Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors von Lochhead, Pamela A., Tucker, Julie A., Tatum, Natalie J., Wang, Jinhua, Oxley, David, Kidger, Andrew M., Johnson, Victoria P., Cassidy, Megan A., Gray, Nathanael S., Noble, Martin E. M., Cook, Simon J.

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Protein kinase activation loop autophosphorylation in cis: overcoming a Catch-22 situation von Lochhead, Pamela A

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ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? von Cook, Simon J, Lochhead, Pamela A

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Activation-Loop Autophosphorylation Is Mediated by a Novel Transitional Intermediate Form of DYRKs von Lochhead, Pamela A., Sibbet, Gary, Morrice, Nick, Cleghon, Vaughn

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DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome von Najas, Sònia, Arranz, Juan, Lochhead, Pamela A., Ashford, Anne L., Oxley, David, Delabar, Jean M., Cook, Simon J., Barallobre, María José, Arbonés, Maria L.

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Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression von LOCHHEAD, Pamela A, COGHLAN, Matthew, RICE, Simon Q. J, SUTHERLAND, Calum

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Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for von Cook, Simon J, Tucker, Julie A, Lochhead, Pamela A

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A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288) von Ashford, Anne L, Oxley, David, Kettle, Jason, Hudson, Kevin, Guichard, Sylvie, Cook, Simon J, Lochhead, Pamela A

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dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX von Kinstrie, Ross, Lochhead, Pamela A, Sibbet, Gary, Morrice, Nick, Cleghon, Vaughn

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Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation von Lochhead, Pamela A., Clark, Jonathan, Wang, Lan-Zhen, Gilmour, Lesley, Squires, Matthew, Gilley, Rebecca, Foxton, Caroline, Newell, David R., Wedge, Stephen R., Cook, Simon J.

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dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila von Lochhead, Pamela A, Sibbet, Gary, Kinstrie, Ross, Cleghon, Tava, Rylatt, Margie, Morrison, Deborah K, Cleghon, Vaughn

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Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome von Ashford, Anne L, Dunkley, Tom P. J, Cockerill, Mark, Rowlinson, Rachel A, Baak, Lisa M, Gallo, Raffaella, Balmanno, Kathryn, Goodwin, Louise M, Ward, Richard A, Lochhead, Pamela A, Guichard, Sylvie, Hudson, Kevin, Cook, Simon J

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Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4 von Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Tucker, Julie A., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

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5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase von LOCHHEAD, P. A, SALT, I. P, WALKER, K. S, HARDIE, D. G, SUTHERLAND, C

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Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases von Kinstrie, Ross, Luebbering, Nathan, Miranda-Saavedra, Diego, Sibbet, Gary, Han, Jingfen, Lochhead, Pamela A, Cleghon, Vaughn

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Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activit... von Patel, Satish, Lochhead, Pamela A., Rena, Graham, Fumagalli, Stefano, Pende, Mario, Kozma, Sara C., Thomas, George, Sutherland, Calum

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CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL von Gilley, Rebecca, Lochhead, Pamela A., Balmanno, Kathryn, Oxley, David, Clark, Jonathan, Cook, Simon J.

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A Chaperone-Dependent GSK3β Transitional Intermediate Mediates Activation-Loop Autophosphorylation von Lochhead, Pamela A., Kinstrie, Ross, Sibbet, Gary, Rawjee, Teeara, Morrice, Nick, Cleghon, Vaughn

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A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288 von Ashford, Anne L., Oxley, David, Kettle, Jason, Hudson, Kevin, Guichard, Sylvie, Cook, Simon J., Lochhead, Pamela A.

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CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIM sub(EL) von Gilley, Rebecca, Lochhead, Pamela A, Balmanno, Kathryn, Oxley, David, Clark, Jonathan, Cook, Simon J

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