Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer von Hellmann, Matthew D., Nathanson, Tavi, Rizvi, Hira, Creelan, Benjamin C., Sanchez-Vega, Francisco, Ahuja, Arun, Ni, Ai, Novik, Jacki B., Mangarin, Levi M.B., Abu-Akeel, Mohsen, Liu, Cailian, Sauter, Jennifer L., Rekhtman, Natasha, Chang, Eliza, Callahan, Margaret K., Chaft, Jamie E., Voss, Martin H., Tenet, Megan, Li, Xue-Mei, Covello, Kelly, Renninger, Andrea, Vitazka, Patrik, Geese, William J., Borghaei, Hossein, Rudin, Charles M., Antonia, Scott J., Swanton, Charles, Hammerbacher, Jeff, Merghoub, Taha, McGranahan, Nicholas, Snyder, Alexandra, Wolchok, Jedd D.

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Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine von Campesato, Luis Felipe, Budhu, Sadna, Tchaicha, Jeremy, Weng, Chien-Huan, Gigoux, Mathieu, Cohen, Ivan Jose, Redmond, David, Mangarin, Levi, Pourpe, Stephane, Liu, Cailian, Zappasodi, Roberta, Zamarin, Dmitriy, Cavanaugh, Jill, Castro, Alfredo C., Manfredi, Mark G., McGovern, Karen, Merghoub, Taha, Wolchok, Jedd D.

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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants von Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M., Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B., Li, Yanyun, Hamadene, Linda, Flamar, Anne-Laure, Choi, Hyejin, Cortez, Czrina A., Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Betof Warner, Allison, Hollmann, Travis J., Arora, Arshi, Panageas, Katherine S., Rizzuto, Gabrielle A., Duhen, Rebekka, Weinberg, Andrew D., Spencer, Christine N., Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D., Merghoub, Taha

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Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy von Ricca, Jacob M., Oseledchyk, Anton, Walther, Tyler, Liu, Cailian, Mangarin, Levi, Merghoub, Taha, Wolchok, Jedd D., Zamarin, Dmitriy

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Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models von Verma, Svena, Budhu, Sadna, Serganova, Inna, Dong, Lauren, Mangarin, Levi M, Khan, Jonathan F, Bah, Mamadou A, Assouvie, Anais, Marouf, Yacine, Schulze, Isabell, Zappasodi, Roberta, Wolchok, Jedd D, Merghoub, Taha

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Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade von Ghosh, Arnab, Michels, Judith, Mezzadra, Riccardo, Venkatesh, Divya, Dong, Lauren, Gomez, Ricardo, Samaan, Fadi, Ho, Yu-Jui, Campesato, Luis Felipe, Mangarin, Levi, Fak, John, Suek, Nathan, Holland, Aliya, Liu, Cailian, Abu-Akeel, Mohsen, Bykov, Yonina, Zhong, Hong, Fitzgerald, Kelly, Budhu, Sadna, Chow, Andrew, Zappasodi, Roberta, Panageas, Katherine S, de Henau, Olivier, Ruscetti, Marcus, Lowe, Scott W, Merghoub, Taha, Wolchok, Jedd D

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968 PD-1hiFoxp3-CD4+ tumor-infiltrating T-cell lineage commitment impacts the immunotherapy outcome von Mangarin, Levi Mark, Martis, Stephen, Orlando, Andrea, Schad, Sara, Wolchok, Jedd D, Greenbaum, Benjamin, Merghoub, Taha, Zappasodi, Roberta

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Pilot Trial of Arginine Deprivation Plus Nivolumab and Ipilimumab in Patients with Metastatic Uveal Melanoma von Kraehenbuehl, Lukas, Holland, Aliya, Armstrong, Emma, O'Shea, Sirinya, Mangarin, Levi, Chekalil, Sara, Johnston, Amanda, Bomalaski, John S, Erinjeri, Joseph P, Barker, Christopher A, Francis, Jasmine H, Wolchok, Jedd D, Merghoub, Taha, Shoushtari, Alexander N

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1444 Pharmacologic LDH inhibition redirects intratumoral glucose consumption and improves response to CTLA-4 blockade von Verma, Svena, Zappasodi, Roberta, Budhu, Sadna, Serganova, Inna, Dong, Lauren, Mangarin, Levi Mark, Marouf, Yacine, Khan, Jonathan F, Wolchok, Jedd D, Merghoub, Taha

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Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness von Hirschhorn, Daniel, Warner, Allison Betof, Maniyar, Rachana, Chow, Andrew, Mangarin, Levi Mb, Cohen, Adam D., Hamadene, Linda, Rizzuto, Gabrielle A., Budhu, Sadna, Suek, Nathan, Liu, Cailian, Houghton, Alan N., Merghoub, Taha, Wolchok, Jedd D.

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619 Pharmacologic modulation of tumor glycolysis to improve responses to immune checkpoint blockade therapy von Verma, Svena, Maniyar, Rachana, Ko, Myat, Budhu, Sadna, Serganova, Inna, Zappasodi, Roberta, Blasberg, Ronald, Merghoub, Taha, Wolchok, Jedd, Mangarin, Levi

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493 Tired and hungry: a potential role for CD47 in T cell exhaustion von Mangarin, Levi, Liu, Cailian, Zappasodi, Roberta, Holland, Pamela, Wolchok, Jedd, Merghoub, Taha, Weng, Chien-Huan, Schroder, David

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549 Characterizing double positive T cells in the tumor microenvironment: a tale of promiscuous cell fates von Schad, Sara, Chow, Andrew, Pan, Heng, Mangarin, Levi, Zappasodi, Roberta, Gigoux, Mathieu, Redmond, David, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Elemento, Olivier, Wolchok, Jedd, Merghoub, Taha

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99 T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants von Hirschhorn, Daniel, Budhu, Sadna, Schröder, David, kraehenbuehl, Lukas, Flammar, Anne-Laurent, Chow, Andrew, Schulze, Isabell, Schad, Sara, Ricca, Jacob, Gasmi, Billel, Henau, Olivier De, Mangarin, Levi, Redmond, David, Cortez, Czrina, Liu, Cailian, Holland, Aliya, Gigoux, Mathieu, Arora, Asrhi, Panageas, Katherine, Rizzuto, Gabrielle, Albrengues, Jean, Egeblad, Mikala, Wolchok, Jedd, Merghoub, Taha

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444 MHC-I skewing in mutant calreticulin-positive myeloproliferative neoplasms is countered by heteroclitic peptide cancer vaccination von Gigoux, Mathieu, Zappasodi, Roberta, Park, Joseph, Pourpe, Stephane, Ghosh, Arnab, Bozkus, Cansu Cimen, Mangarin, Levi, Redmond, David, Verma, Svena, Schad, Sara, Duke, William, Jan, Max, Leventhal, Matthew, Ho, Vincent, Hobbs, Gabriela, Knudsen, Trine Alma, Skov, Vibe, Kjær, Lasse, Larsen, Thomas Stauffer, Hansen, Dennis Lund, Coleman Lindsley, R, Hasselbalch, Hans, Grauslund, Jacob, Andersen, Mads, Holmström, Morten, Chan, Timothy, Rampal, Raajit, Abdel-Wahab, Omar, Bhardwaj, Nina, Wolchok, Jedd, Mullally, Ann, Merghoub, Taha

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878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants von Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Flamar, Anne-Laure, Choi, Heyjin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Hamadene, Linda, Warner, Allison Betof, Hollmann, Travis, Arora, Arshi, Panageas, Katherine S, Duhen, Rebekka, Weinberg, Andrew D, Rizzuto, Gabrielle A, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha

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The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer von Chow, Andrew, Uddin, Fathema Z., Liu, Michael, Dobrin, Anton, Nabet, Barzin Y., Mangarin, Levi, Lavin, Yonit, Rizvi, Hira, Tischfield, Sam E., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Shah, Nisargbhai, Allaj, Viola, Manoj, Parvathy, Mattar, Marissa, Meneses, Maximiliano, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Egger, Jacklynn, Chavan, Shweta S., Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn, Daniel, Guan, Xiangnan, Richards, Allison L., Heller, Glenn, Mansilla-Soto, Jorge, Sadelain, Michel, Klebanoff, Christopher A., Hellmann, Matthew D., Sen, Triparna, de Stanchina, Elisa, Wolchok, Jedd D., Merghoub, Taha, Rudin, Charles M.

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Abstract 1795: Combination of cyclophosphamide chemotherapy with immune modulation overcomes resistance to checkpoint blockade in a pre-clinical melanoma model von Warner, Allison Betof, Hirschhorn, Daniel, Mangarin, Levi M., Hamadene, Linda, Cohen, Adam D., Rizzuto, Gabrielle A., Wolchok, Jedd D., Merghoub, Taha

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Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions von Schad, Sara E, Chow, Andrew, Mangarin, Levi, Pan, Heng, Zhang, Jiajia, Ceglia, Nicholas, Caushi, Justina X, Malandro, Nicole, Zappasodi, Roberta, Gigoux, Mathieu, Hirschhorn, Daniel, Budhu, Sadna, Amisaki, Masataka, Arniella, Monica, Redmond, David, Chaft, Jamie, Forde, Patrick M, Gainor, Justin F, Hellmann, Matthew D, Balachandran, Vinod, Shah, Sohrab, Smith, Kellie N, Pardoll, Drew, Elemento, Olivier, Wolchok, Jedd D, Merghoub, Taha

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Abstract 5873: LDH inhibition boosts effector T cells while destabilizing regulatory T cells and improves responses to CTLA-4 blockade von Verma, Svena, Serganova, Inna, Dong, Lauren, Budhu, Sadna, Mangarin, Levi, Zappasodi, Roberta, Merghoub, Taha, Wolchok, Jedd D.

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