Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies von Hägerbrand, Karin, Varas, Laura, Deronic, Adnan, Nyesiga, Barnabas, Sundstedt, Anette, Ljung, Lill, Sakellariou, Christina, Werchau, Doreen, Thagesson, Mia, Gomez Jimenez, David, Greiff, Lennart, Celander, Mona, Smedenfors, Kristine, Rosén, Anna, Bölükbas, Deniz, Carlsson, Fredrika, Levin, Mattias, Säll, Anna, von Schantz, Laura, Lindstedt, Malin, Ellmark, Peter

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837 Combination treatment with ATOR-4066, a Neo-X-Prime™ bispecific antibody targeting CD40 and CEACAM5, and anti-PD-1 reverses T cell exhaustion in vitro von Uddbäck, Ida, Fritzell, Sara, Ljung, Lill, Nilsson, Anneli, Celander, Mona, Shetty, Amulya Krishna, Andersson, Hampus, Jimenez, David Gomez, Levin, Mattias, Lindstedt, Malin, Hägerbrand, Karin, Sundstedt, Anette, Ellmark, Peter

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751 Neo-X-Prime bispecific antibodies targeting CD40 and tumor antigens promote cross-presentation of tumor exosome-derived neoantigen and induce superior anti-tumor responses comp... von Hagerbrand, Karin, Levin, Mattias, Schantz, Laura Von, Varas, Laura, Säll, Anna, Deronic, Adnan, Sundstedt, Anette, Ljung, Lill, Barchan, Karin, Werchau, Doreen, Rosén, Anna, Nyesiga, Barnabas, Lindqvist, Eva, Thagesson, Mia, Ellmark, Peter

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796 ALG.APV-527: a 5T4 tumor directed bispecific approach utilizing ADAPTIRTM technology designed for conditional 4-1BB T cell/NK agonism against solid tumors von Nelson, Michelle, Sundstedt, Anette, Coaña, Yago Pico de, Lucas, Ashly, Nilsson, Anneli, Ljung, Lill, Chunyk, Allison, Schultz, Lena, McMahan, Catherine, Gross, Jane, Frizell, Sara, Ramos, Hilario, Ellmark, Peter

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851 Potent tumor-directed T cell activation and in vivo tumor inhibition induced by a 4–1BB x 5T4 ADAPTIR™ bispecific antibody von Nelson, Michelle, Miller, Robert, Nilsson, Anneli, Ljung, Lill, Chunyk, Allison, McMahan, Catherine, Bienvenue, David, Askmyr, Maria, Hernandez-Hoyos, Gabriela, Fritzell, Sara

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The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies von Nelson, Michelle H, Fritzell, Sara, Miller, Robert, Werchau, Doreen, Van Citters, Danielle, Nilsson, Anneli, Misher, Lynda, Ljung, Lill, Bader, Robert, Deronic, Adnan, Chunyk, Allison G, Schultz, Lena, Varas, Laura A, Rose, Nadia, Håkansson, Maria, Gross, Jane, Furebring, Christina, Pavlik, Peter, Sundstedt, Anette, Veitonmäki, Niina, Ramos, Hilario J, Säll, Anna, Dahlman, Anna, Bienvenue, David, von Schantz, Laura, McMahan, Catherine J, Askmyr, Maria, Hernandez-Hoyos, Gabriela, Ellmark, Peter

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Abstract 2380: Preclinical safety and efficacy of a tumor-directed T cell activating 4-1BB x 5T4 ADAPTIR™ bispecific antibody von Dahlman, Anna, Nelson, Michelle, Bannink, Jeannette, Johnson, Starrla, Werchau, Doreen, Nilsson, Anneli, Ljung, Lill, Blahnik-Fagan, Gabriele, Bader, Robert, Deronic, Adnan, Ellmark, Peter, Askmyr, Maria, Hernandez-Hoyos, Gabriela, McMahan, Cathy, Fritzell, Sara

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Abstract 2939: ATOR-4066, a Neo-X-Prime bispecific antibody targeting CD40 and CEA, activates myeloid cells in primary human tumors in vitro and induces anti-tumor immunity in vivo von Hägerbrand, Karin, Sundstedt, Anette, Levin, Mattias, de Coaña, Yago Pico, Varas, Laura, Ljung, Lill, Nilsson, Anneli, Celander, Mona, Jimenez, David Gomez, Andersson, Hampus, Lindstedt, Malin, Ellmark, Peter

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Purification of truncated and mutated Chemotaxis Inhibitory Protein of Staphylococcus aureus—an anti-inflammatory protein von Gustafsson, Erika, Forsberg, Cecilia, Haraldsson, Karin, Lindman, Stina, Ljung, Lill, Furebring, Christina

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Directed evolution of chemotaxis inhibitory protein of Staphylococcus aureus generates biologically functional variants with reduced interaction with human antibodies von Gustafsson, Erika, Rosén, Anna, Barchan, Karin, van Kessel, Kok P.M., Haraldsson, Karin, Lindman, Stina, Forsberg, Cecilia, Ljung, Lill, Bryder, Karin, Walse, Björn, Haas, Pieter-Jan, van Strijp, Jos A.G., Furebring, Christina

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Development of Interleukin-1 Receptor Antagonist Mutants with Enhanced Antagonistic Activity In Vitro and Improved Therapeutic Efficacy in Collagen-Induced Arthritis von Dahlén, Eva, Barchan, Karin, Herrlander, Daniel, Höjman, Patrik, Karlsson, Marie, Ljung, Lill, Andersson, Mats, Bäckman, Eva, Hager, Ann-Christin Malmborg, Walse, Björn, Joosten, Leo, van den Berg, Wim

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Targeting CD38 with monoclonal antibodies disrupts key survival pathways in paediatric Burkitt's lymphoma malignant B cells von Kläsener, Kathrin, Herrmann, Nadja, Håversen, Liliana, Sundell, Timothy, Sundqvist, Martina, Lundqvist, Christina, Manna, Paul T, Jonsson, Charlotte A, Visentini, Marcella, Ljung Sass, Diana, McGrath, Sarah, Grimstad, Kristoffer, Aranburu, Alaitz, Mellgren, Karin, Fogelstrand, Linda, Forsman, Huamei, Ekwall, Olov, Borén, Jan, Gjertsson, Inger, Reth, Michael, Mårtensson, Inga-Lill, Camponeschi, Alessandro

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