Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia von Roecker, Anthony J., Reger, Thomas S., Mattern, M. Christa, Mercer, Swati P., Bergman, Jeffrey M., Schreier, John D., Cube, Rowena V., Cox, Christopher D., Li, Dansu, Lemaire, Wei, Bruno, Joseph G., Harrell, C. Meacham, Garson, Susan L., Gotter, Anthony L., Fox, Steven V., Stevens, Joanne, Tannenbaum, Pamela L., Prueksaritanont, Thomayant, Cabalu, Tamara D., Cui, Donghui, Stellabott, Joyce, Hartman, George D., Young, Steven D., Winrow, Christopher J., Renger, John J., Coleman, Paul J.

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Discovery and SAR of hydantoin TACE inhibitors von Yu, Wensheng, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Girijavallabhan, Vinay M., Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Li, Dansu, Lundell, Daniel, Niu, Xiaoda, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle B., Shih, Neng-Yang, Arshad Siddiqui, M., Sun, Jing, Tong, Ling, Umland, Shelby, Wong, Michael K.C., Yang, De-yi, Zhou, Guowei

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2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors von Dai, Chaoyang, Li, Dansu, Popovici-Muller, Janeta, Zhao, Lianyun, Girijavallabhan, Vinay M., Rosner, Kristin E., Lavey, Brian J., Rizvi, Razia, Shankar, Bandarpalle B., Wong, Michael K.C., Guo, Zhuyan, Orth, Peter, Strickland, Corey O., Sun, Jing, Niu, Xiaoda, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Piwinski, John J., Shih, Neng-Yang, Siddiqui, M. Arshad

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Biaryl substituted hydantoin compounds as TACE inhibitors von Yu, Wensheng, Tong, Ling, Kim, Seong Heon, Wong, Michael K.C., Chen, Lei, Yang, De-Yi, Shankar, Bandarpalle B., Lavey, Brian J., Zhou, Guowei, Kosinski, Aneta, Rizvi, Razia, Li, Dansu, Feltz, Robert J., Piwinski, John J., Rosner, Kristin E., Shih, Neng-Yang, Siddiqui, M. Arshad, Guo, Zhuyan, Orth, Peter, Shah, Himanshu, Sun, Jing, Umland, Shelby, Lundell, Daniel J., Niu, Xiaoda, Kozlowski, Joseph A.

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The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors von Rosner, Kristin E., Guo, Zhuyan, Orth, Peter, Shipps, Gerald W., Belanger, David B., Chan, Tin Yau, Curran, Patrick J., Dai, Chaoyang, Deng, Yongqi, Girijavallabhan, Vinay M., Hong, Liwu, Lavey, Brian J., Lee, Joe F., Li, Dansu, Liu, Zhidan, Popovici-Muller, Janeta, Ting, Pauline C., Vaccaro, Henry, Wang, Li, Wang, Tong, Yu, Wensheng, Zhou, Guowei, Niu, Xiaoda, Sun, Jing, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng -Yang, Arshad Siddiqui, M., Strickland, Corey O.

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Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models von Minzel, Waleed, Venkatachalam, Avanthika, Fink, Avner, Hung, Eric, Brachya, Guy, Burstain, Ido, Shaham, Maya, Rivlin, Amitai, Omer, Itay, Zinger, Adar, Elias, Shlomo, Winter, Eitan, Erdman, Paul E., Sullivan, Robert W., Fung, Leah, Mercurio, Frank, Li, Dansu, Vacca, Joseph, Kaushansky, Nathali, Shlush, Liran, Oren, Moshe, Levine, Ross, Pikarsky, Eli, Snir-Alkalay, Irit, Ben-Neriah, Yinon

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Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases von Girijavallabhan, Vinay M., Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Firmansjah, Luke, Li, Dansu, Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Kosinski, Aneta, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Banderpalle B., Shih, Neng-Yang, Siddiqui, M. Arshad, Tong, Ling, Wong, Michael K.C., Yang, De-yi, Yang, Liping, Yu, Wensheng, Zhou, Guowei, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Bian, Hong, Lundell, Daniel, Niu, Xiaoda, Shah, Himanshu, Sun, Jing, Umland, Shelby

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Overcoming Multidrug Resistance in Taxane Chemotherapy von Geney, Raphaël, Ungureanu, Ioana Maria, Li, Dansu, Ojima, Iwao

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A highly epothilone B–resistant A549 cell line with mutations in tubulin that confer drug dependence von Yang, Chia-Ping Huang, Verdier-Pinard, Pascal, Wang, Fang, Lippaine-Horvath, Eva, He, Lifeng, Li, Dansu, Höfle, Gerhard, Ojima, Iwao, Orr, George A, Horwitz, Susan Band

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Structure and activity relationships of tartrate-based TACE inhibitors von Li, Dansu, Popovici-Muller, Janeta, Belanger, David B., Caldwell, John, Dai, Chaoyang, David, Maria, Girijavallabhan, Vinay M., Lavey, Brian J., Lee, Joe F., Liu, Zhidan, Mazzola, Rob, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle, Spitler, Jim, Ting, Pauline C., Vaccaro, Henry, Yu, Wensheng, Zhou, Guowei, Zhu, Zhaoning, Niu, Xiaoda, Sun, Jing, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng-Yang, Shipps, Gerald W., Siddiqui, M. Arshad, Strickland, Corey O.

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Synthetic-lethal interactions between ATR inhibition and functional genetic and proteomic biomarkers to predict responses in endometriosis-associated cancers von Gilad, Oren, Li, Dansu, George, Erin, Chettier, Rakesh, Simpkins, Fiona, Ward, Kenneth, Brown, Eric J

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Pharmacophore Analysis of the Nuclear Oxysterol Receptor LXRα von Spencer, Thomas A, Li, Dansu, Russel, Jonathon S, Collins, Jon L, Bledsoe, Randy K, Consler, Thomas G, Moore, Linda B, Galardi, Cristin M, McKee, David D, Moore, John T, Watson, Michael A, Parks, Derek J, Lambert, Millard H, Willson, Timothy M

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Abstract 3498: Highly specific macrocyclic ATR inhibitors for the targeted treatment of a broad spectrum of cancers showing lack of anemia or neutropenia in pre-clinical animal mod... von Pamarthy, Sahithi, Li, Dansu, Goliadze, Ekaterine, Gill, Tina, Jia, Lanqi, George, Erin, Butler, Laura R., Ragland, Ryan L., Afargan, Michel, Simpkins, Fiona A., Brown, Eric J., Gilad, Oren

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Medicinal Chemistry and Chemical Biology of New Generation Taxane Antitumor Agents von Ojima, Iwao, Geney, Raphaël, Ungureanu, Ioana Maria, Li, Dansu

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Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors von Tong, Ling, Kim, Seong Heon, Rosner, Kristin, Yu, Wensheng, Shankar, Bandarpalle B., Chen, Lei, Li, Dansu, Dai, Chaoyang, Girijavallabhan, Vinay, Popovici-Muller, Janeta, Yang, Liping, Zhou, Guowei, Kosinski, Aneta, Siddiqui, M. Arshad, Shih, Neng-Yang, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Lundell, Daniel, Niu, Xiaoda, Umland, Shelby, Kozlowski, Joseph A.

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Synthesis of 7α-hydroxy derivatives of regulatory oxysterols von Li, Dansu, Spencer, Thomas A

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Benzophenone-containing cholesterol surrogates von Spencer, Thomas A., Wang, Pingzhen, Li, Dansu, Russel, Jonathon S., Blank, David H., Huuskonen, Jarkko, Fielding, Phoebe E., Fielding, Christopher J.

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Key regulatory oxysterols in liver: analysis as Δ4-3-ketone derivatives by HPLC and response to physiological perturbations von Zhang, Zhe, Li, Dansu, Blanchard, Daniel E., Lear, Steven R., Erickson, Sandra K., Spencer, Thomas A.

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IRE1 small molecule inhibitors von Vacca, Joseph P, Bettigole, Sarah, Li, Dansu

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IRE1 small molecule inhibitors von Bettigole, Sarah Elizabeth, Vacca, Joseph P, Li, Dansu

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