IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress von Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R.

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Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits von Acosta-Alvear, Diego, Cho, Min Y, Wild, Thomas, Buchholz, Tonia J, Lerner, Alana G, Simakova, Olga, Hahn, Jamie, Korde, Neha, Landgren, Ola, Maric, Irina, Choudhary, Chunaram, Walter, Peter, Weissman, Jonathan S, Kampmann, Martin

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Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism von Spatola, Bradley N., Lerner, Alana G., Wong, Clifford, dela Cruz, Tracy, Welch, Megan, Fung, Wanchi, Kovalenko, Maria, Losenkova, Karolina, Yegutkin, Gennady G., Beers, Courtney, Corbin, John, Soros, Vanessa B.

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Flagellar Motility Contributes to Cytokinesis in Trypanosoma brucei and Is Modulated by an Evolutionarily Conserved Dynein Regulatory System von Ralston, Katherine S, Lerner, Alana G, Diener, Dennis R, Hill, Kent L

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Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity von Li, Xian-Yang, Moesta, Achim K, Xiao, Christos, Nakamura, Kyohei, Casey, Mika, Zhang, Haiyan, Madore, Jason, Lepletier, Ailin, Aguilera, Amelia Roman, Sundarrajan, Ashmitha, Jacoberger-Foissac, Celia, Wong, Clifford, Dela Cruz, Tracy, Welch, Megan, Lerner, Alana G, Spatola, Bradley N, Soros, Vanessa B, Corbin, John, Anderson, Ana C, Effern, Maike, Hölzel, Michael, Robson, Simon C, Johnston, Rebecca L, Waddell, Nicola, Smith, Corey, Bald, Tobias, Geetha, Nishamol, Beers, Courtney, Teng, Michele W L, Smyth, Mark J

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IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates von Han, Dan, Lerner, Alana G., Vande Walle, Lieselotte, Upton, John-Paul, Xu, Weihong, Hagen, Andrew, Backes, Bradley J., Oakes, Scott A., Papa, Feroz R.

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Abstract 1735: Identification of novel synthetic lethal interactions in small cell lung cancer with the proteasome inhibitor carfilzomib von Masto, Vincent B., Lerner, Alana G., Arastu-Kapur, Shirin

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Abstract 5012: Targeting CD39 with a first-in-class inhibitory antibody prevents ATP processing and increases T-cell activation von Lerner, Alana G., Kovalenko, Maria, Welch, Megan, Cruz, Tracy dela, Jones, Jeff, Wong, Clifford, Spatola, Bradley, Eberhardt, Meghan, Wong, Andrew, Fung, Wanchi, Lagpacan, Leanna, Losenkova, Karolina, Yegutkin, Gennady, Soros, Vanessa, Corbin, John, Beers, Courtney, Moesta, Achim K.

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Type 2 diabetes and cardiac autonomic neuropathy screening using dynamic pupillometry von Lerner, A. G., Bernabé-Ortiz, A., Ticse, R., Hernandez, A., Huaylinos, Y., Pinto, M. E., Málaga, G., Checkley, W., Gilman, R. H., Miranda, J. J.

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IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death during endoplasmic reticulum stress von Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R.

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IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates von Han, Dan, Lerner, Alana G, Vande Walle, Lieselotte, Upton, John-Paul, Xu, Weihong, Hagen, Andrew, Backes, Bradley J, Oakes, Scott A, Papa, Feroz R

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Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism von Spatola, Bradley N., Lerner, Alana G., Wong, Clifford, dela Cruz, Tracy, Welch, Megan, Fung, Wanchi, Kovalenko, Maria, Losenkova, Karolina, Yegutkin, Gennady G., Beers, Courtney, Corbin, John, Soros, Vanessa B.

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