Bruton’s tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia von Deng, J, Isik, E, Fernandes, S M, Brown, J R, Letai, A, Davids, M S

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Mimicking the BH3 domain to kill cancer cells von Chonghaile, T Ni, Letai, A

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Pharmacological manipulation of Bcl-2 family members to control cell death von Letai, Anthony

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BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics von Touzeau, C, Ryan, J, Guerriero, J, Moreau, P, Chonghaile, T N, Le Gouill, S, Richardson, P, Anderson, K, Amiot, M, Letai, A

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p53 regulates a non-apoptotic death induced by ROS von Montero, J, Dutta, C, van Bodegom, D, Weinstock, D, Letai, A

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Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells von Kutuk, O, Letai, A

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Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells von Colak, S, Zimberlin, C D, Fessler, E, Hogdal, L, Prasetyanti, P R, Grandela, C M, Letai, A, Medema, J P

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib von Chauhan, Dharminder, Catley, Laurence, Li, Guilan, Podar, Klaus, Hideshima, Teru, Velankar, Mugdha, Mitsiades, Constantine, Mitsiades, Nicolas, Yasui, Hiroshi, Letai, Anthony, Ovaa, Huib, Berkers, Celia, Nicholson, Benjamin, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Richardson, Paul, Palladino, Michael A., Anderson, Kenneth C.

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Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice von Etchin, J, Montero, J, Berezovskaya, A, Le, B T, Kentsis, A, Christie, A L, Conway, A S, Chen, W C, Reed, C, Mansour, M R, Ng, C E L, Adamia, S, Rodig, S J, Galinsky, I A, Stone, R M, Klebanov, B, Landesman, Y, Kauffman, M, Shacham, S, Kung, A L, Wang, J C Y, Letai, A, Look, A T

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Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release von Berger, Alison K., Cortese, Giuseppe P., Amodeo, Katherine D., Weihofen, Andreas, Letai, Anthony, LaVoie, Matthew J.

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BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2 von Flanagan, A M, Letai, A

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Bcl-xL controls a switch between cell death modes during mitotic arrest von Bah, N, Maillet, L, Ryan, J, Dubreil, S, Gautier, F, Letai, A, Juin, P, Barillé-Nion, S

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Mitochondria—Judges and Executioners of Cell Death Sentences von Bhola, Patrick D., Letai, Anthony

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Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis von Murphy, Á. C., Weyhenmeyer, B., Noonan, J., Kilbride, S. M., Schimansky, S., Loh, K. P., Kögel, D., Letai, A. G., Prehn, J. H. M., Murphy, B. M.

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BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals von Jette, C A, Flanagan, A M, Ryan, J, Pyati, U J, Carbonneau, S, Stewart, R A, Langenau, D M, Look, A T, Letai, A

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The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance von Barbone, D, Ryan, J A, Kolhatkar, N, Chacko, A D, Jablons, D M, Sugarbaker, D J, Bueno, R, Letai, A G, Coussens, L M, Fennell, D A, Broaddus, V C

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P310: BH3 PROFILING IDENTIFIES SELECTIVE BCL‐2 DEPENDENCE OF ADULT EARLY T‐CCELL PROGENITOR AND TYPICAL ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS von Bhatia, K., Mahesh, A., Olesinski, E., Garcia, J., Jain, N., Jen, W. Y., Ooi Gaik Ming, M., Letai, A., Konopleva, M., Bhatt, S.

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715: BCL-2 dependence in T-cell leukemia is defined by the maturation stage of the clone of origin von Ni Chonghaile, T, Roderick, J, Gutierrez, G, Kelliher, M, Letai, A

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427 The mitochondrial basis of resistance to BCL-2 antagonists and conventional chemotherapy von Letai, A, Kutuk, O, Vo, T, Ryan, J, Deng, J, Sarosiek, K, Chonghaile, T. Ni

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Bcl-xL controls a switch between cell death modes during mitotic arrest von Bah, N, Maillet, L, Ryan, J, Dubreil, S, Gautier, F, Letai, A, Juin, P, Barillé-nion, S

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