Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects von Mitra, Joy, Guerrero, Erika N., Hegde, Pavana M., Liachko, Nicole F., Wang, Haibo, Vasquez, Velmarini, Gao, Junling, Pandey, Arvind, Taylor, J. Paul, Kraemer, Brian C., Wu, Ping, Boldogh, Istvan, Garruto, Ralph M., Mitra, Sankar, Rao, K. S., Hegde, Muralidhar L.

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The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43 von Liachko, Nicole F, McMillan, Pamela J, Strovas, Timothy J, Loomis, Elaine, Greenup, Lynne, Murrell, Jill R, Ghetti, Bernardino, Raskind, Murray A, Montine, Thomas J, Bird, Thomas D, Leverenz, James B, Kraemer, Brian C

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Protein Kinase CK‑1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis von Salado, Irene G, Redondo, Miriam, Bello, Murilo L, Perez, Concepción, Liachko, Nicole F, Kraemer, Brian C, Miguel, Laetitia, Lecourtois, Magalie, Gil, Carmen, Martinez, Ana, Perez, Daniel I

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Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau von Waldherr, Sarah M., Strovas, Timothy J., Vadset, Taylor A., Liachko, Nicole F., Kraemer, Brian C.

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TDP-43/FUS in motor neuron disease: Complexity and challenges von Guerrero, Erika N, Wang, Haibo, Mitra, Joy, Hegde, Pavana M, Stowell, Sara E, Liachko, Nicole F, Kraemer, Brian C, Garruto, Ralph M, Rao, K S, Hegde, Muralidhar L

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Regulation of TDP-43 phosphorylation in aging and disease von Eck, Randall J., Kraemer, Brian C., Liachko, Nicole F.

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Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy von Liachko, Nicole F, Guthrie, Chris R, Kraemer, Brian C

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Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy von Liachko, Nicole F, Saxton, Aleen D, McMillan, Pamela J, Strovas, Timothy J, Keene, C Dirk, Bird, Thomas D, Kraemer, Brian C

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Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis von Garcia-Toscano, Laura, Currey, Heather N, Hincks, Joshua C, Stair, Jade G, Lehrbach, Nicolas J, Liachko, Nicole F

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CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration von Liachko, Nicole F., McMillan, Pamela J., Guthrie, Chris R., Bird, Thomas D., Leverenz, James B., Kraemer, Brian C.

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Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in Caenorhabditis elegans von Han, Marina, Saxton, Aleen, Currey, Heather, Waldherr, Sarah M, Liachko, Nicole F, Kraemer, Brian C

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Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis von Rojas-Prats, Elisa, Martinez-Gonzalez, Loreto, Gonzalo-Consuegra, Claudia, Liachko, Nicole F., Perez, Concepción, Ramírez, David, Kraemer, Brian C., Martin-Requero, Ángeles, Perez, Daniel I., Gil, Carmen, de Lago, Eva, Martinez, Ana

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Alternative 3' UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD von Eck, Randall J, Valdmanis, Paul N, Liachko, Nicole F, Kraemer, Brian C

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Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration von Eck, Randall J, Stair, Jade G, Kraemer, Brian C, Liachko, Nicole F

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Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets von Jadhav, Vaishnavi S., Stair, Jade G., Eck, Randall J., Smukowski, Samuel N., Currey, Heather N., Toscano, Laura Garcia, Hincks, Joshua C., Latimer, Caitlin S., Valdmanis, Paul N., Kraemer, Brian C., Liachko, Nicole F.

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Tau–RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change von McMillan, Pamela J, Benbow, Sarah J, Uhrich, Rikki, Saxton, Aleen, Baum, Misa, Strovas, Timothy, Wheeler, Jeanna M, Baker, Jeremy, Liachko, Nicole F, Keene, C Dirk, Latimer, Caitlin S, Kraemer, Brian C

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Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration von Taylor, Laura M, McMillan, Pamela J, Liachko, Nicole F, Strovas, Timothy J, Ghetti, Bernardino, Bird, Thomas D, Keene, C Dirk, Kraemer, Brian C

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SPOP loss of function protects against tauopathy von Eck, Randall J, Kow, Rebecca L, Black, Aristide H, Liachko, Nicole F, Kraemer, Brian C

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Tau tubulin kinases in proteinopathy von Taylor, Laura M., McMillan, Pamela J., Kraemer, Brian C., Liachko, Nicole F.

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Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis von Currey, Heather N., Liachko, Nicole F.

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