Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer von Yu, Le, Wei, Jessica, Liu, Pengda

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Cytosolic DNA sensing by cGAS: regulation, function, and human diseases von Yu, Le, Liu, Pengda

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AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions von Guo, Jianping, Dai, Xiangpeng, Laurent, Benoit, Zheng, Nana, Gan, Wenjian, Zhang, Jian, Guo, Ailan, Yuan, Min, Liu, Pengda, Asara, John M., Toker, Alex, Shi, Yang, Pandolfi, Pier Paolo, Wei, Wenyi

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Structural basis of nucleosome-dependent cGAS inhibition von Boyer, Joshua A, Spangler, Cathy J, Strauss, Joshua D, Cesmat, Andrew P, Liu, Pengda, McGinty, Robert K, Zhang, Qi

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Control of mTOR signaling by ubiquitin von Jiang, Yao, Su, Siyuan, Zhang, Yanqiong, Qian, Jiayi, Liu, Pengda

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K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair von Liu, Pengda, Gan, Wenjian, Su, Siyuan, Hauenstein, Arthur V, Fu, Tian-Min, Brasher, Bradley, Schwerdtfeger, Carsten, Liang, Anthony C, Xu, Ming, Wei, Wenyi

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex von Liu, Pengda, Gan, Wenjian, Chin, Y Rebecca, Ogura, Kohei, Guo, Jianping, Zhang, Jinfang, Wang, Bin, Blenis, John, Cantley, Lewis C, Toker, Alex, Su, Bing, Wei, Wenyi

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Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 von Dai, Xiangpeng, Gan, Wenjian, Li, Xiaoning, Wang, Shangqian, Zhang, Wei, Huang, Ling, Liu, Shengwu, Zhong, Qing, Guo, Jianping, Zhang, Jinfang, Chen, Ting, Shimizu, Kouhei, Beca, Francisco, Blattner, Mirjam, Vasudevan, Divya, Buckley, Dennis L, Qi, Jun, Buser, Lorenz, Liu, Pengda, Inuzuka, Hiroyuki, Beck, Andrew H, Wang, Liewei, Wild, Peter J, Garraway, Levi A, Rubin, Mark A, Barbieri, Christopher E, Wong, Kwok-Kin, Muthuswamy, Senthil K, Huang, Jiaoti, Chen, Yu, Bradner, James E, Wei, Wenyi

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LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control von Gan, Wenjian, Dai, Xiaoming, Dai, Xiangpeng, Xie, Jun, Yin, Shasha, Zhu, Junjie, Wang, Chen, Liu, Yuchen, Guo, Jianping, Wang, Min, Liu, Jing, Hu, Jia, Quinton, Ryan J., Ganem, Neil J., Liu, Pengda, Asara, John M., Pandolfi, Pier Paolo, Yang, Yingzi, He, Zhigang, Gao, Guangping, Wei, Wenyi

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Characteristics of and variation in airborne ARGs among urban hospitals and adjacent urban and suburban communities: A metagenomic approach von He, Peng, Wu, Yan, Huang, Wenzhong, Wu, Xinwei, Lv, Jiayun, Liu, Pengda, Bu, Li, Bai, Zhijun, Chen, Shouyi, Feng, Wenru, Yang, Zhicong

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SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression von Gan, Wenjian, Dai, Xiangpeng, Lunardi, Andrea, Li, Zhen, Inuzuka, Hiroyuki, Liu, Pengda, Varmeh, Shoreh, Zhang, Jinfang, Cheng, Liang, Sun, Yin, Asara, John M., Beck, Andrew H., Huang, Jiaoti, Pandolfi, Pier Paolo, Wei, Wenyi

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BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail von Qin, Zhong-Yi, Wang, Tao, Su, Siyuan, Shen, Li-Ting, Zhu, Guang-Xi, Liu, Qin, Zhang, Liang, Liu, Ke-Wei, Zhang, Yue, Zhou, Zhi-Hua, Zhang, Xiao-Ning, Wen, Liang-Zhi, Yao, Yue-Liang, Sun, Wen-Jing, Guo, Yan, Liu, Kai-Jun, Liu, Lei, Wang, Xing-Wei, Wei, Yan-Ling, Wang, Jun, Xiao, Hua-Liang, Liu, Pengda, Bian, Xiu-Wu, Chen, Dong-Feng, Wang, Bin

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Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy von Kim, Byeong Mo, Hong, Yunkyung, Lee, Seunghoon, Liu, Pengda, Lim, Ji Hong, Lee, Yong Heon, Lee, Tae Ho, Chang, Kyu Tae, Hong, Yonggeun

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DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway von Liu, Liu, Dai, Xiaoming, Yin, Shasha, Liu, Pengda, Hill, Elizabeth G, Wei, Wenyi, Gan, Wenjian

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MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression von Jiang, Yao, Zhang, Yanqiong, Leung, Janet Y., Fan, Cheng, Popov, Konstantin I., Su, Siyuan, Qian, Jiayi, Wang, Xiaodong, Holtzhausen, Alisha, Ubil, Eric, Xiang, Yang, Davis, Ian, Dokholyan, Nikolay V., Wu, Gang, Perou, Charles M., Kim, William Y., Earp, H. Shelton, Liu, Pengda

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pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner von Guo, Jianping, Chakraborty, Abhishek A., Liu, Pengda, Gan, Wenjian, Zheng, Xingnan, Inuzuka, Hiroyuki, Wang, Bin, Zhang, Jinfang, Zhang, Linli, Yuan, Min, Novak, Jesse, Cheng, Jin Q., Toker, Alex, Signoretti, Sabina, Zhang, Qing, Asara, John M., Kaelin, William G., Wei, Wenyi

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Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma von Yu, Le, Deng, Yu, Wang, Xiaodong, Santos, Charlene, Davis, Ian J., Earp, H. Shelton, Liu, Pengda

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CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1 von Bartkowiak, Bartlomiej, Liu, Pengda, Phatnani, Hemali P, Fuda, Nicholas J, Cooper, Jeffrey J, Price, David H, Adelman, Karen, Lis, John T, Greenleaf, Arno L

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Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus von Liu, Pengda, Begley, Michael, Michowski, Wojciech, Inuzuka, Hiroyuki, Ginzberg, Miriam, Gao, Daming, Tsou, Peiling, Gan, Wenjian, Papa, Antonella, Kim, Byeong Mo, Wan, Lixin, Singh, Amrik, Zhai, Bo, Yuan, Min, Wang, Zhiwei, Gygi, Steven P., Lee, Tae Ho, Lu, Kun-Ping, Toker, Alex, Pandolfi, Pier Paolo, Asara, John M., Kirschner, Marc W., Sicinski, Piotr, Cantley, Lewis, Wei, Wenyi

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Phosphorylation of Akt at the C-terminal tail triggers Akt Activation von Liu, Pengda, Wang, Zhiwei, Wei, Wenyi

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