Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing von Tang, Qin, Iyer, Sowmya, Lobbardi, Riadh, Moore, John C, Chen, Huidong, Lareau, Caleb, Hebert, Christine, Shaw, McKenzie L, Neftel, Cyril, Suva, Mario L, Ceol, Craig J, Bernards, Andre, Aryee, Martin, Pinello, Luca, Drummond, Iain A, Langenau, David M

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Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma von Chen, Eleanor Y., DeRan, Michael T., Ignatius, Myron S., Grandinetti, Kathryn Brooke, Clagg, Ryan, McCarthy, Karin M., Lobbardi, Riadh M., Brockmann, Jillian, Keller, Charles, Wu, Xu, Langenau, David M.

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Identification and characterization of T reg-like cells in zebrafish von Kasheta, Melissa, Painter, Corrie A, Moore, Finola E, Lobbardi, Riadh, Bryll, Alysia, Freiman, Eli, Stachura, David, Rogers, Arlin B, Houvras, Yariv, Langenau, David M, Ceol, Craig J

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Optimized cell transplantation using adult rag2 mutant zebrafish von Tang, Qin, Abdelfattah, Nouran S, Blackburn, Jessica S, Moore, John C, Martinez, Sarah A, Moore, Finola E, Lobbardi, Riadh, Tenente, Inês M, Ignatius, Myron S, Berman, Jason N, Liwski, Robert S, Houvras, Yariv, Langenau, David M

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The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma von Ignatius, Myron S., Hayes, Madeline N., Lobbardi, Riadh, Chen, Eleanor Y., McCarthy, Karin M., Sreenivas, Prethish, Motala, Zainab, Durbin, Adam D., Molodtsov, Aleksey, Reeder, Sophia, Jin, Alexander, Sindiri, Sivasish, Beleyea, Brian C., Bhere, Deepak, Alexander, Matthew S., Shah, Khalid, Keller, Charles, Linardic, Corinne M., Nielsen, Petur G., Malkin, David, Khan, Javed, Langenau, David M.

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JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia von Mansour, Marc R, He, Shuning, Li, Zhaodong, Lobbardi, Riadh, Abraham, Brian J, Hug, Clemens, Rahman, Sunniyat, Leon, Theresa E, Kuang, You-Yi, Zimmerman, Mark W, Blonquist, Traci, Gjini, Evisa, Gutierrez, Alejandro, Tang, Qin, Garcia-Perez, Laura, Pike-Overzet, Karin, Anders, Lars, Berezovskaya, Alla, Zhou, Yi, Zon, Leonard I, Neuberg, Donna, Fielding, Adele K, Staal, Frank J T, Langenau, David M, Sanda, Takaomi, Young, Richard A, Look, A Thomas

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Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma von Schalm, Stefanie S., O’Hearn, Erin, Wilson, Kevin, LaBranche, Timothy P., Silva, Grace, Zhang, Zhuo, DiPietro, Lucian, Bifulco, Neil, Woessner, Richard, Stransky, Nicolas, Sappal, Darshan, Campbell, Robert, Lobbardi, Riadh, Palmer, Michael, Kim, Joseph, Ye, Chaoyang, Dorsch, Marion, Lengauer, Christoph, Guzi, Timothy, Kadambi, Vivek, Garner, Andrew, Hoeflich, Klaus P.

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CFT8634, a Clinical Stage BRD9 Bi DAC™ Degrader, Is Active in a Subset of Multiple Myeloma Cell Line Models and Synergistic When Combined with Pomalidomide von Poling, Laura L, Cocozziello, David, He, Minsheng, Hurh, Eunju, Lobbardi, Riadh, Jackson, Katrina L, Fisher, Stewart L, Pollock, Roy M

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A phase 1/2 study of CFT1946, a novel, bifunctional degradation activating compound (BIDAC) degrader, of mutant BRAF V600 as monotherapy and in combination with trametinib, in muta... von McKean, Meredith, Spira, Alexander I., Rosen, Ezra, Subbiah, Vivek, Moreno, Victor, Gambardella, Valentina, Vieito, Maria, Saavedra, Omar, Cousin, Sophie, Cassier, Philippe Alexandre, Lobbardi, Riadh, Schönborn-Kellenberger, Oliver, Hurh, Eunju, Ruisi, Mary M., Buchbinder, Elizabeth Iannotti

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CFT7455, a Novel IKZF1/3 Degrader, Demonstrates Potent Anti-Tumor Activity in Models of Non-Hodgkin's Lymphoma As a Single Agent or in Combination with Clinically Approved Agents von Perino, Samantha, Kirby, R. Jason, Agafonov, Roman, Chaturvedi, Prasoon, Eron, Scott, Good, Andrew, Hart, Ashley, He, Minsheng, Lobbardi, Riadh, Phillips, Andrew J, Proia, David, Henderson, James, Thomeius, Michael, Nasveschuk, Christopher, Fisher, Stewart L, Pollock, Roy Macfarlane

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Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish von Moore, John C, Tang, Qin, Yordán, Nora Torres, Moore, Finola E, Garcia, Elaine G, Lobbardi, Riadh, Ramakrishnan, Ashwin, Marvin, Dieuwke L, Anselmo, Anthony, Sadreyev, Ruslan I, Langenau, David M

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Quaking RNA-Binding Proteins Control Early Myofibril Formation by Modulating Tropomyosin von Bonnet, Aline, Lambert, Guillaume, Ernest, Sylvain, Dutrieux, François Xavier, Coulpier, Fanny, Lemoine, Sophie, Lobbardi, Riadh, Rosa, Frédéric Marc

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Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation von Blackburn, Jessica S., Liu, Sali, Wilder, Jayme L., Dobrinski, Kimberly P., Lobbardi, Riadh, Moore, Finola E., Martinez, Sarah A., Chen, Eleanor Y., Lee, Charles, Langenau, David M.

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Abstract A16: The tyrosine phosphatase PRL3 as a novel drug target in T-cell acute lymphoblastic leukemia von Blackburn, Jessica, Molodtsov, Aleksey, Lobbardi, Riadh, Moore, Finola, Langenau, David

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Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish von Moore, Finola E, Garcia, Elaine G, Lobbardi, Riadh, Jain, Esha, Tang, Qin, Moore, John C, Cortes, Mauricio, Molodtsov, Aleksey, Kasheta, Melissa, Luo, Christina C, Garcia, Amaris J, Mylvaganam, Ravi, Yoder, Jeffrey A, Blackburn, Jessica S, Sadreyev, Ruslan I, Ceol, Craig J, North, Trista E, Langenau, David M

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TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia von Lobbardi, Riadh, Pinder, Jordan, Martinez-Pastor, Barbara, Theodorou, Marina, Blackburn, Jessica S, Abraham, Brian J, Namiki, Yuka, Mansour, Marc, Abdelfattah, Nouran S, Molodtsov, Aleksey, Alexe, Gabriela, Toiber, Debra, de Waard, Manon, Jain, Esha, Boukhali, Myriam, Lion, Mattia, Bhere, Deepak, Shah, Khalid, Gutierrez, Alejandro, Stegmaier, Kimberly, Silverman, Lewis B, Sadreyev, Ruslan I, Asara, John M, Oettinger, Marjorie A, Haas, Wilhelm, Look, A Thomas, Young, Richard A, Mostoslavsky, Raul, Dellaire, Graham, Langenau, David M

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Abstract 1279: Development of a selective CDK2-E inhibitor in CCNE driven cancers von Choi, Yoon J., Wenglowsky, Steve, Brown, Victoria, Bifulco, Neil, Choi, Yeon S., Guo, Jian, Hatlen, Megan, Kim, Joseph, LaBranche, Tim, Lobbardi, Riadh, Perola, Emanuele, Rozsahegyi, Emily, Maynard, Michelle, Ramsden, Phil, Silva, Grace, Stevison, Faith, Vargas, Richard, Wang, Ruduan, Wilson, Doug, Woessner, Rich, Zhang, Dean, Meissner, Rob, Hoeflich, Klaus, Dorsch, Marion

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T Cell Immune Deficiency in zap70 Mutant Zebrafish von Moore, John C., Mulligan, Timothy S., Yordán, Nora Torres, Castranova, Daniel, Pham, Van N., Tang, Qin, Lobbardi, Riadh, Anselmo, Anthony, Liwski, Robert S., Berman, Jason N., Sadreyev, Ruslan I., Weinstein, Brant M., Langenau, David M.

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Abstract A33: Role for the tumor suppressor phf6 in hematopoiesis von Moore, Finola E., Esain, Virginie, Lobbardi, Riadh, Blackburn, Jessica S., North, Trista E., Langenau, David M.

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Abstract 1725: The tyrosine phosphatase PRL3 as a novel drug target in T-cell acute lymphoblastic leukemia von Blackburn, Jessica S., Molodstov, Aleksey, Lobbardi, Riadh, Moore, Finola, Langeau, David

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