Targeting ErbB3 and Cellular NADPH/NADP+ Abundance Sensitizes Cutaneous Melanomas to Ferroptosis Inducers von I-Ju Leu, Julia, Murphy, Maureen E., George, Donna L.

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The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction von Kung, Che-Pei, Leu, Julia I-Ju, Basu, Subhasree, Khaku, Sakina, Anokye-Danso, Frederick, Liu, Qin, George, Donna L., Ahima, Rexford S., Murphy, Maureen E.

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A modified HSP70 inhibitor shows broad activity as an anticancer agent von Balaburski, Gregor M, Leu, Julia I-Ju, Beeharry, Neil, Hayik, Seth, Andrake, Mark D, Zhang, Gao, Herlyn, Meenhard, Villanueva, Jessie, Dunbrack, Jr, Roland L, Yen, Tim, George, Donna L, Murphy, Maureen E

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Tailoring Chemotherapy for the African-Centric S47 Variant of TP53 von Barnoud, Thibaut, Budina-Kolomets, Anna, Basu, Subhasree, Leu, Julia I-Ju, Good, Madeline, Kung, Che-Pei, Liu, Jingjing, Liu, Qin, Villanueva, Jessie, Zhang, Rugang, George, Donna L, Murphy, Maureen E

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HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma von Parris, Joshua L D, Barnoud, Thibaut, Leu, Julia I-Ju, Leung, Jessica C, Ma, Weili, Kirven, Nicole A, Poli, Adi Naryana Reddy, Kossenkov, Andrew V, Liu, Qin, Salvino, Joseph M, George, Donna L, Weeraratna, Ashani T, Chen, Qing, Murphy, Maureen E

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Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53 von Leu, Julia I-Ju, Murphy, Maureen E., George, Donna L.

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Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBPβ and Mitogen-Activated Protein Kinas... von Leu, Julia I., Crissey, Mary Ann S., Craig, Linden E., Taub, Rebecca

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An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model von Jennis, Matthew, Kung, Che-Pei, Basu, Subhasree, Budina-Kolomets, Anna, Leu, Julia I-Ju, Khaku, Sakina, Scott, Jeremy P, Cai, Kathy Q, Campbell, Michelle R, Porter, Devin K, Wang, Xuting, Bell, Douglas A, Li, Xiaoxian, Garlick, David S, Liu, Qin, Hollstein, Monica, George, Donna L, Murphy, Maureen E

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Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate von Zhang, Pingfeng, Leu, Julia I-Ju, Murphy, Maureen E, George, Donna L, Marmorstein, Ronen

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African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin von Singh, Kumar Sachin, Leu, Julia I-Ju, Barnoud, Thibaut, Vonteddu, Prashanthi, Gnanapradeepan, Keerthana, Lin, Cindy, Liu, Qin, Barton, James C., Kossenkov, Andrew V., George, Donna L., Murphy, Maureen E., Dotiwala, Farokh

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Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C‑Terminal Allosteric Pocket von Leu, Julia I-Ju, Zhang, Pingfeng, Murphy, Maureen E., Marmorstein, Ronen, George, Donna L.

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A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors von Barnoud, Thibaut, Leung, Jessica C, Leu, Julia I-Ju, Basu, Subhasree, Poli, Adi Narayana Reddy, Parris, Joshua L D, Indeglia, Alexandra, Martynyuk, Tetyana, Good, Madeline, Gnanapradeepan, Keerthana, Sanseviero, Emilio, Moeller, Rebecca, Tang, Hsin-Yao, Cassel, Joel, Kossenkov, Andrew V, Liu, Qin, Speicher, David W, Gabrilovich, Dmitry I, Salvino, Joseph M, George, Donna L, Murphy, Maureen E

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An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression von Indeglia, Alexandra, Leung, Jessica C, Miller, Sven A, Leu, Julia I-Ju, Dougherty, James F, Clarke, Nicole L, Kirven, Nicole A, Shao, Chunlei, Ke, Lei, Lovell, Scott, Barnoud, Thibaut, Lu, David Y, Lin, Cindy, Kannan, Toshitha, Battaile, Kevin P, Yang, Tyler Hong Loong, Batista Oliva, Isabela, Claiborne, Daniel T, Vogel, Peter, Liu, Lijun, Liu, Qin, Nefedova, Yulia, Cassel, Joel, Auslander, Noam, Kossenkov, Andrew V, Karanicolas, John, Murphy, Maureen E

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The Codon 72 Polymorphism of p53 Regulates Interaction with NF-κB and Transactivation of Genes Involved in Immunity and Inflammation von Frank, Amanda K., Leu, Julia I-Ju, Zhou, Yan, Devarajan, Karthik, Nedelko, Tatiana, Klein-Szanto, Andres, Hollstein, Monica, Murphy, Maureen E.

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Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function von Leu, Julia I-Ju, Barnoud, Thibaut, Zhang, Gao, Tian, Tian, Wei, Zhi, Herlyn, Meenhard, Murphy, Maureen E, George, Donna L

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser von Gnanapradeepan, Keerthana, Leu, Julia I-Ju, Basu, Subhasree, Barnoud, Thibaut, Good, Madeline, Lee, Joyce V, Quinn, William J, Kung, Che-Pei, Ahima, Rexford, Baur, Joseph A, Wellen, Kathryn E, Liu, Qin, Schug, Zachary T, George, Donna L, Murphy, Maureen E

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Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin von Singh, Kumar Sachin, Leu, Julia I-Ju, Barnoud, Thibaut, Vonteddu, Prashanthi, Gnanapradeepan, Keerthana, Lin, Cindy, Liu, Qin, Barton, James C., Kossenkov, Andrew V., George, Donna L., Murphy, Maureen E., Dotiwala, Farokh

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Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury von Leu, Julia I., Crissey, Mary Ann S., Leu, James P., Ciliberto, Gennaro, Taub, Rebecca

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P53 regulates cellular redox state, ferroptosis and metabolism von Leu, Julia I-Ju, Murphy, Maureen E., George, Donna L.

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Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration von Macias-Silva, Marina, Li, Wei, Leu, Julia I, Crissey, Mary Ann S, Taub, Rebecca

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