Vesicular dysfunction and pathways to neurodegeneration von Lewis, Patrick A

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Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment von Kluss, Jillian H., Bonet-Ponce, Luis, Lewis, Patrick A., Cookson, Mark R.

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Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies von Manzoni, Claudia, Lewis, Patrick A.

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Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study von Noyce, Alastair J, Kia, Demis A, Hemani, Gibran, Nicolas, Aude, Price, T Ryan, De Pablo-Fernandez, Eduardo, Haycock, Philip C, Lewis, Patrick A, Foltynie, Thomas, Davey Smith, George, Schrag, Anette, Lees, Andrew J, Hardy, John, Singleton, Andrew, Nalls, Mike A, Pearce, Neil, Lawlor, Debbie A, Wood, Nicholas W

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Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes von Kluss, Jillian H., Beilina, Alexandra, Williamson, Chad D., Lewis, Patrick A., Cookson, Mark R., Bonet-Ponce, Luis

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DNAJC proteins and pathways to parkinsonism von Roosen, Dorien A., Blauwendraat, Cornelis, Cookson, Mark R., Lewis, Patrick A.

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Vesicular Dysfunction and the Pathogenesis of Parkinson's Disease: Clues From Genetic Studies von Ebanks, Kirsten, Lewis, Patrick A, Bandopadhyay, Rina

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Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit von Zhao, Yibo, Vavouraki, Nikoleta, Lovering, Ruth C, Escott-Price, Valentina, Harvey, Kirsten, Lewis, Patrick A, Manzoni, Claudia

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Inhibition of LRRK2 kinase activity stimulates macroautophagy von Manzoni, Claudia, Mamais, Adamantios, Dihanich, Sybille, Abeti, Rosella, Soutar, Marc P.M., Plun-Favreau, Helene, Giunti, Paola, Tooze, Sharon A., Bandopadhyay, Rina, Lewis, Patrick A.

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LRRK2 and human disease: a complicated question or a question of complexes? von Lewis, Patrick A, Manzoni, Claudia

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Modelling the functional genomics of Parkinson's disease in Caenorhabditis elegans: LRRK2 and beyond von Chandler, Rachael J, Cogo, Susanna, Lewis, Patrick A, Kevei, Eva

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Cancer and neurodegeneration: between the devil and the deep blue sea von Plun-Favreau, Hélène, Lewis, Patrick A, Hardy, John, Martins, L Miguel, Wood, Nicholas W

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Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo von Kluss, Jillian H, Mazza, Melissa Conti, Li, Yan, Manzoni, Claudia, Lewis, Patrick A, Cookson, Mark R, Mamais, Adamantios

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase von Deng, Junpeng, Lewis, Patrick A, Greggio, Elisa, Sluch, Eli, Beilina, Alexandra, Cookson, Mark R

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mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1 von Manzoni, Claudia, Mamais, Adamantios, Roosen, Dorien A., Dihanich, Sybille, Soutar, Marc P. M., Plun-Favreau, Helene, Bandopadhyay, Rina, Hardy, John, Tooze, Sharon A., Cookson, Mark R., Lewis, Patrick A.

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Vesicle trafficking and pathways to neurodegeneration von Blackstone, Craig, Elwood, Fiona, Plun-Favreau, Helene, Lewis, Patrick A

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Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins von Cogo, Susanna, Tomkins, James E., Vavouraki, Nikoleta, Giusti, Veronica, Forcellato, Federica, Franchin, Cinzia, Tessari, Isabella, Arrigoni, Giorgio, Cendron, Laura, Manzoni, Claudia, Civiero, Laura, Lewis, Patrick A., Greggio, Elisa

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Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins von Tomkins, James E., Dihanich, Sybille, Beilina, Alexandra, Ferrari, Raffaele, Ilacqua, Nicolò, Cookson, Mark R., Lewis, Patrick A., Manzoni, Claudia

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Stratification of candidate genes for Parkinson's disease using weighted protein-protein interaction network analysis von Ferrari, Raffaele, Kia, Demis A, Tomkins, James E, Hardy, John, Wood, Nicholas W, Lovering, Ruth C, Lewis, Patrick A, Manzoni, Claudia

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis von Lewis, Patrick A., Greggio, Elisa, Beilina, Alexandra, Jain, Shushant, Baker, Acacia, Cookson, Mark R.

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