Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’ von Levin, Aron M., Bates, Darren L., Ring, Aaron M., Krieg, Carsten, Lin, Jack T., Su, Leon, Moraga, Ignacio, Raeber, Miro E., Bowman, Gregory R., Novick, Paul, Pande, Vijay S., Fathman, C. Garrison, Boyman, Onur, Garcia, K. Christopher

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How GRAIL controls Treg function to maintain self-tolerance von Fathman, C Garrison, Yip, Linda, Gómez-Martín, Diana, Yu, Mang, Seroogy, Christine M, Hurt, Clarence R, Lin, Jack T, Jenks, Jennifer A, Nadeau, Kari C, Soares, Luis

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Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion von Houot, Roch, Goldstein, Matthew J., Kohrt, Holbrook E., Myklebust, June H., Alizadeh, Ash A., Lin, Jack T., Irish, Jonathan M., Torchia, James A., Kolstad, Arne, Chen, Lieping, Levy, Ronald

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Activation of the Anticancer Prodrugs Cyclophosphamide and Ifosfamide: Identification of Cytochrome P450 2B Enzymes and Site-Specific Mutants with Improved Enzyme Kinetics von Chen, Chong-Sheng, Lin, Jack T, Goss, Kendrick A, He, You-ai, Halpert, James R, Waxman, David J

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Multi-omic profiling reveals early immunological indicators for identifying COVID-19 Progressors von Drake, Katherine A., Talantov, Dimitri, Tong, Gary J., Lin, Jack T., Verheijden, Simon, Katz, Samuel, Leung, Jacqueline M., Yuen, Benjamin, Krishna, Vinod, Wu, Michelle J., Sutherland, Alexander M., Short, Sarah A., Kheradpour, Pouya, Mumbach, Maxwell R., Franz, Kate M., Trifonov, Vladimir, Lucas, Molly V., Merson, James, Kim, Charles C., Chen, Chen, Parthasarathy, Sairam, Tapson, Victor F., Moy, James N., de Filippi, Christopher R., Rosas, Ivan O., Basit, Mujeeb, Salvatore, Mirella, Krishnan, Jerry A.

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GRAIL: a unique mediator of CD4 T‐lymphocyte unresponsiveness von Whiting, Chan C, Su, Leon L, Lin, Jack T, Garrison Fathman, C

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The Transmembrane E3 Ligase GRAIL Ubiquitinates and Degrades CD83 on CD4 T Cells von Su, Leon L, Iwai, Hideyuki, Lin, Jack T, Fathman, C. Garrison

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Adoptive Cell Therapy for Lymphoma with CD4 T Cells Depleted of CD137-Expressing Regulatory T Cells von GOLDSTEIN, Matthew J, KOHRT, Holbrook E, HOUOT, Roch, VARGHESE, Bindu, LIN, Jack T, SWANSON, Erica, LEVY, Ronald

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Cutting Edge: The Transmembrane E3 Ligase GRAIL Ubiquitinates the Costimulatory Molecule CD40 Ligand during the Induction of T Cell Anergy von Lineberry, Neil B, Su, Leon L, Lin, Jack T, Coffey, Greg P, Seroogy, Christine M, Fathman, C. Garrison

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Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapamycin Regulation of GRAIL Expression von Lin, Jack T, Lineberry, Neil B, Kattah, Michael G, Su, Leon L, Utz, Paul J, Fathman, C. Garrison, Wu, Linda

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Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis von Lin, Jack T, Stein, Emily A, Wong, Michael T, Kalpathy, Krishna J, Su, Leon L, Utz, Paul J, Robinson, William H, Fathman, C. Garrison

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CD28 co-stimulation regulates the effect of transforming growth factor-β1 on the proliferation of naive CD4+ T cells von SUNG, James L, LIN, Jack T, GORHAM, James D

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MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury von Lin, Jack T, Kitzmiller, Tamar J, Cates, Justin M M, Gorham, James D

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TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet von Lin, Jack T., Martin, Stacey L., Xia, Luxi, Gorham, James D.

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Abstract 4246: SENTI-101, a novel genetically modified allogeneic cell product expressing IL12 and IL21, elicits a tumor-localized, robust, and multimodal immune response in precli... von Gonzalez, Alba, Liu, Frances D., Nagaraja, Archana, Mullenix, Alyssa, Gordley, Russell M., Frimannsson, Daniel O., Benabbas, Anissa, Lee, Chen-Ting, Truong, Tiffany A., Quach, Allison, Tian, Mengxi, Martinez, Rowena, Savur, Rishi, Perry-McNamara, Alyssa, Wang, Don-Hong, Maller, Ori, Iyer, Dharini, Magal, Ashita, Mangalampalli, Sravani, Huynh, Christina J., Blanco, Carmina C., Lin, Jack T., Garrison, Brian S., Lee, Philip, Lu, Timothy K., Lee, Gary

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TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet von Lin, Jack T, Martin, Stacey L, Xia, Luxi, Gorham, James D

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Distinctive maturation of in vitro versus in vivo anti-CD40 mAb-matured Dendritic cells in mice von FRLETA, Davor, LIN, Jack T, QUEZADA, Sergio A, WADE, Terri K, BARTH, Richard J, NOELLE, Randolph J, WADE, William F

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Genetic Regulation of Autoimmune Disease: BALB/c Background TGF-β1-Deficient Mice Develop Necroinflammatory IFN-γ-Dependent Hepatitis von Gorham, James D., Lin, Jack T., Sung, James L., Rudner, Lynnie A., French, Margaret A.

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CD137 Identifies a Population of Regulatory T Cells That Inhibit Anti-Tumor Immune Responses In Adoptive Immunotherapy von Goldstein, Matthew J, Kohrt, Holbrook E, Houot, Roch, Varghese, Bindu, Lin, Jack T, Swanson, Erica, Levy, Ronald

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The Transmembrane E3 Ligase GRAIL Ubiquitinates and Degrades CD83 on CD4 T Cells1 von Su, Leon L., Iwai, Hideyuki, Lin, Jack T., Fathman, C. Garrison

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