p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway von Duran, Angeles, Amanchy, Ramars, Linares, Juan F., Joshi, Jayashree, Abu-Baker, Shadi, Porollo, Aleksey, Hansen, Malene, Moscat, Jorge, Diaz-Meco, Maria T.

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K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells von Linares, Juan F., Duran, Angeles, Yajima, Tomoko, Pasparakis, Manolis, Moscat, Jorge, Diaz-Meco, Maria T.

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p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells von Umemura, Atsushi, He, Feng, Taniguchi, Koji, Nakagawa, Hayato, Yamachika, Shinichiro, Font-Burgada, Joan, Zhong, Zhenyu, Subramaniam, Shankar, Raghunandan, Sindhu, Duran, Angeles, Linares, Juan F., Reina-Campos, Miguel, Umemura, Shiori, Valasek, Mark A., Seki, Ekihiro, Yamaguchi, Kanji, Koike, Kazuhiko, Itoh, Yoshito, Diaz-Meco, Maria T., Moscat, Jorge, Karin, Michael

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Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population von Kasashima, Hiroaki, Duran, Angeles, Martinez-Ordoñez, Anxo, Nakanishi, Yuki, Kinoshita, Hiroto, Linares, Juan F., Reina-Campos, Miguel, Kudo, Yotaro, L’Hermitte, Antoine, Yashiro, Masakazu, Ohira, Masaichi, Bao, Fei, Tauriello, Daniele V.F., Batlle, Eduard, Diaz-Meco, Maria T., Moscat, Jorge

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Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade von Linares, Juan F., Duran, Angeles, Reina-Campos, Miguel, Aza-Blanc, Pedro, Campos, Alex, Moscat, Jorge, Diaz-Meco, Maria T.

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ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma von Linares, Juan F., Cordes, Thekla, Duran, Angeles, Reina-Campos, Miguel, Valencia, Tania, Ahn, Christopher S., Castilla, Elias A., Moscat, Jorge, Metallo, Christian M., Diaz-Meco, Maria T.

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ZZ-dependent regulation of p62/SQSTM1 in autophagy von Zhang, Yi, Mun, Su Ran, Linares, Juan F., Ahn, JaeWoo, Towers, Christina G., Ji, Chang Hoon, Fitzwalter, Brent E., Holden, Michael R., Mi, Wenyi, Shi, Xiaobing, Moscat, Jorge, Thorburn, Andrew, Diaz-Meco, Maria T., Kwon, Yong Tae, Kutateladze, Tatiana G.

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Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ von Llado, Victoria, Nakanishi, Yuki, Duran, Angeles, Reina-Campos, Miguel, Shelton, Phillip M., Linares, Juan F., Yajima, Tomoko, Campos, Alex, Aza-Blanc, Pedro, Leitges, Michael, Diaz-Meco, Maria T., Moscat, Jorge

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NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ von Huang, Jianfeng, Linares, Juan F., Duran, Angeles, Xia, Wenmin, Saltiel, Alan R., Müller, Timo D., Diaz-Meco, Maria T., Moscat, Jorge

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Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer von Chatterjee, Shankha S., Linares, Juan F., Cid-Diaz, Tania, Duran, Angeles, Khan, Mohd. Imran K., Osrodek, Marta, Brady, Nicholas J., Reina-Campos, Miguel, Marzio, Antonio, Venkadakrishnan, Varadha Balaji, Bakht, Martin K., Khani, Francesca, Mosquera, Juan Miguel, Robinson, Brian D., Moyer, Jenna, Elemento, Olivier, Hsieh, Andrew C., Goodrich, David W., Rickman, David S., Beltran, Himisha, Moscat, Jorge, Diaz-Meco, Maria T.

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Virulence and Metabolism Crosstalk: Impaired Activity of the Type Three Secretion System (T3SS) in a Pseudomonas aeruginosa Crc-Defective Mutant von Gil-Gil, Teresa, Cuesta, Trinidad, Hernando-Amado, Sara, Reales-Calderón, Jose Antonio, Corona, Fernando, Linares, Juan F, Martínez, José L

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Overexpression of the Multidrug Efflux Pumps MexCD-OprJ and MexEF-OprN Is Associated with a Reduction of Type III Secretion in Pseudomonas aeruginosa von LINARES, Juan F, LOPEZ, Juan A, CAMAFEITA, Emilio, ALBAR, Juan P, ROJO, Fernando, MARTINEZ, Jose L

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Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis von Muta, Yu, Linares, Juan F., Martinez-Ordoñez, Anxo, Duran, Angeles, Cid-Diaz, Tania, Kinoshita, Hiroto, Zhang, Xiao, Han, Qixiu, Nakanishi, Yuki, Nakanishi, Naoko, Cordes, Thekla, Arora, Gurpreet K., Ruiz-Martinez, Marc, Reina-Campos, Miguel, Kasashima, Hiroaki, Yashiro, Masakazu, Maeda, Kiyoshi, Albaladejo-Gonzalez, Ana, Torres-Moreno, Daniel, García-Solano, José, Conesa-Zamora, Pablo, Inghirami, Giorgio, Metallo, Christian M., Osborne, Timothy F., Diaz-Meco, Maria T., Moscat, Jorge

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A Macrophage NBR1-MEKK3 Complex Triggers JNK-Mediated Adipose Tissue Inflammation in Obesity von Hernandez, Eloy D., Lee, Sang Jun, Kim, Ji Young, Duran, Angeles, Linares, Juan F., Yajima, Tomoko, Müller, Timo D., Tschöp, Matthias H., Smith, Steven R., Diaz-Meco, Maria T., Moscat, Jorge

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Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation von Linares, Juan F., Amanchy, Ramars, Diaz-Meco, Maria T., Moscat, Jorge

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PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression von Kudo, Yotaro, Sugimoto, Masayuki, Arias, Esperanza, Kasashima, Hiroaki, Cordes, Thekla, Linares, Juan F., Duran, Angeles, Nakanishi, Yuki, Nakanishi, Naoko, L'Hermitte, Antoine, Campos, Alex, Senni, Nadia, Rooslid, Tarmo, Roberts, Lewis R., Cuervo, Ana Maria, Metallo, Christian M., Karin, Michael, Diaz-Meco, Maria T., Moscat, Jorge

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Protein kinase Cλ/ι in cancer: a contextual balance of time and signals von Moscat, Jorge, Linares, Juan F., Duran, Angeles, Diaz-Meco, Maria T.

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Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer von Reina-Campos, Miguel, Linares, Juan F., Duran, Angeles, Cordes, Thekla, L'Hermitte, Antoine, Badur, Mehmet G., Bhangoo, Munveer S., Thorson, Phataraporn K., Richards, Alicia, Rooslid, Tarmo, Garcia-Olmo, Dolores C., Nam-Cha, Syongh Y., Salinas-Sanchez, Antonio S., Eng, Ken, Beltran, Himisha, Scott, David A., Metallo, Christian M., Moscat, Jorge, Diaz-Meco, Maria T.

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Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis von Joshi, Jayashree, Fernandez-Marcos, Pablo J, Galvez, Anita, Amanchy, Ramars, Linares, Juan F, Duran, Angeles, Pathrose, Peterson, Leitges, Michael, Cañamero, Marta, Collado, Manuel, Salas, Clara, Serrano, Manuel, Moscat, Jorge, Diaz-Meco, Maria T

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Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer von Martinez-Ordoñez, Anxo, Duran, Angeles, Ruiz-Martinez, Marc, Cid-Diaz, Tania, Zhang, Xiao, Han, Qixiu, Kinoshita, Hiroto, Muta, Yu, Linares, Juan F., Kasashima, Hiroaki, Nakanishi, Yuki, Omar, Mohamed, Nishimura, Sadaaki, Avila, Leandro, Yashiro, Masakazu, Maeda, Kiyoshi, Pannellini, Tania, Pigazzi, Alessio, Inghirami, Giorgio, Marchionni, Luigi, Sigal, Darren, Diaz-Meco, Maria T., Moscat, Jorge

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