Activation-Loop Autophosphorylation Is Mediated by a Novel Transitional Intermediate Form of DYRKs von Lochhead, Pamela A., Sibbet, Gary, Morrice, Nick, Cleghon, Vaughn

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Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors von Lochhead, Pamela A., Tucker, Julie A., Tatum, Natalie J., Wang, Jinhua, Oxley, David, Kidger, Andrew M., Johnson, Victoria P., Cassidy, Megan A., Gray, Nathanael S., Noble, Martin E. M., Cook, Simon J.

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Protein kinase activation loop autophosphorylation in cis: overcoming a Catch-22 situation von Lochhead, Pamela A

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ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? von Cook, Simon J, Lochhead, Pamela A

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Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas von Ogden, Alfred T, Waziri, Allen E, Lochhead, Richard A, Fusco, David, Lopez, Kim, Ellis, Jason A, Kang, Joann, Assanah, Marcela, McKhann, Guy M, Sisti, Michael B, McCormick, Paul C, Canoll, Peter, Bruce, Jeffrey N

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5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase von LOCHHEAD, P. A, SALT, I. P, WALKER, K. S, HARDIE, D. G, SUTHERLAND, C

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Activating ROCK1 somatic mutations in human cancer von Lochhead, P A, Wickman, G, Mezna, M, Olson, M F

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Circulating microtranscriptome profiles reveal distinct expression of microRNAs in severe leptospirosis von Limothai, Umaporn, Dinhuzen, Janejira, Payongsri, Titipon, Tachaboon, Sasipha, Tangkijvanich, Pisit, Chuaypen, Natthaya, Srisawat, Nattachai

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DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome von Najas, Sònia, Arranz, Juan, Lochhead, Pamela A., Ashford, Anne L., Oxley, David, Delabar, Jean M., Cook, Simon J., Barallobre, María José, Arbonés, Maria L.

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Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for von Cook, Simon J, Tucker, Julie A, Lochhead, Pamela A

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Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression von LOCHHEAD, Pamela A, COGHLAN, Matthew, RICE, Simon Q. J, SUTHERLAND, Calum

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Development of overall survival (OS) and progression free survival (PFS) nomograms for Australian patients with locoregionally advanced oropharyngeal squamous cell carcinoma (LA OP... von Xu, K., Lo, A., Chin, V., Gzell, C., O’Connor, C., Forstner, D., Gallagher, R., Bova, R., Crawford, J., Harvey, R., Lochhead, A., Earls, P., Qiu, M.R., Hsu, E., Bigg-Wither, G., Chan, L., Bao, H., Foltyn, P., Sim, H.-W., Prawira, A.

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Regional brain gray matter volume differences in patients with bipolar disorder as assessed by Optimized voxel-based morphometry von LOCHHEAD, Richard A, PARSEY, Ramin V, OQUENDO, Maria A, MANN, J. John

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A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288) von Ashford, Anne L, Oxley, David, Kettle, Jason, Hudson, Kevin, Guichard, Sylvie, Cook, Simon J, Lochhead, Pamela A

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dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX von Kinstrie, Ross, Lochhead, Pamela A, Sibbet, Gary, Morrice, Nick, Cleghon, Vaughn

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dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila von Lochhead, Pamela A, Sibbet, Gary, Kinstrie, Ross, Cleghon, Tava, Rylatt, Margie, Morrison, Deborah K, Cleghon, Vaughn

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Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus von Bowman, Louise, Mafham, Marion, Wallendszus, Karl, Stevens, Will, Buck, Georgina, Barton, Jill, Murphy, Kevin, Aung, Theingi, Haynes, Richard, Cox, Jolyon, Murawska, Aleksandra, Young, Allen, Lay, Michael, Chen, Fang, Sammons, Emily, Waters, Emma, Adler, Amanda, Bodansky, Jonathan, Farmer, Andrew, McPherson, Roger, Neil, Andrew, Simpson, David, Peto, Richard, Baigent, Colin, Collins, Rory, Parish, Sarah, Armitage, Jane

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Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus von Bowman, Louise, Mafham, Marion, Wallendszus, Karl, Stevens, Will, Buck, Georgina, Barton, Jill, Murphy, Kevin, Aung, Theingi, Haynes, Richard, Cox, Jolyon, Murawska, Aleksandra, Young, Allen, Lay, Michael, Chen, Fang, Sammons, Emily, Waters, Emma, Adler, Amanda, Bodansky, Jonathan, Farmer, Andrew, McPherson, Roger, Neil, Andrew, Simpson, David, Peto, Richard, Baigent, Colin, Collins, Rory, Parish, Sarah, Armitage, Jane

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Long‐term efficacy and complications of a multicentre randomised controlled trial comparing retropubic and transobturator mid‐urethral slings: a prospective observational study von Offiah, I, Freeman, R, Offiah, I, Freeman, R, Waterfield, M, Lochhead, K, Hillard, T, Madhu, C, Sultan, A, James, M, Foley, S, Buckley, S, Speaksman, M, Reid, F, Abrams, P

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Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation von Lochhead, Pamela A., Clark, Jonathan, Wang, Lan-Zhen, Gilmour, Lesley, Squires, Matthew, Gilley, Rebecca, Foxton, Caroline, Newell, David R., Wedge, Stephen R., Cook, Simon J.

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