Routine sub-2.5 Å cryo-EM structure determination of GPCRs von Danev, Radostin, Belousoff, Matthew, Liang, Yi-Lynn, Zhang, Xin, Eisenstein, Fabian, Wootten, Denise, Sexton, Patrick M.

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Phase-plate cryo-EM structure of a class B GPCR–G-protein complex von Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M., Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K., Wootten, Denise, Skiniotis, Georgios, Sexton, Patrick M.

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Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation von Deganutti, Giuseppe, Liang, Yi-Lynn, Zhang, Xin, Khoshouei, Maryam, Clydesdale, Lachlan, Belousoff, Matthew J., Venugopal, Hari, Truong, Tin T., Glukhova, Alisa, Keller, Andrew N., Gregory, Karen J., Leach, Katie, Christopoulos, Arthur, Danev, Radostin, Reynolds, Christopher A., Zhao, Peishen, Sexton, Patrick M., Wootten, Denise

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Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists von Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M., Wootten, Denise

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Activation of the GLP-1 receptor by a non-peptidic agonist von Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M., Wootten, Denise

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Structure and dynamics of the active Gs-coupled human secretin receptor von Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.

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A structural basis for amylin receptor phenotype von Cao, Jianjun, Belousoff, Matthew J, Liang, Yi-Lynn, Johnson, Rachel M, Josephs, Tracy M, Fletcher, Madeleine M, Christopoulos, Arthur, Hay, Debbie L, Danev, Radostin, Wootten, Denise, Sexton, Patrick M

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Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation von Liang, Yi-Lynn, Belousoff, Matthew J., Zhao, Peishen, Koole, Cassandra, Fletcher, Madeleine M., Truong, Tin T., Julita, Villy, Christopoulos, George, Xu, H. Eric, Zhang, Yan, Khoshouei, Maryam, Christopoulos, Arthur, Danev, Radostin, Sexton, Patrick M., Wootten, Denise

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Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes von Zhang, Xin, Belousoff, Matthew J., Liang, Yi-Lynn, Danev, Radostin, Sexton, Patrick M., Wootten, Denise

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Structure and dynamics of the CGRP receptor in apo and peptide-bound forms von Josephs, Tracy M, Belousoff, Matthew J, Liang, Yi-Lynn, Piper, Sarah J, Cao, Jianjun, Garama, Daniel J, Leach, Katie, Gregory, Karen J, Christopoulos, Arthur, Hay, Debbie L, Danev, Radostin, Wootten, Denise, Sexton, Patrick M

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Recent advances in the determination of G protein-coupled receptor structures von Thal, David M, Vuckovic, Ziva, Draper-Joyce, Christopher J, Liang, Yi-Lynn, Glukhova, Alisa, Christopoulos, Arthur, Sexton, Patrick M

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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics von Vuckovic, Ziva, Wang, Jinan, Pham, Vi, Mobbs, Jesse I, Belousoff, Matthew J, Bhattarai, Apurba, Burger, Wessel A C, Thompson, Geoff, Yeasmin, Mahmuda, Nawaratne, Vindhya, Leach, Katie, van der Westhuizen, Emma T, Khajehali, Elham, Liang, Yi-Lynn, Glukhova, Alisa, Wootten, Denise, Lindsley, Craig W, Tobin, Andrew, Sexton, Patrick, Danev, Radostin, Valant, Celine, Miao, Yinglong, Christopoulos, Arthur, Thal, David M

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Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism von Lei, Saifei, Clydesdale, Lachlan, Dai, Antao, Cai, Xiaoqing, Feng, Yang, Yang, Dehua, Liang, Yi-Lynn, Koole, Cassandra, Zhao, Peishen, Coudrat, Thomas, Christopoulos, Arthur, Wang, Ming-Wei, Wootten, Denise, Sexton, Patrick M.

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Understanding VPAC receptor family peptide binding and selectivity von Piper, Sarah J., Deganutti, Giuseppe, Lu, Jessica, Zhao, Peishen, Liang, Yi-Lynn, Lu, Yao, Fletcher, Madeleine M., Hossain, Mohammed Akhter, Christopoulos, Arthur, Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M., Wootten, Denise

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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex von Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B., Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T., Thal, David M., Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M., Wootten, Denise

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Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor von Liang, Yi-Lynn, Khoshouei, Maryam, Deganutti, Giuseppe, Glukhova, Alisa, Koole, Cassandra, Peat, Thomas S., Radjainia, Mazdak, Plitzko, Jürgen M., Baumeister, Wolfgang, Miller, Laurence J., Hay, Deborah L., Christopoulos, Arthur, Reynolds, Christopher A., Wootten, Denise, Sexton, Patrick M.

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Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins von Liang, Yi-Lynn, Belousoff, Matthew J, Fletcher, Madeleine M, Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G. B, Miller, Laurence J, Hay, Debbie L, Christopoulos, Arthur, Reynolds, Christopher A, Danev, Radostin, Wootten, Denise, Sexton, Patrick M

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Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR‑G Protein Complexes for Structure Determination von Liang, Yi-Lynn, Zhao, Peishen, Draper-Joyce, Christopher, Baltos, Jo-Anne, Glukhova, Alisa, Truong, Tin T, May, Lauren T, Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M, Furness, Sebastian G. B

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Cryo-EM structure of the active, G s -protein complexed, human CGRP receptor von Liang, Yi-Lynn, Khoshouei, Maryam, Deganutti, Giuseppe, Glukhova, Alisa, Koole, Cassandra, Peat, Thomas S, Radjainia, Mazdak, Plitzko, Jürgen M, Baumeister, Wolfgang, Miller, Laurence J, Hay, Deborah L, Christopoulos, Arthur, Reynolds, Christopher A, Wootten, Denise, Sexton, Patrick M

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Structure of the adenosine-bound human adenosine A1 receptor–Gi complex von Draper-Joyce, Christopher J., Khoshouei, Maryam, Thal, David M., Liang, Yi-Lynn, Nguyen, Anh T. N., Furness, Sebastian G. B., Venugopal, Hariprasad, Baltos, Jo-Anne, Plitzko, Jürgen M., Danev, Radostin, Baumeister, Wolfgang, May, Lauren T., Wootten, Denise, Sexton, Patrick M., Glukhova, Alisa, Christopoulos, Arthur

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