Macrocyclic biphenyl tetraoxazoles: Synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity von Blankson, Gifty A., Pilch, Daniel S., Liu, Angela A., Liu, Leroy F., Rice, Joseph E., LaVoie, Edmond J.

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Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell Death von Daroui, Parima, Desai, Shyamal D., Li, Tsai-Kun, Liu, Angela A., Liu, Leroy F.

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Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity von Satyanarayana, Mavurapu, Kim, Young-Ah, Rzuczek, Suzanne G., Pilch, Daniel S., Liu, Angela A., Liu, Leroy F., Rice, Joseph E., LaVoie, Edmond J.

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G-quadruplexes induce apoptosis in tumor cells von HAIYAN QI, LIN, Chao-Po, XUAN FU, WOOD, Laurence M, LIU, Angela A, TSAI, Yuan-Chin, YONGJIE CHEN, BARBIERI, Christopher M, PITCH, Daniel S, LIU, Leroy F

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Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug von LI, Tsai-Kun, HOUGHTON, Peter J, DESAI, Shyamal D, DAROUI, Parima, LIU, Angela A, HARS, Eszter S, RUCHELMAN, Alexander L, LAVOIE, Edmond J, LIU, Leroy F

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Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[ i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents von Zhu, Shejin, Ruchelman, Alexander L., Zhou, Nai, Liu, Angela A., Liu, Leroy F., LaVoie, Edmond J.

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Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammoni... von WEI FENG, SATYANARAYANA, Mavurapu, TSAI, Yuan-Chin, LIU, Angela A, LIU, Leroy F, LAVOIE, Edmond J

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12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[ i]phenanthridines as novel topoisomerase I-targeting antitumor agents von Feng, Wei, Satyanarayana, Mavurapu, Tsai, Yuan-Chin, Liu, Angela A., Liu, Leroy F., LaVoie, Edmond J.

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Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones von Sharma, Lisa, Tsai, Yuan-Chin, Liu, Angela A, Liu, Leroy F, LaVoie, Edmond J

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Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11 -[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-... von SATYANARAYANA, Mavurapu, WEI FENG, LIANG CHENG, LIU, Angela A, TSAI, Yuan-Chin, LIU, Leroy F, LAVOIE, Edmond J

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Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analo... von Feng, Wei, Satyanarayana, Mavurapu, Tsai, Yuan-Chin, Liu, Angela A, Liu, Leroy F, Lavoie, Edmond J

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11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[ i]phenanthridine derivatives as novel topoisomerase I-targeting agents von Feng, Wei, Satyanarayana, Mavurapu, Tsai, Yuan-Chin, Liu, Angela A., Liu, Leroy F., LaVoie, Edmond J.

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Mutations of Human Topoisomerase IIα Affecting Multidrug Resistance and Sensitivity von Mao, Yong, Yu, Chiang, Hsieh, Tao-Shih, Nitiss, John L, Liu, Angela A, Wang, Huimin, Liu, Leroy F

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Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury von Usachov, Valentyn, Urban, Thomas J, Fontana, Robert J, Gross, Annika, Iyer, Sapna, Omary, M Bishr, Strnad, Pavel

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Differential Poisoning of Topoisomerases by Menogaril and Nogalamycin Dictated by the Minor Groove-Binding Nogalose Sugar von Sim, Sai-Peng, Gatto, Barbara, Yu, Chiang, Liu, Angela A, Li, Tsai-Kun, Pilch, Daniel S, LaVoie, Edmond J, Liu, Leroy F

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Novel topoisomerase I-targeting antitumor agents synthesized from the N, N, N-trimethylammonium derivative of ARC-111, 5 H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2- N, N, N-trimethyl... von Feng, Wei, Satyanarayana, Mavurapu, Tsai, Yuan-Chin, Liu, Angela A., Liu, Leroy F., LaVoie, Edmond J.

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Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2- N, N-dimethylamino)ethyl-5 H-dibenzo[ c, h][1,6]naphthyridin-6-ones von Sharma, Lisa, Tsai, Yuan-Chin, Liu, Angela A., Liu, Leroy F., LaVoie, Edmond J.

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Cytotoxicity and TOPI-targeting activity of 8-and 9-amino derivatives of 5-butyl-and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones von SHARMA, Lisa, TSAI, Yuan-Chin, LIU, Angela A, LIU, Leroy F, LAVOIE, Edmond J

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Facile formation of hydrophilic derivatives of 5 H-8,9-dimethoxy-5-[2-( N, N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[ c, h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza... von Feng, Wei, Satyanarayana, Mavurapu, Tsai, Yuan-chin, Liu, Angela A., Liu, Leroy F., LaVoie, Edmond J.

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Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylene-dioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza anal... von WEI FENG, SATYANARAYANA, Mavurapu, TSAI, Yuan-Chin, LIU, Angela A, LIU, Leroy F, LAVOIE, Edmond J

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