Structural basis for the allosteric regulation and dynamic assembly of DNMT3B von Lu, Jiuwei, Fang, Jian, Zhu, Hongtao, Liang, Kimberly Lu, Khudaverdyan, Nelli, Song, Jikui

Volltext

High prevalence of unawareness of HCV infection status among both HCV-seronegative and seropositive people living with human immunodeficiency virus in Taiwan von Lee, Chun-Yuan, Wu, Pei-Hua, Lu, Meng-Wei, Chen, Tun-Chieh, Lu, Po-Liang

Volltext

DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity von Lu, Changzheng, Guan, Junhong, Lu, Steve, Jin, Qihuang, Rousseau, Benoit, Lu, Tianshi, Stephens, Dennis, Zhang, Hongyi, Zhu, Jiankun, Yang, Mingming, Ren, Zhenhua, Liang, Yong, Liu, Zhida, Han, Chuanhui, Liu, Longchao, Cao, Xuezhi, Zhang, Anli, Qiao, Jian, Batten, Kimberly, Chen, Mingyi, Castrillon, Diego H., Wang, Tao, Li, Bo, Diaz, Luis A., Li, Guo-Min, Fu, Yang-Xin

Volltext

A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology von Wie, Jinhong, Liu, Zhenjiang, Song, Haikun, Tropea, Thomas F., Yang, Lu, Wang, Huanhuan, Liang, Yuling, Cang, Chunlei, Aranda, Kimberly, Lohmann, Joey, Yang, Jing, Lu, Boxun, Chen-Plotkin, Alice S., Luk, Kelvin C., Ren, Dejian

Volltext

RAP2 mediates mechanoresponses of the Hippo pathway von Meng, Zhipeng, Qiu, Yunjiang, Lin, Kimberly C., Kumar, Aditya, Placone, Jesse K., Fang, Cao, Wang, Kuei-Chun, Lu, Shicong, Pan, Margaret, Hong, Audrey W., Moroishi, Toshiro, Luo, Min, Plouffe, Steven W., Diao, Yarui, Ye, Zhen, Park, Hyun Woo, Wang, Xiaoqiong, Yu, Fa-Xing, Chien, Shu, Wang, Cun-Yu, Ren, Bing, Engler, Adam J., Guan, Kun-Liang

Volltext

Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization von Lu, Geming, Zhang, Ruihua, Geng, Shuo, Peng, Liang, Jayaraman, Padmini, Chen, Chun, Xu, Feifong, Yang, Jianjun, Li, Qin, Zheng, Hao, Shen, Kimberly, Wang, Juan, Liu, Xiyu, Wang, Weidong, Zheng, Zihan, Qi, Chen-Feng, Si, Chuanping, He, John Cijiang, Liu, Kebin, Lira, Sergio A., Sikora, Andrew G., Li, Liwu, Xiong, Huabao

Volltext

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma von Pan, Jianbo, Hu, Yingwei, Krek, Azra, Li, Yize, Chen, Lin S., Vasaikar, Suhas, Wu, Yige, Chowdhury, Shrabanti, Wyczalkowski, Matthew A., Kong, Andy, Sethuraman, Sunantha, Avtonomov, Dmitry M., Colaprico, Antonio, Cao, Song, Cho, Kyung-Cho, Kalayci, Selim, Ma, Shiyong, Ruggles, Kelly, Kawaler, Emily, Wen, Bo, Chen, Feng, Edwards, Nathan, Pierorazio, Phillip M., Pavlovich, Christian P., Brominski, Gabriel, Hsieh, James J., Lubinski, Jan, Wiznerowicz, Maciej, Kinsinger, Christopher R., Thiagarajan, Mathangi, Mesri, Mehdi, Hiltke, Tara, Ding, Li, Zhang, Zhen, Omenn, Gilbert S., Cieslik, Marcin, Nesvizhskii, Alexey I., Zhang, Hui, Hashimi, Abdul Samad, Charamut, Alyssa, Druker, Brian J., Tognon, Cristina, Mani, D.R., Rohrer, Daniel C., Tansil, Darlene, Chesla, David, Heiman, David, Wheeler, David, Chan, Doug, Demir, Emek, Wilson, George D., Liu, Hongwei, Zhou, Hua, Day, Jacob, Suh, James, Whiteaker, Jeffrey R., Eschbacher, Jennifer, Chen, Jin, Ketchum, Karen A., Rodland, Karin D., Krug, Karsten, Holloway, Kimberly, Sokoll, Lori J., Cornwell, MacIntosh, Loriaux, Marc, Anderson, Matthew, Ellis, Matthew J., Dyer, Maureen, Burke, Meghan C., Borucki, Melissa, Gillette, Michael A., Birrer, Michael J., Smith, Michael, Khan, Munziba, Roche, Nancy, Edwards, Nathan J., Vatanian, Negin, Tignor, Nicole, Piehowski, Paul, McGarvey, Peter B., Hariharan, Pushpa, Gao, Qingsong, Thangudu, Ratna R., Montgomery, Rebecca, Bremner, Ross, Liu, Ruiyang, Hong, Runyu, Payne, Samuel H., Patel, Shalin, Satpathy, Shankha, Davies, Sherri R., Patil, Snehal, Carter, Sonya, Gabriel, Stacey, Thomas, Stefani N., Carr, Steven A., Skelly, Tara, Borate, Uma, Maruvka, Yosef, Li, Zhi

Volltext

Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): w... von Antinori, Andrea, Clarke, Amanda E, Hung, Chien-Ching, Rockstroh, Jürgen K, Girard, Pierre-Marie, Underwood, Mark, Tenorio, Allan R, Fettiplace, Anna, Smith, Kimberly, Cassetti, Lidia, David, Daniel, Figueras, Laura, Losso, Marcelo, Lupo, Sergio, Porteiro, Norma, Sánchez, Marisa, Shields, Matthew, De Wit, Stephane, Florence, Eric, Goffard, Jean-Christophe, Demeester, Remy, Lacor, Patrick, Vandercam, Bernard, Vandekerckhove, Linos, Szabo, Jason, Bouchaud, Olivier, Chidiac, Christian, Goujard, Cecile, Katlama, Christine, Esser, Stefan, Spinner, Christoph, Stoehr, Albrecht, Caramello, Pietro, Castelli, Francesco, Cattelan, Anna Maria, Di Biagio, Antonio, Gori, Andrea, Maggiolo, Franco, Menzaghi, Barbara, Penco, Giovanni, Rizzardini, Giuliano, Lazzarin, Adriano, Quirino, Tiziano, Viale, Pierluigi, Andrade Villanueva, Jaime, Perez Rios, Alma, Santoscoy Gomez, Mario, Den Hollander, Jan, Rijnders, Bart, Hercilla Vasquez, Luis, Illescas, Luis, Saraiva da Cunha, Jose, Serrão, Rosário, Arbune, Manuela, Jianu, Cristian, Oprea, Anca, Borodkina, Olga, Chernova, Oxana, Gankina, Natalia, Kizhlo, Svetlana, Kulagin, Valeriy, Kurina, Nadezhda, Ryamova, Elena, Voronin, Evgeny, Kaplan, Richard, Lee, Sun Hee, Casado Osorio, Jose L, Force, Luis, Galinda Puerto, Maria Jose, Goenaga Sanchez, Miguel A, Knobel, Hernando, Pasquau Liaño, Juan, Santos Fernandez, Jose Ramon, Torres Perea, Rafael, Troya Garcia, Jesus, Fehr, Jan, Lu, Po-Liang, Yang, Chia-Jui, Bredeek, Fritz, Brinson, Cynthia, Dretler, Robin, Fichtenbaum, Carl, Goldstein, Deborah, Hoffman-Terry, Margaret, Jayaweera, Dushyantha, Kinder, Clifford, Klein, Daniel, Nahass, Ronald, Osiyemi, Olayemi, Overton, Edgar, Prelutsky, David, Ramgopal, Moti, Sims, James, Skiest, Daniel, Slim, Jihad, Gazzard, Brian, Fox, Julie, Johnson, Margaret, Kegg, Stephen, Orkin, Chloe

Volltext

γ-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation von Chen, Hailin, Yu, Tengteng, Lin, Liang, Xing, Lijie, Cho, Shih-Feng, Wen, Kenneth, Aardalen, Kimberly, Oka, Adwait, Lam, Joni, Daley, Mike, Lu, Haihui, Munshi, Nikhil, Anderson, Kenneth C., Tai, Yu-Tzu

Volltext

Epigenetic plasticity potentiates a rapid cyclical shift to and from an aggressive cancer phenotype von Xu, Tong, Li, Hong‐Tao, Wei, Jenny, Li, Meng, Hsieh, Tien‐Chan, Lu, Yi‐Tsung, Lakshminarasimhan, Ranjani, Xu, Rong, Hodara, Emmanuelle, Morrison, Gareth, Gujar, Hemant, Rhie, Suhn Kyong, Siegmund, Kimberly, Liang, Gangning, Goldkorn, Amir

Volltext

Pragmatic randomised clinical trial of proton versus photon therapy for patients with non-metastatic breast cancer: the Radiotherapy Comparative Effectiveness (RadComp) Consortium... von Bekelman, Justin E, Lu, Hien, Pugh, Stephanie, Baker, Kaysee, Berg, Christine D, de Gonzalez, Amy Berrington, Braunstein, Lior Z, Bosch, Walter, Chauhan, Cynthia, Ellenberg, Susan, Fang, L Christine, Freedman, Gary M, Hahn, Elizabeth A, Haffty, B G, Khan, Atif J, Jimenez, Rachel B, Kesslering, Christy, Ky, Bonnie, Lee, Choonsik, Lu, Hsiao-Ming, Mishra, Mark V, Mullins, C Daniel, Mutter, Robert W, Nagda, Suneel, Pankuch, Mark, Powell, Simon N, Prior, Fred W, Schupak, Karen, Taghian, Alphonse G, Wilkinson, J Ben, MacDonald, Shannon M, Cahlon, Oren

Volltext

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging von Liang, Steven H., Chen, Jinshan Michael, Normandin, Marc D., Chang, Jeanne S., Chang, George C., Taylor, Christine K., Trapa, Patrick, Plummer, Mark S., Para, Kimberly S., Conn, Edward L., Lopresti-Morrow, Lori, Lanyon, Lorraine F., Cook, James M., Richter, Karl E. G., Nolan, Charlie E., Schachter, Joel B., Janat, Fouad, Che, Ye, Shanmugasundaram, Veerabahu, Lefker, Bruce A., Enerson, Bradley E., Livni, Elijahu, Wang, Lu, Guehl, Nicolas J., Patnaik, Debasis, Wagner, Florence F., Perlis, Roy, Holson, Edward B., Haggarty, Stephen J., El Fakhri, Georges, Kurumbail, Ravi G., Vasdev, Neil

Volltext

Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia‐induced pulmonary hypertension von Wu, Kang, Zhang, Qian, Wu, Xiongting, Lu, Wenju, Tang, Haiyang, Liang, Zhihao, Gu, Yali, Song, Shanshan, Ayon, Ramon J, Wang, Ziyi, McDermott, Kimberly M, Balistrieri, Angela, Wang, Christina, Black, Stephen M, Garcia, Joe G N, Makino, Ayako, Yuan, Jason X‐J, Wang, Jian

Volltext

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition von Telliez, Jean-Baptiste, Dowty, Martin E, Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, Martin, Banker, Mary Ellen, Vincent, Fabien, Unwalla, Ray, Liang, Sidney, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Yang, Xin, Bauman, Jonathan, Trujillo, John I, Casimiro-Garcia, Agustin, Vajdos, Felix F, Leung, Louis, Geoghegan, Kieran F, Quazi, Amira, Xuan, Dejun, Jones, Lyn, Hett, Erik, Wright, Katherine, Clark, James D, Thorarensen, Atli

Volltext

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clini... von Guinney, Justin, PhD, Wang, Tao, PhD, Laajala, Teemu D, MSc, Winner, Kimberly Kanigel, PhD, Bare, J Christopher, BS, Neto, Elias Chaibub, PhD, Khan, Suleiman A, PhD, Peddinti, Gopal, PhD, Airola, Antti, PhD, Pahikkala, Tapio, PhD, Mirtti, Tuomas, MD, Yu, Thomas, BS, Bot, Brian M, MS, Shen, Liji, PhD, Abdallah, Kald, MD, Norman, Thea, PhD, Friend, Stephen, MD, Stolovitzky, Gustavo, PhD, Soule, Howard, PhD, Sweeney, Christopher J, MBBS, Ryan, Charles J, Prof, Scher, Howard I, Prof, Sartor, Oliver, Prof, Xie, Yang, PhD, Aittokallio, Tero, Prof, Zhou, Fang Liz, MD, Costello, James C, Dr

Volltext

Γ-Secretase Inhibitors Enhance the Potency of BCMA-Targeting T Cell Engagers Against Multiple Myeloma Cells without Adverse Impact on T-Cell Activation and Differentiation von Chen, Hailin, Yu, Tengteng, Lin, Liang, Xing, Lijie, Cho, Shih-Feng, Wen, Kenneth, Aardalen, Kimberly, Daley, Mike, Lu, Haihui, Oka, Adwait, Lam, Joni, Munshi, Nikhil C, Anderson, Kenneth C., Tai, Yu-Tzu

Volltext

Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme von Arguello, Annie, Mahon, Cathal S, Calvert, Meredith E K, Chan, Darren, Dugas, Jason C, Pizzo, Michelle E, Thomsen, Elliot R, Chau, Roni, Damo, Lorna A, Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C, Wang, Junhua, Dennis, Mark S, Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R, Lewcock, Joseph W, Sanchez, Pascal E, Troyer, Matthew D, Harris, Jeffrey M, Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J, Thorne, Robert G, Henry, Anastasia G, Kariolis, Mihalis S

Volltext

Author Correction: A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology von Wie, Jinhong, Liu, Zhenjiang, Song, Haikun, Tropea, Thomas F., Yang, Lu, Wang, Huanhuan, Liang, Yuling, Cang, Chunlei, Aranda, Kimberly, Lohmann, Joey, Yang, Jing, Lu, Boxun, Chen-Plotkin, Alice S., Luk, Kelvin C., Ren, Dejian

Volltext

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma von Clark, David J., Petralia, Francesca, Pan, Jianbo, Hu, Yingwei, Lih, Tung-Shing M., Chang, Hui-Yin, Ma, Weiping, Krek, Azra, Li, Yize, Ozbek, Umut, Wu, Yige, Chowdhury, Shrabanti, Wyczalkowski, Matthew A., Schnaubelt, Michael, Avtonomov, Dmitry M., Kalayci, Selim, Ma, Shiyong, Ruggles, Kelly, Gümüş, Zeynep H., Kawaler, Emily, Edwards, Nathan, Chen, Xi Steven, Antczak, Andrzej, Omelchenko, Tatiana, Kinsinger, Christopher R., Thiagarajan, Mathangi, Mesri, Mehdi, Robles, Ana I., Qian, Jiang, Fenyö, David, Zhang, Bing, Zhang, Zhen, Cieslik, Marcin, Chan, Daniel W., Nesvizhskii, Alexey I., Hashimi, Abdul Samad, Charamut, Alyssa, Druker, Brian J., Tognon, Cristina, Mani, D.R., Rohrer, Daniel C., Tansil, Darlene, Chesla, David, Heiman, David, Wheeler, David, Chan, Doug, Demir, Emek, Modugno, Francesmary, Getz, Gaddy, Wilson, George D., Liu, Hongwei, Zhou, Hua, Day, Jacob, Suh, James, Whiteaker, Jeffrey R., Eschbacher, Jennifer, Chen, Jin, Ketchum, Karen A., Rodland, Karin D., Krug, Karsten, Holloway, Kimberly, Sokoll, Lori J., Cornwell, MacIntosh, Loriaux, Marc, Anderson, Matthew, Ellis, Matthew J., Dyer, Maureen, Burke, Meghan C., Borucki, Melissa, Gillette, Michael A., Birrer, Michael J., Smith, Michael, Khan, Munziba, Roche, Nancy, Edwards, Nathan J., Vatanian, Negin, Tignor, Nicole, Grady, Pamela, Piehowski, Paul, McGarvey, Peter B., Hariharan, Pushpa, Gao, Qingsong, Thangudu, Ratna R., Montgomery, Rebecca, Bremner, Ross, Liu, Ruiyang, Hong, Runyu, Payne, Samuel H., Patel, Shalin, Satpathy, Shankha, Davies, Sherri R., Patil, Snehal, Carter, Sonya, Gabriel, Stacey, Thomas, Stefani N., Carr, Steven A., Skelly, Tara, Borate, Uma, Maruvka, Yosef, Li, Zhi

Volltext

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design von Volgraf, Matthew, Sellers, Benjamin D, Jiang, Yu, Wu, Guosheng, Ly, Cuong Q, Villemure, Elisia, Pastor, Richard M, Yuen, Po-wai, Lu, Aijun, Luo, Xifeng, Liu, Mingcui, Zhang, Shun, Sun, Liang, Fu, Yuhong, Lupardus, Patrick J, Wallweber, Heidi J.A, Liederer, Bianca M, Deshmukh, Gauri, Plise, Emile, Tay, Suzanne, Reynen, Paul, Herrington, James, Gustafson, Amy, Liu, Yichin, Dirksen, Akim, Dietz, Matthias G. A, Liu, Yanzhou, Wang, Tzu-Ming, Hanson, Jesse E, Hackos, David, Scearce-Levie, Kimberly, Schwarz, Jacob B

Volltext