ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension von Budas, Grant R, Boehm, Mario, Kojonazarov, Baktybek, Viswanathan, Gayathri, Tian, Xia, Veeroju, Swathi, Novoyatleva, Tatyana, Grimminger, Friedrich, Hinojosa-Kirschenbaum, Ford, Ghofrani, Hossein A, Weissmann, Norbert, Seeger, Werner, Liles, John T, Schermuly, Ralph T

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Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury von Xie, Yuchao, Ramachandran, Anup, Breckenridge, David G., Liles, John T., Lebofsky, Margitta, Farhood, Anwar, Jaeschke, Hartmut

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ASK1 contributes to fibrosis and dysfunction in models of kidney disease von Liles, John T, Corkey, Britton K, Notte, Gregory T, Budas, Grant R, Lansdon, Eric B, Hinojosa-Kirschenbaum, Ford, Badal, Shawn S, Lee, Michael, Schultz, Brian E, Wise, Sarah, Pendem, Swetha, Graupe, Michael, Castonguay, Laurie, Koch, Keith A, Wong, Melanie H, Papalia, Giuseppe A, French, Dorothy M, Sullivan, Theodore, Huntzicker, Erik G, Ma, Frank Y, Nikolic-Paterson, David J, Altuhaifi, Tareq, Yang, Haichun, Fogo, Agnes B, Breckenridge, David G

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ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice von Tesch, Greg H, Ma, Frank Y, Han, Yingjie, Liles, John T, Breckenridge, David G, Nikolic-Paterson, David J

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Cyclophilin Inhibition Protects Against Experimental Acute Kidney Injury and Renal Interstitial Fibrosis von Leong, Khai Gene, Ozols, Elyce, Kanellis, John, Badal, Shawn S., Liles, John T., Nikolic-Paterson, David J., Ma, Frank Y.

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The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model von Schwabl, Philipp, Hambruch, Eva, Budas, Grant R., Supper, Paul, Burnet, Michael, Liles, John T., Birkel, Manfred, Brusilovskaya, Ksenia, Konigshofer, Philipp, Peck-Radosavljevic, Markus, Watkins, William J., Trauner, Michael, Breckenridge, David G., Kremoser, Claus, Reiberger, Thomas

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Non-steroidal FXR agonist cilofexor improves cholestatic liver injury in the Mdr2-/- mouse model of sclerosing cholangitis von Fuchs, Claudia D., Sroda, Natalie, Scharnagl, Hubert, Gupta, Ruchi, Minto, Wesley, Stojakovic, Tatjana, Liles, John T., Budas, Grant, Hollenback, David, Trauner, Michael

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Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine von Reznichenko, Anna, Nair, Viji, Eddy, Sean, Fermin, Damian, Tomilo, Mark, Slidel, Timothy, Ju, Wenjun, Henry, Ian, Badal, Shawn S., Wesley, Johnna D., Liles, John T., Moosmang, Sven, Williams, Julie M., Quinn, Carol Moreno, Bitzer, Markus, Hodgin, Jeffrey B., Barisoni, Laura, Karihaloo, Anil, Breyer, Matthew D., Duffin, Kevin L., Patel, Uptal D., Magnone, Maria Chiara, Bhat, Ratan, Kretzler, Matthias

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Ranolazine reduces remodeling of the right ventricle and provoked arrhythmias in rats with pulmonary hypertension von Liles, John T, Hoyer, Kirsten, Oliver, Jason, Chi, Liguo, Dhalla, Arvinder K, Belardinelli, Luiz

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ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis von Amos, Liv A., Ma, Frank Y., Tesch, Greg H., Liles, John T., Breckenridge, David G., Nikolic‐Paterson, David J., Han, Yingjie

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ASK 1 inhibitor treatment suppresses p38/ JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis von Amos, Liv A., Ma, Frank Y., Tesch, Greg H., Liles, John T., Breckenridge, David G., Nikolic‐Paterson, David J., Han, Yingjie

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Selonsertib Enhances Kidney Protection Beyond Standard of Care in a Hypertensive, Secondary Glomerulosclerosis CKD Model von Badal, Shawn S, Al Tuhaifi, Tareq, Yu, Ya-Fen, Lopez, David, Plato, Craig T, Joly, Kristin, Breckenridge, David G, Yang, Hai-Chun, Liles, John T, Fogo, Agnes B

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An Apoptosis Signal-regulating Kinase 1 Inhibitor Reduces Cardiomyocyte Apoptosis and Infarct Size in a Rat Ischemia-reperfusion Model von Gerczuk, Paul Z, Breckenridge, David G, Liles, John T, Budas, Grant R, Shryock, John C, Belardinelli, Luiz, Kloner, Robert A, Dai, Wangde

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Apoptosis signal-regulating kinase 1 inhibition in in vivo and in vitro models of pulmonary hypertension von Wilson, Kathryn S., Buist, Hanna, Suveizdyte, Kornelija, Liles, John T., Budas, Grant R., Hughes, Colin, MacLean, Margaret R., Johnson, Martin, Church, Alistair C., Peacock, Andrew J., Welsh, David J.

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Effect of binge cocaine treatment on hindlimb vascular function von Pradhan, Leena, Dabisch, Paul A., Liles, John T., Murthy, S. N., Baber, Syed R., Simpson, Scott A., Agrawal, Krishna C., Kadowitz, Philip J.

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Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat von Liles, John T, Ida, Kevin K, Joly, Kristin M, Chapo, Joseph, Plato, Craig F

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Analysis of L-NAME-dependent and -resistant responses to acetylcholine in the rat von Dabisch, Paul A, Liles, John T, Baber, Syed R, Golwala, Neel H, Murthy, S. N, Kadowitz, Philip J

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Selonsertib Reduces TNFα-Induced Markers of Injury and Inflammation in an Organ-on-a-Chip Model of Proximal Tubular Injury: PO0927 von Badal, Shawn S., Velasquez, Maile, Liles, John T.

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Human Translational Data and Preclinical Models Support LPAR1 Antagonist as a Candidate Treatment for Diabetic Kidney Disease: SA-PO240 von Sharma, Monika, Kaushik, Swati, Lopez, David, Kassa, Katie, Minto, Wesley, Hudson, Thomas E., Pandit, Shusil, Badal, Shawn S., Liles, John T., Zagorska, Anna

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A Novel, Small-Molecule Inhibitor of Ketohexokinase Attenuates Tubular Injury, Immune Cell Infiltration, and Renal Failure in Models of Acute and Chronic Kidney Injury: FR-PO993 von Sroda, Natalie, Badal, Shawn S., Gomez, Ivan G., Velasquez, Maile, Ma, Frank Y., Kasun, Zachary A., Jansa, Petr, Nikolic-Paterson, David J., Liles, John T.

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