Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development von Gui, Xun, Deng, Mi, Song, Hao, Chen, Yuanzhi, Xie, Jingjing, Li, Zunling, He, Licai, Huang, Fangfang, Xu, Yixiang, Anami, Yasuaki, Yu, Hai, Yu, Chenyi, Li, Leike, Yuan, Zihao, Xu, Xiaoying, Wang, Qihui, Chai, Yan, Huang, Tao, Shi, Yi, Tsuchikama, Kyoji, Liao, X Charlene, Xia, Ningshao, Gao, George F, Zhang, Ningyan, Zhang, Cheng Cheng, An, Zhiqiang

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Blocking LAIR1 signaling in immune cells inhibits tumor development von Xie, Jingjing, Gui, Xun, Deng, Mi, Chen, Heyu, Chen, Yuanzhi, Liu, Xiaoye, Ku, Zhiqiang, Tan, Lingxiao, Huang, Ryan, He, Yubo, Zhang, Bruce, Lewis, Cheryl, Chen, Kenian, Xu, Lin, Xu, Jian, Huang, Tao, Liao, X Charlene, Zhang, Ningyan, An, Zhiqiang, Zhang, Cheng Cheng

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Phase 1 Randomized, Double-Blind, Placebo-Controlled Study of RG7667, an Anticytomegalovirus Combination Monoclonal Antibody Therapy, in Healthy Adults von Ishida, Julie H, Burgess, Tracy, Derby, Michael A, Brown, Pearline A, Maia, Mauricio, Deng, Rong, Emu, Brinda, Feierbach, Becket, Fouts, Ashley E, Liao, X Charlene, Tavel, Jorge A

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Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton’s Tyrosine Kinase Inhibitor von Liu, Lichuan, Halladay, Jason S., Shin, Young, Wong, Susan, Coraggio, Melis, La, Hank, Baumgardner, Matthew, Le, Hoa, Gopaul, Sashi, Boggs, Jason, Kuebler, Peter, Davis, John C., Liao, X. Charlene, Lubach, Joseph W., Deese, Alan, Sowell, C. Gregory, Currie, Kevin S., Young, Wendy B., Khojasteh, S. Cyrus, Hop, Cornelis E.C.A., Wong, Harvey

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Phase I dose escalation study of IO-108, an anti-LILRB2 antibody, in patients with advanced solid tumors von Taylor, Matthew H, Naing, Aung, Powderly, John, Woodard, Paul, Chung, Luke, Lin, Wen Hong, Tian, Hongyu, Siemers, Nathan, Xiang, Hong, Deng, Rong, Hong, Kyu, Valencia, Donna, Huang, Tao, Zhu, Ying, Liao, X Charlene, Schebye, Xiao Min, Patel, Manish R

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LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration von Deng, Mi, Gui, Xun, Kim, Jaehyup, Xie, Li, Chen, Weina, Li, Zunling, He, Licai, Chen, Yuanzhi, Chen, Heyu, Luo, Weiguang, Lu, Zhigang, Xie, Jingjing, Churchill, Hywyn, Xu, Yixiang, Zhou, Zhan, Wu, Guojin, Yu, Chenyi, John, Samuel, Hirayasu, Kouyuki, Nguyen, Nam, Liu, Xiaoye, Huang, Fangfang, Li, Leike, Deng, Hui, Tang, Haidong, Sadek, Ali H., Zhang, Lingbo, Huang, Tao, Zou, Yizhou, Chen, Benjamin, Zhu, Hong, Arase, Hisashi, Xia, Ningshao, Jiang, Youxing, Collins, Robert, You, M. James, Homsi, Jade, Unni, Nisha, Lewis, Cheryl, Chen, Guo-Qiang, Fu, Yang-Xin, Liao, X. Charlene, An, Zhiqiang, Zheng, Junke, Zhang, Ningyan, Zhang, Cheng Cheng

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304 Antagonistic antibodies targeting LAIR1 enhance T lymphocyte activation and promote inflammatory phenotypes in myeloid cells von Huang, Tao, Bonnans, Caroline, Costa, Maria Jose, Tabrizi, Azita, Ma, Jing-Tyan, Xie, Jingjing, Chen, Heyu, Hong, Kyu, McCutcheon, Krista, Stafford, Ryan, Tian, Hongyu, Zhang, Cheng Cheng, Gui, Xun, Zhang, Ningyan, An, Zhiqiang, Charlene Liao, X, Song, An

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686 Preclinical characterization of a novel therapeutic antibody targeting LILRB2 von Costa, Maria Jose, Stafford, Ryan, Ku, Zhiqiang, Ma, Jing-Tyan, McCutcheon, Krista, Liu, Xiaoye, Chen, Heyu, Hong, Kyu, Huang, Tao, Zhang, Ningyan, An, Zhiqiang, Zhang, Cheng Cheng, Charlene Liao, X, Song, An

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Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant... von Ishida, Julie H, Patel, Anita, Mehta, Aneesh K, Gatault, Philippe, McBride, Jacqueline M, Burgess, Tracy, Derby, Michael A, Snydman, David R, Emu, Brinda, Feierbach, Becket, Fouts, Ashley E, Maia, Mauricio, Deng, Rong, Rosenberger, Carrie M, Gennaro, Lynn A, Striano, Natalee S, Liao, X Charlene, Tavel, Jorge A

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A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma von Harris, Jeffrey M, Maciuca, Romeo, Bradley, Mary S, Cabanski, Christopher R, Scheerens, Heleen, Lim, Jeremy, Cai, Fang, Kishnani, Mona, Liao, X Charlene, Samineni, Divya, Zhu, Rui, Cochran, Colette, Soong, Weily, Diaz, Joseph D, Perin, Patrick, Tsukayama, Miguel, Dimov, Dimo, Agache, Ioana, Kelsen, Steven G

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Pharmacokinetics and Exposure-Response Analysis of RG7667, a Combination of Two Anticytomegalovirus Monoclonal Antibodies, in a Phase 2a Randomized Trial To Prevent Cytomegalovirus... von Deng, Rong, Wang, Yehong, Maia, Mauricio, Burgess, Tracy, McBride, Jacqueline M, Liao, X Charlene, Tavel, Jorge A, Hanley, William D

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Racial profiling harms science von Lu, Shan, Han, Zhe, Hung, Mien-Chie, Xu, Jianming, Xu, Yong, Zheng, Pan, Zheng, Zhi-Ming, Zou, Lee, Li, Zihai, Zheng, Lei, Kang, Yibin, Yang, Yingzi, He, Lin, Liao, X. Charlene, Yu, Hongtao, Yue, Zhenyu, Liu, Shan-Lu, Zheng, Hui

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Impaired Cytokine Signaling in Mice Lacking the IL-1 Receptor-Associated Kinase von Thomas, James A, Allen, Jerry L, Tsen, May, Dubnicoff, Todd, Danao, Jay, Liao, X. Charlene, Cao, Zhaodan, Wasserman, Steven A

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A Novel E3 Ubiquitin Ligase TRAC-1 Positively Regulates T Cell Activation von Zhao, Haoran, Li, Connie C, Pardo, Jorge, Chu, Peter C, Liao, Charlene X, Huang, Jianing, Dong, John G, Zhou, Xiulan, Huang, Qi, Huang, Betty, Bennett, Mark K, Molineaux, Susan M, Lu, Henry, Daniel-Issakani, Sarkiz, Payan, Donald G, Masuda, Esteban S

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Systematic identification of regulatory proteins critical for T-cell activation von Chu, Peter, Pardo, Jorge, Zhao, Haoran, Li, Connie C, Pali, Erlina, Shen, Mary M, Qu, Kunbin, Yu, Simon X, Huang, Betty Cb, Yu, Peiwen, Masuda, Esteban S, Molineaux, Susan M, Kolbinger, Frank, Aversa, Gregorio, de Vries, Jan, Payan, Donald G, Liao, X Charlene

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A Novel Role for p21-Activated Protein Kinase 2 in T Cell Activation von Chu, Peter C, Wu, Jun, Liao, X. Charlene, Pardo, Jorge, Zhao, Haoran, Li, Congfen, Mendenhall, Marcy K, Pali, Erlina, Shen, Mary, Yu, Simon, Taylor, Vanessa C, Aversa, Gregorio, Molineaux, Susan, Payan, Donald G, Masuda, Esteban S

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Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling von Holland, S J, Liao, X C, Mendenhall, M K, Zhou, X, Pardo, J, Chu, P, Spencer, C, Fu, A, Sheng, N, Yu, P, Pali, E, Nagin, A, Shen, M, Yu, S, Chan, E, Wu, X, Li, C, Woisetschlager, M, Aversa, G, Kolbinger, F, Bennett, M K, Molineaux, S, Luo, Y, Payan, D G, Mancebo, H S, Wu, J

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Abstract LB217: A novel bispecific LILRB4/CD3 antibody with potent killing of monocytic acute myeloid leukemia cells von Huang, Tao, Hong, Kyu, McCutcheon, Krista, Ma, Jing-Tyan, Zhu, Ying, Deng, Mi, Zhang, Cheng Cheng, Woodard, Paul, Xiang, Hong, Schebye, Xiao Min, Liao, X. Charlene

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Abstract CT209: A first-in-human phase 1 trial of IO-108, an antagonist antibody targeting LILRB2 (ILT4), as monotherapy and in combination with pembrolizumab in adult patients wit... von Powderly, John, Patel, Manish, Woodard, Paul, Chung, Luke, Tian, Hongyu, Wieland, Elizabeth, Hong, Kyu, Costa, Maria Jose, Liao, X. Charlene, Taylor, Matthew

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Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4 + T Cells von Fowell, Deborah J, Shinkai, Kanade, Liao, X.Charlene, Beebe, Amy M, Coffman, Robert L, Littman, Dan R, Locksley, Richard M

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