Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation von Tanaka, Noritaka, Lin, Jessica J., Li, Chendi, Ryan, Meagan B., Zhang, Junbing, Kiedrowski, Lesli A., Michel, Alexa G., Syed, Mohammed U., Fella, Katerina A., Sakhi, Mustafa, Baiev, Islam, Juric, Dejan, Gainor, Justin F., Klempner, Samuel J., Lennerz, Jochen K., Siravegna, Giulia, Bar-Peled, Liron, Hata, Aaron N., Heist, Rebecca S., Corcoran, Ryan B.

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Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based Methodologies von Odegaard, Justin I, Vincent, John J, Mortimer, Stefanie, Vowles, James V, Ulrich, Bryan C, Banks, Kimberly C, Fairclough, Stephen R, Zill, Oliver A, Sikora, Marcin, Mokhtari, Reza, Abdueva, Diana, Nagy, Rebecca J, Lee, Christine E, Kiedrowski, Lesli A, Paweletz, Cloud P, Eltoukhy, Helmy, Lanman, Richard B, Chudova, Darya I, Talasaz, AmirAli

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Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma von Maron, Steven B, Chase, Leah M, Lomnicki, Samantha, Kochanny, Sara, Moore, Kelly L, Joshi, Smita S, Landron, Stacie, Johnson, Julie, Kiedrowski, Lesli A, Nagy, Rebecca J, Lanman, Richard B, Kim, Seung Tae, Lee, Jeeyun, Catenacci, Daniel V T

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Response to Dual Crizotinib and Osimertinib Treatment in a Lung Cancer Patient with MET Amplification Detected by Liquid Biopsy Who Acquired Secondary Resistance to EGFR Tyrosine K... von Deng, Lei, Kiedrowski, Lesli A., Ravera, Elizabeth, Cheng, Haiying, Halmos, Balazs

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Molecular heterogeneity and co-altered genes in MET-amplified ALK-positive lung cancer: Implications for MET targeted therapy von Dagogo-Jack, Ibiayi, Kiedrowski, Lesli A., Lennerz, Jochen K.

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Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA von Agarwal, Neeraj, Pal, Sumanta K., Hahn, Andrew W., Nussenzveig, Roberto H., Pond, Gregory R., Gupta, Sumati V., Wang, Jue, Bilen, Mehmet A., Naik, Gurudatta, Ghatalia, Pooja, Hoimes, Christopher J., Gopalakrishnan, Dharmesh, Barata, Pedro C., Drakaki, Alexandra, Faltas, Bishoy M., Kiedrowski, Lesli A., Lanman, Richard B., Nagy, Rebecca J., Vogelzang, Nicholas J., Boucher, Kenneth M., Vaishampayan, Ulka N., Sonpavde, Guru, Grivas, Petros

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Analysis of cell-free circulating tumor DNA in 419 patients with glioblastoma and other primary brain tumors von Piccioni, David E, Achrol, Achal Singh, Kiedrowski, Lesli A, Banks, Kimberly C, Boucher, Najee, Barkhoudarian, Garni, Kelly, Daniel F, Juarez, Tiffany, Lanman, Richard B, Raymond, Victoria M, Nguyen, Minhdan, Truong, Judy D, Heng, Annie, Gill, Jaya, Saria, Marlon, Pingle, Sandeep C, Kesari, Santosh

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Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers von Kobayashi, Yoshihisa, Chhoeu, Chhayheng, Li, Jiaqi, Price, Kristin S., Kiedrowski, Lesli A., Hutchins, Jamie L., Hardin, Aaron I., Wei, Zihan, Hong, Fangxin, Bahcall, Magda, Gokhale, Prafulla C., Jänne, Pasi A.

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The Clinical Implications of Reversions in Patients with Advanced Pancreatic Cancer and Pathogenic Variants in BRCA1, BRCA2, or PALB2 after Progression on Rucaparib von Brown, Timothy J, Yablonovitch, Arielle, Till, Jacob E, Yen, Jennifer, Kiedrowski, Lesli A, Hood, Ryan, O'Hara, Mark H, Teitelbaum, Ursina, Karasic, Thomas B, Schneider, Charles, Carpenter, Erica L, Nathanson, Katherine, Domchek, Susan M, Reiss, Kim A

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Clinical activity of pembrolizumab in metastatic prostate cancer with microsatellite instability high (MSI-H) detected by circulating tumor DNA von Barata, Pedro, Agarwal, Neeraj, Nussenzveig, Roberto, Gerendash, Benjamin, Jaeger, Ellen, Hatton, Whitley, Ledet, Elisa, Lewis, Brian, Layton, Jodi, Babiker, Hani, Bryce, Alan, Garje, Rohan, Stein, Cy, Kiedrowski, Lesli, Saylor, Philip, Sartor, Oliver

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NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types von Rolfo, Christian, Drilon, Alexander, Hong, David, McCoach, Caroline, Dowlati, Afshin, Lin, Jessica J., Russo, Alessandro, Schram, Alison M., Liu, Stephen V., Nieva, Jorge J., Nguyen, Timmy, Eshaghian, Shahrooz, Morse, Michael, Gettinger, Scott, Mobayed, Mohammad, Goldberg, Sarah, Araujo-Mino, Emilio, Vidula, Neelima, Bardia, Aditya, Subramanian, Janakiraman, Sashital, Deepa, Stinchcombe, Thomas, Kiedrowski, Lesli, Price, Kristin, Gandara, David R.

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Locally Recurrent Secretory Carcinoma of the Breast with NTRK3 Gene Fusion von Mortensen, Lindsey, Ordulu, Zehra, Dagogo‐Jack, Ibiayi, Bossuyt, Veerle, Winters, Loren, Taghian, Alphonse, Smith, Barbara L., Ellisen, Leif W., Kiedrowski, Lesli A., Lennerz, Jochen K., Bardia, Aditya, Spring, Laura M.

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Olaparib in hormone receptor-positive, HER2-negative metastatic breast cancer with a somatic BRCA2 mutation von Schwartzberg, Lee S., Kiedrowski, Lesli A.

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The economic value of liquid biopsy for genomic profiling in advanced non-small cell lung cancer von Ezeife, Doreen A., Spackman, Eldon, Juergens, Rosalyn A., Laskin, Janessa J., Agulnik, Jason S., Hao, Desiree, Laurie, Scott A., Law, Jennifer H., Le, Lisa W., Kiedrowski, Lesli A., Melosky, Barbara, Shepherd, Frances A., Cohen, Victor, Wheatley-Price, Paul, Vandermeer, Rachel, Li, Janice J., Fernandes, Roxanne, Shokoohi, Aria, Lanman, Richard B., Leighl, Natasha B.

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The dynamic landscape of BRCA1 reversion mutations from indel to SNV in a patient with ovarian cancer treated with PARP-inhibitors and immunotherapy von Jacob, Saya L., Kiedrowski, Lesli A., Chae, Young K.

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Parents’ Perspectives on Variants of Uncertain Significance from Chromosome Microarray Analysis von Kiedrowski, Lesli A., Owens, Kailey M., Yashar, Beverly M., Schuette, Jane L.

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Genomic landscape of advanced prostate cancer patients with BRCA1 versus BRCA2 mutations as detected by comprehensive genomic profiling of cell-free DNA von Swami, Umang, Zimmerman, Raquel Mae, Nussenzveig, Roberto H, Hernandez, Edgar Javier, Jo, Yeonjung, Sayegh, Nicolas, Wesolowski, Sergiusz, Kiedrowski, Lesli A, Barata, Pedro C, Lemmon, Gordon Howard, Bilen, Mehmet A, Heath, Elisabeth I, Nandagopal, Lakshminarayan, Babiker, Hani M, Pal, Sumanta K, Lilly, Michael, Maughan, Benjamin L, Haaland, Benjamin, Yandell, Mark, Sartor, Oliver, Agarwal, Neeraj

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Efficacy and Tolerability of ALK/MET Combinations in Patients With ALK-Rearranged Lung Cancer With Acquired MET Amplification: A Retrospective Analysis von Dagogo-Jack, Ibiayi, Kiedrowski, Lesli A., Heist, Rebecca S., Lin, Jessica J., Meador, Catherine B., Krueger, Elizabeth A., Do, Andrew, Peterson, Jennifer, Sequist, Lecia V., Gainor, Justin F., Lennerz, Jochen K., Digumarthy, Subba R.

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Use of on-therapy ctDNA monitoring in a patient with KIF5B-RET fusion positive advanced non-small cell lung cancer: a case report von Yeung, Vincent, Kim, Chul, Kiedrowski, Lesli A., Liu, Stephen V., Reuss, Joshua E.

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Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer von Shiba-Ishii, Aya, Johnson, Ted W, Dagogo-Jack, Ibiayi, Mino-Kenudson, Mari, Johnson, Theodore R, Wei, Ping, Weinrich, Scott L, McTigue, Michele A, Walcott, Makeba A, Nguyen-Phuong, Linh, Dionne, Kristin, Acker, Adam, Kiedrowski, Lesli A, Do, Andrew, Peterson, Jennifer L, Barth, Jaimie L, Yeap, Beow Y, Gainor, Justin F, Lin, Jessica J, Yoda, Satoshi, Hata, Aaron N

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