An insertion–deletion polymorphism in the Interferon Regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases von Dideberg, Vinciane, Kristjansdottir, Gudlaug, Milani, Lili, Libioulle, Cécile, Sigurdsson, Snaevar, Louis, Edouard, Wiman, Ann-Christin, Vermeire, Séverine, Rutgeerts, Paul, Belaiche, Jacques, Franchimont, Denis, Van Gossum, André, Bours, Vincent, Syvänen, Ann-Christine

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease von Barrett, Jeffrey C, Hansoul, Sarah, Nicolae, Dan L, Cho, Judy H, Duerr, Richard H, Rioux, John D, Brant, Steven R, Silverberg, Mark S, Taylor, Kent D, Barmada, M Michael, Bitton, Alain, Dassopoulos, Themistocles, Datta, Lisa Wu, Green, Todd, Griffiths, Anne M, Kistner, Emily O, Murtha, Michael T, Regueiro, Miguel D, Rotter, Jerome I, Schumm, L Philip, Steinhart, A Hillary, Targan, Stephan R, Xavier, Ramnik J, Libioulle, Cécile, Sandor, Cynthia, Lathrop, Mark, Belaiche, Jacques, Dewit, Olivier, Gut, Ivo, Heath, Simon, Laukens, Debby, Mni, Myriam, Rutgeerts, Paul, Van Gossum, André, Zelenika, Diana, Franchimont, Denis, Hugot, Jean-Pierre, de Vos, Martine, Vermeire, Severine, Louis, Edouard, Cardon, Lon R, Anderson, Carl A, Drummond, Hazel, Nimmo, Elaine, Ahmad, Tariq, Prescott, Natalie J, Onnie, Clive M, Fisher, Sheila A, Marchini, Jonathan, Ghori, Jilur, Bumpstead, Suzannah, Gwilliam, Rhian, Tremelling, Mark, Deloukas, Panos, Mansfield, John, Jewell, Derek, Satsangi, Jack, Mathew, Christopher G, Parkes, Miles, Georges, Michel, Daly, Mark J

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility von Baba, Nobuyasu, Villani, Alexandra-Chloé, Belaiche, Jacques, Rutgeerts, Paul, Louis, Edouard, Fortin, Paul R, Silverberg, Mark S, Gaudet, Daniel, Bitton, Alain, Libioulle, Cécile, Langelier, Diane, Vermeire, Severine, Lemire, Mathieu, Fortin, Geneviève, Sarfati, Marika, Cohen, Albert, Collette, Catherine, Franchimont, Denis, Wither, Joan E, Hudson, Thomas J, Rioux, John D

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Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4 von Libioulle, Cécile, Louis, Edouard, Hansoul, Sarah, Sandor, Cynthia, Farnir, Frédéric, Franchimont, Denis, Vermeire, Séverine, Dewit, Olivier, de Vos, Martine, Dixon, Anna, Demarche, Bruno, Gut, Ivo, Heath, Simon, Foglio, Mario, Liang, Liming, Laukens, Debby, Mni, Myriam, Zelenika, Diana, Van Gossum, André, Rutgeerts, Paul, Belaiche, Jacques, Lathrop, Mark, Georges, Michel

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Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease von Georges, Michel, Momozawa, Yukihide, Mni, Myriam, Nakamura, Kayo, Coppieters, Wouter, Almer, Sven, Amininejad, Leila, Cleynen, Isabelle, Colombel, Jean-Frédéric, de Rijk, Peter, Dewit, Olivier, Finkel, Yigael, Gassull, Miquel A, Goossens, Dirk, Laukens, Debby, Lémann, Marc, Libioulle, Cécile, O'Morain, Colm, Reenaers, Catherine, Rutgeerts, Paul, Tysk, Curt, Zelenika, Diana, Lathrop, Mark, Del-Favero, Jurgen, Hugot, Jean-Pierre, de Vos, Martine, Franchimont, Denis, Vermeire, Severine, Louis, Edouard

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Six Novel Variants in the MKRN3 Gene Causing Central Precocious Puberty von Gernay, Caroline, Brachet, Cecile, Boros, Emese, Tenoutasse, Sylvie, Libioulle, Cecile, Heinrichs, Claudine

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C2orf69 mutations disrupt mitochondrial function and cause a multisystem human disorder with recurring autoinflammation von Lausberg, Eva, Giesselmann, Sebastian, Dewulf, Joseph P., Wiame, Elsa, Holz, Anja, Salvarinova, Ramona, van Karnebeek, Clara D., Klemm, Patricia, Ohl, Kim, Mull, Michael, Braunschweig, Till, Weis, Joachim, Sommer, Clemens J., Demuth, Stephanie, Haase, Claudia, Stollbrink-Peschgens, Claudia, Debray, Francois-Guillaume, Libioulle, Cecile, Choukair, Daniela, Oommen, Prasad T., Borkhardt, Arndt, Surowy, Harald, Wieczorek, Dagmar, Wagner, Norbert, Meyer, Robert, Eggermann, Thomas, Begemann, Matthias, Van Schaftingen, Emile, Hausler, Martin, Tenbrock, Klaus, van den Heuvel, Lambert, Elbracht, Miriam, Kurth, Ingo, Kraft, Florian

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Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis von Laukens, Debby, Georges, Michel, Libioulle, Cécile, Sandor, Cynthia, Mni, Myriam, Vander Cruyssen, Bert, Peeters, Harald, Elewaut, Dirk, De Vos, Martine

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3-years experience review of neonatal screening for hemoglobin disorders using tandem mass spectrometry von Boemer, François, Cornet, Yves, Libioulle, Cécile, Segers, Karin, Bours, Vincent, Schoos, Roland

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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease von Rivas, Manuel A, Daly, Mark J, Beaudoin, Mélissa, Gardet, Agnes, Stevens, Christine, Sharma, Yashoda, Zhang, Clarence K, Boucher, Gabrielle, Ripke, Stephan, Ellinghaus, David, Burtt, Noel, Fennell, Tim, Kirby, Andrew, Latiano, Anna, Goyette, Philippe, Green, Todd, Halfvarson, Jonas, Haritunians, Talin, Korn, Joshua M, Kuruvilla, Finny, Lagacé, Caroline, Neale, Benjamin, Lo, Ken Sin, Schumm, Phil, Törkvist, Leif, Dubinsky, Marla C, Brant, Steven R, Silverberg, Mark S, Duerr, Richard H, Altshuler, David, Gabriel, Stacey, Lettre, Guillaume, Franke, Andre, D'Amato, Mauro, McGovern, Dermot P B, Cho, Judy H, Rioux, John D, Xavier, Ramnik J

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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci von Jostins, Luke, Dubinsky, Marla, Baldassano, Robert N, Cho, Judy H, Mathew, Christopher G, Cohen, Albert, Prescott, Natalie J, Barclay, Murray, Annese, Vito, Silverberg, Mark S, Taylor, Kent D, Weersma, Rinse K, Satsangi, Jack, Haritunians, Talin, Roberts, Rebecca, Steinhart, A Hillary, Libioulle, Cecile, Regueiro, Miguel, Stronati, Laura, De Vos, Martine, Sans, Miquel, Anderson, Carl A, Wilson, David, Levine, Arie, Glas, Jürgen, McGovern, Dermot P B, Ellinghaus, David, Daly, Mark J, Laukens, Debby, Proctor, Deborah D, Lawrance, Ian, Raychaudhuri, Soumya, Gearry, Richard, Latiano, Anna, Cottone, Mario, Edwards, Cathryn, Sharma, Yashoda, Duerr, Richard H, Florin, Tim, Louis, Edouard, Rutgeerts, Paul, Ahmad, Tariq, Griffiths, Anne M, Hakonarson, Hakon, Festen, Eleonora M, Schumm, Philip, Sanderson, Jeremy, Franchimont, Denis, Verspaget, Hein W, Barrett, Jeffrey C, Lemann, Marc, Kullak-Ublick, Gerd, Rioux, John D, Newman, William, Stokkers, Pieter C F, Brant, Steven R, Balschun, Tobias, Karban, Amir, Montgomery, Grant W, Brand, Stephan, Kugathasan, Subra, D'Amato, Mauro, Lees, Charlie W, Denson, Ted, Halfvarson, Jonas, Bis, Joshua C, Schreiber, Stefan, D'Inca, Renata, Simms, Lisa A, Bumpstead, Suzanne, Torkvist, Leif, Mowat, Craig, Russell, Richard, Bayless, Theodore M, Seibold, Frank, Vermeire, Severine, Franke, Andre, Lee, James, Green, Todd, Van Gossum, Andre, Colombel, Jean-Frederick, Georges, Michel, Walters, Thomas, Wijmenga, Cisca, Targan, Stephan R, Radford-Smith, Graham L, Guthery, Stephen L, Mansfield, John C, Büning, Carsten, Wang, Kai, Parkes, Miles, Panés, Julián, Phillips, Anne, Rotter, Jerome I, Whiteman, David, Hugot, Jean-Pierre

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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 von Anderson, Carl A, Boucher, Gabrielle, Lees, Charlie W, Franke, Andre, D'Amato, Mauro, Lee, James C, Goyette, Philippe, Latiano, Anna, Lagace, Caroline, Scott, Regan, Amininejad, Leila, Bumpstead, Suzannah, Baidoo, Leonard, Baldassano, Robert N, Brand, Stephan, Buning, Carsten, Colombel, Jean-Frederic, Denson, Lee A, DEVOS, Martine, Dubinsky, Marla, Edwards, Cathryn, Ellinghaus, David, Fehrmann, Rudolf S N, Florin, Timothy, Franchimont, Denis, Franke, Lude, Georges, Michel, Glas, Jurgen, Glazer, Nicole L, Guthery, Stephen L, Haritunians, Talin, Hayward, Nicholas K, Hugot, Jean-Pierre, Jobin, Gilles, Laukens, Debby, Lawrance, Ian, Lemann, Marc, Levine, Arie, LIBIOULLE, Cécile, Louis, Edouard, McGovern, Dermot P, Montgomery, Grant W, Morley, Katherine I, Mowat, Craig, Ng, Aylwin, Newman, William, Ophoff, Roel A, Papi, Laura, Palmieri, Orazio, Peyrin-Biroulet, Laurent, Panes, Julian, Phillips, Anne, Proctor, Deborah D, Roberts, Rebecca, Russell, Richard, Rutgeerts, Paul, Sanderson, Jeremy, Sans, Miquel, Sharma, Yashoda, Simms, Lisa A, Seielstad, Mark, Steinhart, A Hillary, Targan, Stephan R, van den Berg, Leonard H, Vatn, Morten, Walters, Thomas, Wijmenga, Cisca, Wilson, David C, Westra, Harm-Jan, Xavier, Ramnik J, Zhao, Zhen Z, Ponsioen, Cyriel Y, Andersen, Vibeke, Torkvist, Leif, Gazouli, Maria, Anagnou, Nicholas P, Sventoraityte, Jurgita, Mansfield, John C, Kugathasan, Subra, Silverberg, Mark S, Halfvarson, Jonas, Rotter, Jerome I, Mathew, Christopher G, Griffiths, Anne M, Gearry, Richard, Ahmad, Tariq, Brant, Steven R, Chamaillard, Mathias, Satsangi, Jack, Schreiber, Stefan, Daly, Mark J, Barrett, Jeffrey C, Parkes, Miles, Annese, Vito, Hakonarson, Hakon, Radford-Smith, Graham, Duerr, Richard H, Vermeire, Severine, Weersma, Rinse K, Rioux, John D

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Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology von Rossin, Elizabeth J, Lage, Kasper, Raychaudhuri, Soumya, Xavier, Ramnik J, Tatar, Diana, Benita, Yair, Cotsapas, Chris, Daly, Mark J

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Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis von Beaudoin, Mélissa, Goyette, Philippe, Boucher, Gabrielle, Lo, Ken Sin, Rivas, Manuel A, Stevens, Christine, Alikashani, Azadeh, Ladouceur, Martin, Ellinghaus, David, Törkvist, Leif, Goel, Gautam, Lagacé, Caroline, Annese, Vito, Bitton, Alain, Begun, Jakob, Brant, Steve R, Bresso, Francesca, Cho, Judy H, Duerr, Richard H, Halfvarson, Jonas, McGovern, Dermot P B, Radford-Smith, Graham, Schreiber, Stefan, Schumm, Philip L, Sharma, Yashoda, Silverberg, Mark S, Weersma, Rinse K, D'Amato, Mauro, Vermeire, Severine, Franke, Andre, Lettre, Guillaume, Xavier, Ramnik J, Daly, Mark J, Rioux, John D

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Genetics of ulcerative colitis: the come-back of interleukin 10 von Louis, Edouard, Libioulle, Cecile, Reenaers, Catherine, Belaiche, Jacques, Georges, Michel

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A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants von Sharma, Manu, Ioannidis, John P A, Aasly, Jan O, Annesi, Grazia, Brice, Alexis, Bertram, Lars, Bozi, Maria, Barcikowska, Maria, Crosiers, David, Clarke, Carl E, Facheris, Maurizio F, Farrer, Matthew, Garraux, Gaetan, Gispert, Suzana, Auburger, Georg, Vilariño-Güell, Carles, Hadjigeorgiou, Georgios M, Hicks, Andrew A, Hattori, Nobutaka, Jeon, Beom S, Jamrozik, Zygmunt, Krygowska-Wajs, Anna, Lesage, Suzanne, Lill, Christina M, Lin, Juei-Jueng, Lynch, Timothy, Lichtner, Peter, Lang, Anthony E, Libioulle, Cecile, Murata, Miho, Mok, Vincent, Jasinska-Myga, Barbara, Mellick, George D, Morrison, Karen E, Meitnger, Thomas, Zimprich, Alexander, Opala, Grzegorz, Pramstaller, Peter P, Pichler, Irene, Park, Sung Sup, Quattrone, Aldo, Rogaeva, Ekaterina, Ross, Owen A., Stefanis, Leonidas, Stockton, Joanne D, Satake, Wataru, Silburn, Peter A, Strom, Tim M, Theuns, Jessie, Tan, Eng- King, Toda, Tatsushi, Tomiyama, Hiroyuki, Uitti, Ryan J, Van Broeckhoven, Christine, Wirdefeldt, Karin, Wszolek, Zbigniew, Xiromerisiou, Georgia, Yomono, Harumi S, Yueh, Kuo-Chu, Zhao, Yi, Gasser, Thomas, Maraganore, Demetrius, Krüger, Rejko

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C2orf69 mutations disrupt mitochondrial function and cause a multisystem human disorder with recurring autoinflammation von Lausberg, Eva, Gießelmann, Sebastian, Dewulf, Joseph P, Wiame, Elsa, Holz, Anja, Salvarinova, Ramona, Van karnebeek, Clara D, Klemm, Patricia, Ohl, Kim, Mull, Michael, Braunschweig, Till, Weis, Joachim, Sommer, Clemens J, Demuth, Stephanie, Haase, Claudia, Stollbrink-Peschgens, Claudia, Debray, François-Guillaume, Libioulle, Cecile, Choukair, Daniela, Oommen, Prasad T, Borkhardt, Arndt, Surowy, Harald, Wieczorek, Dagmar, Wagner, Norbert, Meyer, Robert, Eggermann, Thomas, Begemann, Matthias, Van Schaftingen, Emile, Häusler, Martin, Tenbrock, Klaus, van Den Heuvel, Lambert, Elbracht, Miriam, Kurth, Ingo, Kraft, Florian

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Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis von Villani, Alexandra-Chloé, Lemire, Mathieu, Louis, Edouard, Silverberg, Mark S, Collette, Catherine, Fortin, Geneviève, Nimmo, Elaine R, Renaud, Yannick, Brunet, Sébastien, Libioulle, Cécile, Belaiche, Jacques, Bitton, Alain, Gaudet, Daniel, Cohen, Albert, Langelier, Diane, Rioux, John D, Arnott, Ian D R, Wild, Gary E, Rutgeerts, Paul, Satsangi, Jack, Vermeire, Séverine, Hudson, Thomas J, Franchimont, Denis

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Common variants at five new loci associated with early-onset inflammatory bowel disease von Hakonarson, Hakon, Zhang, Haitao, Grand, Richard, Hou, Cuiping, Silverberg, Mark S, Muise, Aleixo, Stephens, Michael, Annese, Vito, Grundmeier, Robert, Russell, Richard K, Lee, Jessica, Daly, Mark, Griffiths, Anne, Heyman, Melvin B, Latiano, Anna, Kirschner, Barbara, Imielinski, Marcin, Baldassano, Robert N, Cucchiara, Salvatore, Grant, Struan F A, Flory, James H, Monos, Dimitri S, Saeed, Shehzad, Chiavacci, Rosetta M, Bradfield, Jonathan P, Dallapiccola, Bruno, Denson, Lee, Taylor, Kent, McGovern, Dermot, Dubinsky, Marla, Levine, Arie, Castro, Massimo, Abrams, Debra J, Kugathasan, Subra, Otieno, George, Walters, Thomas D, Frackelton, Edward C, Sleiman, Patrick, Van Limbergen, Johan, Wilson, David C, Essers, Jonah, Glessner, Joseph T, Stempak, Joanne, Guthery, Stephen L, Satsangi, Jack, Ferry, George D, Piccoli, David, Wang, Kai, Kim, Cecilia E

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S1747 Expression of the Prostaglandin E2 Receptor EP4 in Crohn's Disease von Catherine, Reenaers, Libioulle, Cecile, Belaiche, Jacques, Delvenne, Philippe, Georges, Michel, Louis, Edouard

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