SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution von Miller, Christopher A, White, Brian S, Dees, Nathan D, Griffith, Malachi, Welch, John S, Griffith, Obi L, Vij, Ravi, Tomasson, Michael H, Graubert, Timothy A, Walter, Matthew J, Ellis, Matthew J, Schierding, William, DiPersio, John F, Ley, Timothy J, Mardis, Elaine R, Wilson, Richard K, Ding, Li

Volltext

Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia von Klco, Jeffery M., Spencer, David H., Miller, Christopher A., Griffith, Malachi, Lamprecht, Tamara L., O’Laughlin, Michelle, Fronick, Catrina, Magrini, Vincent, Demeter, Ryan T., Fulton, Robert S., Eades, William C., Link, Daniel C., Graubert, Timothy A., Walter, Matthew J., Mardis, Elaine R., Dipersio, John F., Wilson, Richard K., Ley, Timothy J.

Volltext

Mutational landscape and significance across 12 major cancer types von Kandoth, Cyriac, McLellan, Michael D., Vandin, Fabio, Ye, Kai, Niu, Beifang, Lu, Charles, Xie, Mingchao, Zhang, Qunyuan, McMichael, Joshua F., Wyczalkowski, Matthew A., Leiserson, Mark D. M., Miller, Christopher A., Welch, John S., Walter, Matthew J., Wendl, Michael C., Ley, Timothy J., Wilson, Richard K., Raphael, Benjamin J., Ding, Li

Volltext

A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing von Petti, Allegra A., Williams, Stephen R., Miller, Christopher A., Fiddes, Ian T., Srivatsan, Sridhar N., Chen, David Y., Fronick, Catrina C., Fulton, Robert S., Church, Deanna M., Ley, Timothy J.

Volltext

Clonal Architecture of Secondary Acute Myeloid Leukemia von Walter, Matthew J, Shen, Dong, Ding, Li, Shao, Jin, Koboldt, Daniel C, Chen, Ken, Larson, David E, McLellan, Michael D, Dooling, David, Abbott, Rachel, Fulton, Robert, Magrini, Vincent, Schmidt, Heather, Kalicki-Veizer, Joelle, O'Laughlin, Michelle, Fan, Xian, Grillot, Marcus, Witowski, Sarah, Heath, Sharon, Frater, John L, Eades, William, Tomasson, Michael, Westervelt, Peter, DiPersio, John F, Link, Daniel C, Mardis, Elaine R, Ley, Timothy J, Wilson, Richard K, Graubert, Timothy A

Volltext

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential von Wong, Terrence N., Miller, Christopher A., Jotte, Matthew R. M., Bagegni, Nusayba, Baty, Jack D., Schmidt, Amy P., Cashen, Amanda F., Duncavage, Eric J., Helton, Nichole M., Fiala, Mark, Fulton, Robert S., Heath, Sharon E., Janke, Megan, Luber, Kierstin, Westervelt, Peter, Vij, Ravi, DiPersio, John F., Welch, John S., Graubert, Timothy A., Walter, Matthew J., Ley, Timothy J., Link, Daniel C.

Volltext

Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia von Churpek, Jane E., Pyrtel, Khateriaa, Kanchi, Krishna-Latha, Shao, Jin, Koboldt, Daniel, Miller, Christopher A., Shen, Dong, Fulton, Robert, O’Laughlin, Michelle, Fronick, Catrina, Pusic, Iskra, Uy, Geoffrey L., Braunstein, Evan M., Levis, Mark, Ross, Julie, Elliott, Kevin, Heath, Sharon, Jiang, Allan, Westervelt, Peter, DiPersio, John F., Link, Daniel C., Walter, Matthew J., Welch, John, Wilson, Richard, Ley, Timothy J., Godley, Lucy A., Graubert, Timothy A.

Volltext

SomaticSniper: identification of somatic point mutations in whole genome sequencing data von Larson, David E., Harris, Christopher C., Chen, Ken, Koboldt, Daniel C., Abbott, Travis E., Dooling, David J., Ley, Timothy J., Mardis, Elaine R., Wilson, Richard K., Ding, Li

Volltext

The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers von Russler-Germain, David A., Spencer, David H., Young, Margaret A., Lamprecht, Tamara L., Miller, Christopher A., Fulton, Robert, Meyer, Matthew R., Erdmann-Gilmore, Petra, Townsend, R. Reid, Wilson, Richard K., Ley, Timothy J.

Volltext

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression von Spencer, David H., Russler-Germain, David A., Ketkar, Shamika, Helton, Nichole M., Lamprecht, Tamara L., Fulton, Robert S., Fronick, Catrina C., O’Laughlin, Michelle, Heath, Sharon E., Shinawi, Marwan, Westervelt, Peter, Payton, Jacqueline E., Wartman, Lukas D., Welch, John S., Wilson, Richard K., Walter, Matthew J., Link, Daniel C., DiPersio, John F., Ley, Timothy J.

Volltext

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing von Hughes, Andrew E O, Magrini, Vincent, Demeter, Ryan, Miller, Christopher A, Fulton, Robert, Fulton, Lucinda L, Eades, William C, Elliott, Kevin, Heath, Sharon, Westervelt, Peter, Ding, Li, Conrad, Donald F, White, Brian S, Shao, Jin, Link, Daniel C, DiPersio, John F, Mardis, Elaine R, Wilson, Richard K, Ley, Timothy J, Walter, Matthew J, Graubert, Timothy A

Volltext

Co-evolution of tumor and immune cells during progression of multiple myeloma von Liu, Ruiyang, Gao, Qingsong, Foltz, Steven M., Fowles, Jared S., Yao, Lijun, Wang, Julia Tianjiao, Cao, Song, Sun, Hua, Wendl, Michael C., Sethuraman, Sunantha, Weerasinghe, Amila, Rettig, Michael P., Storrs, Erik P., Yoon, Christopher J., Wyczalkowski, Matthew A., McMichael, Joshua F., Kohnen, Daniel R., King, Justin, Goldsmith, Scott R., O’Neal, Julie, Fulton, Robert S., Fronick, Catrina C., Ley, Timothy J., Jayasinghe, Reyka G., Fiala, Mark A., Oh, Stephen T., DiPersio, John F., Vij, Ravi, Ding, Li

Volltext

Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression von Silva-Fisher, Jessica M., Dang, Ha X., White, Nicole M., Strand, Matthew S., Krasnick, Bradley A., Rozycki, Emily B., Jeffers, Gejae G. L., Grossman, Julie G., Highkin, Maureen K., Tang, Cynthia, Cabanski, Christopher R., Eteleeb, Abdallah, Mudd, Jacqueline, Goedegebuure, S. Peter, Luo, Jingqin, Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J., Lockhart, Albert C., Fields, Ryan C., Maher, Christopher A.

Volltext

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes von Graubert, Timothy A, Shen, Dong, Ding, Li, Okeyo-Owuor, Theresa, Lunn, Cara L, Shao, Jin, Krysiak, Kilannin, Harris, Christopher C, Koboldt, Daniel C, Larson, David E, McLellan, Michael D, Dooling, David J, Abbott, Rachel M, Fulton, Robert S, Schmidt, Heather, Kalicki-Veizer, Joelle, O'Laughlin, Michelle, Grillot, Marcus, Baty, Jack, Heath, Sharon, Frater, John L, Nasim, Talat, Link, Daniel C, Tomasson, Michael H, Westervelt, Peter, DiPersio, John F, Mardis, Elaine R, Ley, Timothy J, Wilson, Richard K, Walter, Matthew J

Volltext

BreakDancer: an algorithm for high-resolution mapping of genomic structural variation von Chen, Ken, Wallis, John W, McLellan, Michael D, Larson, David E, Kalicki, Joelle M, Pohl, Craig S, McGrath, Sean D, Wendl, Michael C, Zhang, Qunyuan, Locke, Devin P, Shi, Xiaoqi, Fulton, Robert S, Ley, Timothy J, Wilson, Richard K, Ding, Li, Mardis, Elaine R

Volltext

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100 von Nervi, Bruno, Ramirez, Pablo, Rettig, Michael P., Uy, Geoffrey L., Holt, Matthew S., Ritchey, Julie K., Prior, Julie L., Piwnica-Worms, David, Bridger, Gary, Ley, Timothy J., DiPersio, John F.

Volltext

Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML von Wong, Terrence N., Miller, Christopher A., Klco, Jeffery M., Petti, Allegra, Demeter, Ryan, Helton, Nichole M., Li, Tiandao, Fulton, Robert S., Heath, Sharon E., Mardis, Elaine R., Westervelt, Peter, DiPersio, John F., Walter, Matthew J., Welch, John S., Graubert, Timothy A., Wilson, Richard K., Ley, Timothy J., Link, Daniel C.

Volltext

Background Mutations in Parental Cells Account for Most of the Genetic Heterogeneity of Induced Pluripotent Stem Cells von Young, Margaret A., Larson, David E., Sun, Chiao-Wang, George, Daniel R., Ding, Li, Miller, Christopher A., Lin, Ling, Pawlik, Kevin M., Chen, Ken, Fan, Xian, Schmidt, Heather, Kalicki-Veizer, Joelle, Cook, Lisa L., Swift, Gary W., Demeter, Ryan T., Wendl, Michael C., Sands, Mark S., Mardis, Elaine R., Wilson, Richard K., Townes, Tim M., Ley, Timothy J.

Volltext

Clonal architectures and driver mutations in metastatic melanomas von Ding, Li, Kim, Minjung, Kanchi, Krishna L, Dees, Nathan D, Lu, Charles, Griffith, Malachi, Fenstermacher, David, Sung, Hyeran, Miller, Christopher A, Goetz, Brian, Wendl, Michael C, Griffith, Obi, Cornelius, Lynn A, Linette, Gerald P, McMichael, Joshua F, Sondak, Vernon K, Fields, Ryan C, Ley, Timothy J, Mulé, James J, Wilson, Richard K, Weber, Jeffrey S

Volltext

Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies von Cole, Christopher B, Russler-Germain, David A, Ketkar, Shamika, Verdoni, Angela M, Smith, Amanda M, Bangert, Celia V, Helton, Nichole M, Guo, Mindy, Klco, Jeffery M, O'Laughlin, Shelly, Fronick, Catrina, Fulton, Robert, Chang, Gue Su, Petti, Allegra A, Miller, Christopher A, Ley, Timothy J

Volltext