew T., Herder, Christian, Ikram, M. Arfan, Jørgensen, Marit E., Jørgensen, Torben, Kriebel, Jennifer, Kuusisto, Johanna, Ligthart, Symen, Linneberg, Allan, Lyssenko, Valeriya, Mamakou, Vasiliki, Meitinger, Thomas, Morris, Andrew D., Nadkarni, Girish, Pankow, James S., Peters, Annette, Sattar, Naveed, Stančáková, Alena, Strauch, Konstantin, Taylor, Kent D., Thorand, Barbara, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tuomilehto, Jaakko, Witte, Daniel R., Dupuis, Josée, Peyser, Patricia A., Zeggini, Eleftheria, Froguel, Philippe, Ingelsson, Erik, Lind, Lars, Laakso, Markku, Collins, Francis S., Jukema, J. Wouter, Grallert, Harald, Metspalu, Andres, Köttgen, Anna, Abecasis, Goncalo R., Meigs, James B., Rotter, Jerome I., Marchini, Jonathan, Hansen, Torben, Langenberg, Claudia, Wareham, Nicholas J., Stefansson, Kari, Morris, Andrew P., Boehnke, Michael, McCarthy, Mark I.

Volltext

How many steps/day are enough? For older adults and special populations von Tudor-Locke, Catrine, Craig, Cora L, Aoyagi, Yukitoshi, Bell, Rhonda C, Croteau, Karen A, De Bourdeaudhuij, Ilse, Ewald, Ben, Gardner, Andrew W, Hatano, Yoshiro, Lutes, Lesley D, Matsudo, Sandra M, Ramirez-Marrero, Farah A, Rogers, Laura Q, Rowe, David A, Schmidt, Michael D, Tully, Mark A, Blair, Steven N

Volltext

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study von Davis, James P, Huyghe, Jeroen R, Locke, Adam E, Jackson, Anne U, Sim, Xueling, Stringham, Heather M, Teslovich, Tanya M, Welch, Ryan P, Fuchsberger, Christian, Narisu, Narisu, Chines, Peter S, Kangas, Antti J, Soininen, Pasi, Ala-Korpela, Mika, Kuusisto, Johanna, Collins, Francis S, Laakso, Markku, Boehnke, Michael, Mohlke, Karen L

Volltext

Patient experiences of acute myeloid leukemia: A qualitative study about diagnosis, illness understanding, and treatment decision‐making von LeBlanc, Thomas W., Fish, Laura J., Bloom, Catherine T., El‐Jawahri, Areej, Davis, Debra M., Locke, Susan C., Steinhauser, Karen E., Pollak, Kathryn I.

Volltext

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci von Yin, Xianyong, Chan, Lap Sum, Bose, Debraj, Jackson, Anne U., VandeHaar, Peter, Locke, Adam E., Fuchsberger, Christian, Stringham, Heather M., Welch, Ryan, Yu, Ketian, Fernandes Silva, Lilian, Service, Susan K., Zhang, Daiwei, Hector, Emily C., Young, Erica, Ganel, Liron, Das, Indraniel, Abel, Haley, Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Wagner, Gregory R., Kang, Jian, Morrison, Jean, Burant, Charles F., Collins, Francis S., Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Mohlke, Karen L., Scott, Laura J., Wen, Xiaoquan, Fauman, Eric B., Laakso, Markku, Boehnke, Michael

Volltext

Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents von Tari, Leslie W, Li, Xiaoming, Trzoss, Michael, Bensen, Daniel C, Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Lee, Suk Joong, Hough, Grayson, Phillipson, Doug, Akers-Rodriguez, Suzanne, Cunningham, Mark L, Kwan, Bryan P, Nelson, Kirk J, Castellano, Amanda, Locke, Jeff B, Brown-Driver, Vickie, Murphy, Timothy M, Ong, Voon S, Pillar, Chris M, Shinabarger, Dean L, Nix, Jay, Lightstone, Felice C, Wong, Sergio E, Nguyen, Toan B, Shaw, Karen J, Finn, John

Volltext

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus von Mahajan, Anubha, Sim, Xueling, Ng, Hui Jin, Manning, Alisa, Rivas, Manuel A, Highland, Heather M, Locke, Adam E, Grarup, Niels, Im, Hae Kyung, Cingolani, Pablo, Flannick, Jason, Fontanillas, Pierre, Fuchsberger, Christian, Gaulton, Kyle J, Teslovich, Tanya M, Rayner, N William, Robertson, Neil R, Beer, Nicola L, Rundle, Jana K, Bork-Jensen, Jette, Ladenvall, Claes, Blancher, Christine, Buck, David, Buck, Gemma, Burtt, Noël P, Gabriel, Stacey, Gjesing, Anette P, Groves, Christopher J, Hollensted, Mette, Huyghe, Jeroen R, Jackson, Anne U, Jun, Goo, Justesen, Johanne Marie, Mangino, Massimo, Murphy, Jacquelyn, Neville, Matt, Onofrio, Robert, Small, Kerrin S, Stringham, Heather M, Syvänen, Ann-Christine, Trakalo, Joseph, Abecasis, Goncalo, Bell, Graeme I, Blangero, John, Cox, Nancy J, Duggirala, Ravindranath, Hanis, Craig L, Seielstad, Mark, Wilson, James G, Christensen, Cramer, Brandslund, Ivan, Rauramaa, Rainer, Surdulescu, Gabriela L, Doney, Alex S F, Lannfelt, Lars, Linneberg, Allan, Isomaa, Bo, Tuomi, Tiinamaija, Jørgensen, Marit E, Jørgensen, Torben, Kuusisto, Johanna, Uusitupa, Matti, Salomaa, Veikko, Spector, Timothy D, Morris, Andrew D, Palmer, Colin N A, Collins, Francis S, Mohlke, Karen L, Bergman, Richard N, Ingelsson, Erik, Lind, Lars, Tuomilehto, Jaakko, Hansen, Torben, Watanabe, Richard M, Prokopenko, Inga, Dupuis, Josee, Karpe, Fredrik, Groop, Leif, Laakso, Markku, Pedersen, Oluf, Florez, Jose C, Morris, Andrew P, Altshuler, David, Meigs, James B, Boehnke, Michael, McCarthy, Mark I, Lindgren, Cecilia M, Gloyn, Anna L

Volltext

Desensitization in HLA-Incompatible Kidney Recipients and Survival von Montgomery, Robert A, Lonze, Bonnie E, King, Karen E, Kraus, Edward S, Kucirka, Lauren M, Locke, Jayme E, Warren, Daniel S, Simpkins, Christopher E, Dagher, Nabil N, Singer, Andrew L, Zachary, Andrea A, Segev, Dorry L

Volltext

Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk von Yin, Xianyong, Bose, Debraj, Kwon, Annie, Hanks, Sarah C., Jackson, Anne U., Stringham, Heather M., Welch, Ryan, Oravilahti, Anniina, Fernandes Silva, Lilian, Locke, Adam E., Fuchsberger, Christian, Service, Susan K., Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Morrison, Jean, Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Collins, Francis S., Mohlke, Karen L., Scott, Laura J., Fauman, Eric B., Burant, Charles, Boehnke, Michael, Laakso, Markku, Wen, Xiaoquan

Volltext

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences von Spracklen, Cassandra N, Iyengar, Apoorva K, Vadlamudi, Swarooparani, Raulerson, Chelsea K, Jackson, Anne U, Brotman, Sarah M, Wu, Ying, Cannon, Maren E, Davis, James P, Crain, Aaron T, Currin, Kevin W, Perrin, Hannah J, Narisu, Narisu, Stringham, Heather M, Fuchsberger, Christian, Locke, Adam E, Welch, Ryan P, Kuusisto, Johanna K, Pajukanta, Päivi, Scott, Laura J, Li, Yun, Collins, Francis S, Boehnke, Michael, Laakso, Markku, Mohlke, Karen L

Volltext

Dissecting the Association Between Metabolic Syndrome and Prostate Cancer Risk: Analysis of a Large Clinical Cohort von Bhindi, Bimal, Locke, Jennifer, Alibhai, Shabbir M.H, Kulkarni, Girish S, Margel, David S, Hamilton, Robert J, Finelli, Antonio, Trachtenberg, John, Zlotta, Alexandre R, Toi, Ants, Hersey, Karen M, Evans, Andrew, van der Kwast, Theodorus H, Fleshner, Neil E

Volltext

Low Fitness Cost of the Multidrug Resistance Gene cfr von LAMARRE, Jacqueline M, LOCKE, Jeffrey B, SHAW, Karen J, MANKIN, Alexander S

Volltext

Translating physical activity recommendations into a pedometer-based step goal: 3000 steps in 30 minutes von Marshall, Simon J, Levy, Susan S, Tudor-Locke, Catrine E, Kolkhorst, Fred W, Wooten, Karen M, Ji, Ming, Macera, Caroline A, Ainsworth, Barbara E

Volltext

Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution von Wu, Ying, Broadaway, K Alaine, Raulerson, Chelsea K, Scott, Laura J, Pan, Calvin, Ko, Arthur, He, Aiqing, Tilford, Charles, Fuchsberger, Christian, Locke, Adam E, Stringham, Heather M, Jackson, Anne U, Narisu, Narisu, Kuusisto, Johanna, Pajukanta, Päivi, Collins, Francis S, Boehnke, Michael, Laakso, Markku, Lusis, Aldons J, Civelek, Mete, Mohlke, Karen L

Volltext

New genetic loci link adipose and insulin biology to body fat distribution von Ferreira, Teresa, Locke, Adam E., Justice, Anne E., Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Drong, Alexander W., Gustafsson, Stefan, Fall, Tove, Scherag, André, Absher, Devin, Ehret, Georg B., Kleber, Marcus E., Peters, Marjolein J., Albrecht, Eva, Bellis, Claire, Böhringer, Stefan, Böttcher, Yvonne, Clarke, Robert, Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Hallmans, Goran, Hassinen, Maija, Hunt, Steven C., Koenig, Wolfgang, Kratzer, Wolfgang, Lindström, Jaana, Merger, Sigrun, Mihailov, Evelin, Mills, Rebecca, Moayyeri, Alireza, Müller-Nurasyid, Martina, Nalls, Michael A., Narisu, Narisu, Nolte, Ilja M., Sanna, Serena, Seufferlein, Thomas, Wennauer, Roman, Choi, Murim, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Lifton, Richard P., Ma, Baoshan, Nicholson, George, Schadt, Eric E., Scott, Robert A., Westra, Harm-Jan, Beilby, John, Bergman, Richard N., Brown, Morris J., Campbell, Harry, Danesh, John, de Geus, Eco J. C., Ferrannini, Ele, Ferrières, Jean, Haiman, Christopher A., Johansen, Berit, Jousilahti, Pekka, Keinanen-Kiukaanniemi, Sirkka M., Kooperberg, Charles, Kumari, Meena, Matise, Tara C., Möhlenkamp, Stefan, Nelis, Mari, Ong, Ken K., Palmer, Lyle J., Ritchie, Marylyn D., Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Strauch, Konstantin, Boehm, Bernhard O., Chambers, John C., Grabe, Hans-Jörgen, Hamsten, Anders, Kivimaki, Mika, März, Winfried, Pedersen, Nancy L., Pérusse, Louis, Power, Chris, Rauramaa, Rainer, Rivadeneira, Fernando, Thorsteinsdottir, Unnur, Stumvoll, Michael, Watkins, Hugh, Wichmann, H-Erich, Hunter, David J., Qi, Lu, Speliotes, Elizabeth K., Fox, Caroline S., Barroso, Inês

Volltext

Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits von Raulerson, Chelsea K., Ko, Arthur, Kidd, John C., Currin, Kevin W., Brotman, Sarah M., Cannon, Maren E., Wu, Ying, Spracklen, Cassandra N., Jackson, Anne U., Stringham, Heather M., Welch, Ryan P., Fuchsberger, Christian, Locke, Adam E., Narisu, Narisu, Lusis, Aldons J., Civelek, Mete, Furey, Terrence S., Kuusisto, Johanna, Collins, Francis S., Boehnke, Michael, Scott, Laura J., Lin, Dan-Yu, Love, Michael I., Laakso, Markku, Pajukanta, Päivi, Mohlke, Karen L.

Volltext

Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial von Sink, Kaycee M, Espeland, Mark A, Castro, Cynthia M, Church, Timothy, Cohen, Ron, Dodson, John A, Guralnik, Jack, Hendrie, Hugh C, Jennings, Janine, Katula, Jeffery, Lopez, Oscar L, McDermott, Mary M, Pahor, Marco, Reid, Kieran F, Rushing, Julia, Verghese, Joe, Rapp, Stephen, Williamson, Jeff D

Volltext

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor von You, Dan, Hillerman, Stephen, Locke, Gregory, Chaudhry, Charu, Stromko, Caitlyn, Murtaza, Anwar, Fan, Yi, Koenitzer, Jennifer, Chen, Yali, Briceno, Stephanie, Bhadra, Rajarshi, Duperret, Elizabeth, Gullo-Brown, Johnni, Gao, Chan, Zhao, Dandan, Feder, John, Curtin, Joshua, Degnan, Andrew P, Kumi, Godwin, Wittman, Mark, Johnson, Benjamin M, Parrish, Karen E, Gokulrangan, Giridharan, Morrison, John, Quigley, Michael, Hunt, John T, Salter-Cid, Luisa, Lees, Emma, Sanjuan, Miguel A, Liu, Jinqi

Volltext

Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis von Garin, Intza, Edghill, Emma L, Akerman, Ildem, Rubio-Cabezas, Oscar, Rica, Itxaso, Locke, Jonathan M, Maestro, Miguel Angel, Alshaikh, Adnan, Bundak, Ruveyde, del Castillo, Gabriel, Deeb, Asma, Deiss, Dorothee, Fernandez, Juan M, Godbole, Koumudi, Hussain, Khalid, O'Connell, Michele, Klupa, Thomasz, Kolouskova, Stanislava, Mohsin, Fauzia, Perlman, Kusiel, Sumnik, Zdenek, Rial, Jose M, Ugarte, Estibaliz, Vasanthi, Thiruvengadam, Johnstone, Karen, Flanagan, Sarah E, Martínez, Rosa, Castaño, Carlos, Patch, Ann-Marie, Fernández-Rebollo, Eduardo, Raile, Klemens, Morgan, Noel, Harries, Lorna W, Castaño, Luis, Ellard, Sian, Ferrer, Jorge, de Nanclares, Guiomar Perez, Hattersley, Andrew T

Volltext