Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma von Lee, Alexander H., Sun, Lu, Mochizuki, Aaron Y., Reynoso, Jeremy G., Orpilla, Joey, Chow, Frances, Kienzler, Jenny C., Everson, Richard G., Nathanson, David A., Bensinger, Steven J., Liau, Linda M., Cloughesy, Timothy, Hugo, Willy, Prins, Robert M.

Volltext

Editorial. Sexual harassment in neurosurgery: #UsToo von Kondziolka, Douglas, Liau, Linda M.

Volltext

Neurosurgeons in 2020: the impact of gender on neurosurgical training, family planning, and workplace culture von Thum, Jasmine A., Chang, Diana, Tata, Nalini, Liau, Linda M.

Volltext

Perfusion and diffusion MRI signatures in histologic and genetic subtypes of WHO grade II–III diffuse gliomas von Leu, Kevin, Ott, Garrett A., Lai, Albert, Nghiemphu, Phioanh L., Pope, Whitney B., Yong, William H., Liau, Linda M., Cloughesy, Timothy F., Ellingson, Benjamin M.

Volltext

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma von Cloughesy, Timothy F., Mochizuki, Aaron Y., Orpilla, Joey R., Hugo, Willy, Lee, Alexander H., Davidson, Tom B., Wang, Anthony C., Ellingson, Benjamin M., Rytlewski, Julie A., Sanders, Catherine M., Kawaguchi, Eric S., Du, Lin, Li, Gang, Yong, William H., Gaffey, Sarah C., Cohen, Adam L., Mellinghoff, Ingo K., Lee, Eudocia Q., Reardon, David A., O’Brien, Barbara J., Butowski, Nicholas A., Nghiemphu, Phioanh L., Clarke, Jennifer L., Arrillaga-Romany, Isabel C., Colman, Howard, Kaley, Thomas J., de Groot, John F., Liau, Linda M., Wen, Patrick Y., Prins, Robert M.

Volltext

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Bittinger, Mark A, Driggers, Edward M, Ward, Patrick S, Gross, Stefan, Su, Shinsan M, Liau, Linda M, Dang, Lenny, Fantin, Valeria R, Jang, Hyun Gyung, Marks, Kevin M, White, David W, Vander Heiden, Matthew G, Thompson, Craig B, Rabinowitz, Joshua D, Cantley, Lewis C, Keenan, Marie C, Prins, Robert M, Jin, Shengfang, Bennett, Bryson D, Yen, Katharine E

Volltext

Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients von Fong, Brendan, Jin, Richard, Wang, Xiaoyan, Safaee, Michael, Lisiero, Dominique N, Yang, Isaac, Li, Gang, Liau, Linda M, Prins, Robert M

Volltext

Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy von PRINS, Robert M, SOTO, Horacio, KONKANKIT, Vera, ODESA, Sylvia K, ESKIN, Ascia, YONG, William H, NELSON, Stanley F, LIAU, Linda M

Volltext

NF1 mutation drives neuronal activity-dependent initiation of optic glioma von Pan, Yuan, Hysinger, Jared D., Barron, Tara, Schindler, Nicki F., Cobb, Olivia, Guo, Xiaofan, Yalçın, Belgin, Anastasaki, Corina, Mulinyawe, Sara B., Ponnuswami, Anitha, Scheaffer, Suzanne, Ma, Yu, Chang, Kun-Che, Xia, Xin, Toonen, Joseph A., Lennon, James J., Gibson, Erin M., Huguenard, John R., Liau, Linda M., Goldberg, Jeffrey L., Monje, Michelle, Gutmann, David H.

Volltext

Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients von Yong, William H, Shabihkhani, Maryam, Telesca, Donatello, Yang, Shuai, Tso, Jonathan L, Menjivar, Jimmy C, Wei, Bowen, Lucey, Gregory M, Mareninov, Sergey, Chen, Zugen, Liau, Linda M, Lai, Albert, Nelson, Stanley F, Cloughesy, Timothy F, Tso, Cho-Lea

Volltext

Detection of immune responses after immunotherapy in glioblastoma using PET and MRI von Antonios, Joseph P., Soto, Horacio, Everson, Richard G., Moughon, Diana L., Wang, Anthony C., Orpilla, Joey, Radu, Caius, Ellingson, Benjamin M., Lee, Jason T., Cloughesy, Timothy, Phelps, Michael E., Czernin, Johannes, Liau, Linda M., Prins, Robert M.

Volltext

Phase II Study of Bevacizumab Plus Temozolomide During and After Radiation Therapy for Patients With Newly Diagnosed Glioblastoma Multiforme von LAI, Albert, TRAN, Anh, PHUPHANICH, Surasak, BLACK, Keith, PEAK, Scott, GREEN, Richard M, SPIER, Cynthia E, KOLEVSKA, Tatjana, POLIKOFF, Jonathan, FEHRENBACHER, Louis, ELASHOFF, Robert, CLOUGHESY, Timothy, NGHIEMPHU, Phioanh L, POPE, Whitney B, SOLIS, Orestes E, SELCH, Michael, FILKA, Emese, YONG, William H, MISCHEL, Paul S, LIAU, Linda M

Volltext

Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin von LAI, Albert, KHARBANDA, Samir, ELLINGSON, Benjamin M, BOWERS, Chauncey W, SORIANO, Robert H, SCHMIDT, Nils O, MOHAN, Sankar, YONG, William H, SESHAGIRI, Somasekar, MODRUSAN, Zora, ZHAOSHI JIANG, ALDAPE, Kenneth D, POPE, Whitney B, MISCHEL, Paul S, LIAU, Linda M, ESCOVEDO, Cameron J, WEIDONG CHEN, PHIOANH LEIA NGHIEMPHU, DAVID JAMES, C, PRADOS, Michael D, WESTPHAL, Manfred, LAMSZUS, Katrin, CLOUGHESY, Timothy, TRAN, Anh, PHILLIPS, Heidi S, SOLIS, Orestes E, PEALE, Franklin, FORREST, William F, PUJARA, Kanan, CARRILLO, Jose A, PANDITA, Ajay

Volltext

CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis von Minami, Jenna K., Morrow, Danielle, Bayley, Nicholas A., Fernandez, Elizabeth G., Salinas, Jennifer J., Tse, Christopher, Zhu, Henan, Su, Baolong, Plawat, Rhea, Jones, Anthony, Sammarco, Alessandro, Liau, Linda M., Graeber, Thomas G., Williams, Kevin J., Cloughesy, Timothy F., Dixon, Scott J., Bensinger, Steven J., Nathanson, David A.

Volltext

TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial von Everson, Richard G., Hugo, Willy, Sun, Lu, Antonios, Joseph, Lee, Alexander, Ding, Lizhong, Bu, Melissa, Khattab, Sara, Chavez, Carolina, Billingslea-Yoon, Emma, Salazar, Andres, Ellingson, Benjamin M., Cloughesy, Timothy F., Liau, Linda M., Prins, Robert M.

Volltext

Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma von Antonios, Joseph P, Soto, Horacio, Everson, Richard G, Moughon, Diana, Orpilla, Joey R, Shin, Namjo P, Sedighim, Shaina, Treger, Janet, Odesa, Sylvia, Tucker, Alexander, Yong, William H, Li, Gang, Cloughesy, Timothy F, Liau, Linda M, Prins, Robert M

Volltext

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Marks, Kevin M, Rabinowitz, Joshua D, Dang, Lenny, Gross, Stefan, Fantin, Valeria R, Keenan, Marie C, Driggers, Edward M, Bennett, Bryson D, Jang, Hyun Gyung, Liau, Linda M, Ward, Patrick S, Jin, Shengfang, Yen, Katharine E, Su, Shinsan M, Prins, Robert M, Vander Heiden, Matthew G, White, David W, Cantley, Lewis C, Thompson, Craig B, Bittinger, Mark A

Volltext

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy von Pope, Whitney B., Prins, Robert M., Albert Thomas, M., Nagarajan, Rajakumar, Yen, Katharine E., Bittinger, Mark A., Salamon, Noriko, Chou, Arthur P., Yong, William H., Soto, Horacio, Wilson, Neil, Driggers, Edward, Jang, Hyun G., Su, Shinsan M., Schenkein, David P., Lai, Albert, Cloughesy, Timothy F., Kornblum, Harley I., Wu, Hong, Fantin, Valeria R., Liau, Linda M.

Volltext

Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation von Davidson, Tom B, Lee, Alexander, Hsu, Melody, Sedighim, Shaina, Orpilla, Joey, Treger, Janet, Mastall, Max, Roesch, Saskia, Rapp, Carmen, Galvez, Mildred, Mochizuki, Aaron, Antonios, Joseph, Garcia, Alejandro, Kotecha, Nikesh, Bayless, Nicholas, Nathanson, David, Wang, Anthony, Everson, Richard, Yong, William H, Cloughesy, Timothy F, Liau, Linda M, Herold-Mende, Christel, Prins, Robert M

Volltext

Human IDH mutant 1p/19q co-deleted gliomas have low tumor acidity as evidenced by molecular MRI and PET: a retrospective study von Yao, Jingwen, Hagiwara, Akifumi, Raymond, Catalina, Shabani, Soroush, Pope, Whitney B., Salamon, Noriko, Lai, Albert, Ji, Matthew, Nghiemphu, Phioanh L., Liau, Linda M., Cloughesy, Timothy F., Ellingson, Benjamin M.

Volltext