Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia von Holdstock, Louis, Meadowcroft, Amy M, Maier, Rayma, Johnson, Brendan M, Jones, Delyth, Rastogi, Anjay, Zeig, Steven, Lepore, John J, Cobitz, Alexander R

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Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart von Aravindhan, Karpagam, Bao, Weike, Harpel, Mark R, Willette, Robert N, Lepore, John J, Jucker, Beat M

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Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy von Seo, Kinya, Rainer, Peter P., Hahn, Virginia Shalkey, Lee, Dong-ik, Jo, Su-Hyun, Andersen, Asger, Liu, Ting, Xu, Xiaoping, Willette, Robert N., Lepore, John J., Marino, Joseph P., Birnbaumer, Lutz, Schnackenberg, Christine G., Kass, David A.

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Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype von Ivashchenko, Christine Y, Pipes, Gordon C, Lozinskaya, Irina M, Lin, Zuojun, Xiaoping, Xu, Needle, Saul, Grygielko, Eugene T, Hu, Erding, Toomey, John R, Lepore, John J, Willette, Robert N

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Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial von Newby, L Kristin, Prof, Marber, Michael S, Prof, Melloni, Chiara, MD, Sarov-Blat, Lea, PhD, Aberle, Laura H, BSPH, Aylward, Philip E, Prof, Cai, Gengqian, PhD, de Winter, Robbert J, Prof, Hamm, Christian W, Prof, Heitner, John F, MD, Kim, Raymond, Prof, Lerman, Amir, MD, Patel, Manesh R, MD, Tanguay, Jean-Francois, Prof, Lepore, John J, MD, Al-Khalidi, Hussein R, PhD, Sprecher, Dennis L, MD, Granger, Christopher B, Prof

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Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial von O’Donoghue, Michelle L, Glaser, Ruchira, Cavender, Matthew A, Aylward, Philip E, Bonaca, Marc P, Budaj, Andrzej, Davies, Richard Y, Dellborg, Mikael, Fox, Keith A. A, Gutierrez, Jorge Antonio T, Hamm, Christian, Kiss, Robert G, Kovar, František, Kuder, Julia F, Im, Kyung Ah, Lepore, John J, Lopez-Sendon, Jose L, Ophuis, Ton Oude, Parkhomenko, Alexandr, Shannon, Jennifer B, Spinar, Jindrich, Tanguay, Jean-Francois, Ruda, Mikhail, Steg, P. Gabriel, Theroux, Pierre, Wiviott, Stephen D, Laws, Ian, Sabatine, Marc S, Morrow, David A

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Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and Reduced Eject... von Lepore, John J., MD, Olson, Eric, PhD, Demopoulos, Laura, MD, Haws, Thomas, BS, Fang, Zixing, PhD, Barbour, April M., PhD, Fossler, Michael, PharmD, PhD, Davila-Roman, Victor G., MD, Russell, Stuart D., MD, Gropler, Robert J., MD

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A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration von DeMayo, Francesco J, Yang, Jifu, Zhang, Yuzhen, Morrisey, Edward E, Cohen, Ethan David, Whitsett, Jeffrey A, Goss, Ashley M, Kadzik, Rachel, Parmacek, Michael S, Lepore, John J, Muthukumaraswamy, Karthika

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Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants with chronic kidney disease von Holdstock, Louis, Cizman, Borut, Meadowcroft, Amy M, Biswas, Nandita, Johnson, Brendan M, Jones, Delyth, Kim, Sung Gyun, Zeig, Steven, Lepore, John J, Cobitz, Alexander R

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Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis von Meadowcroft, Amy M, Cizman, Borut, Holdstock, Louis, Biswas, Nandita, Johnson, Brendan M, Jones, Delyth, Nossuli, A Kaldun, Lepore, John J, Aarup, Michael, Cobitz, Alexander R

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Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects von Akizawa, Tadao, Tsubakihara, Yoshiharu, Nangaku, Masaomi, Endo, Yukihiro, Nakajima, Hiromu, Kohno, Tomoko, Imai, Yukiko, Kawase, Natsumi, Hara, Katsutoshi, Lepore, John, Cobitz, Alexander

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Impaired notch signaling promotes de novo squamous cell carcinoma formation von Proweller, Aaron, Tu, Lili, Lepore, John J, Cheng, Lan, Lu, Min Min, Seykora, John, Millar, Sarah E, Pear, Warren S, Parmacek, Michael S

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Characterization and In Vivo Pharmacological Rescue of a Wnt2-Gata6 Pathway Required for Cardiac Inflow Tract Development von Tian, Ying, Yuan, Lijun, Goss, Ashley M., Wang, Tao, Yang, Jifu, Lepore, John J., Zhou, Diane, Schwartz, Robert J., Patel, Vickas, Cohen, Ethan David, Morrisey, Edward E.

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Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling von Cohen, Ethan David, Wang, Zhishan, Lepore, John J, Lu, Min Min, Taketo, Makoto M, Epstein, Douglas J, Morrisey, Edward E

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Effects of p38 Mitogen-Activated Protein Kinase Inhibition on Vascular and Systemic Inflammation in Patients With Atherosclerosis von Elkhawad, Maysoon, MBBChir, MA, Rudd, James H.F., MBChB, PhD, Sarov-Blat, Lea, PhD, Cai, Gengqian, PhD, Wells, Richard, BA, Davies, L. Ceri, MD, MBBS, Collier, David J., PhD, MBBS, Marber, Michael S., MBBS, PhD, Choudhury, Robin P., BMBCh, MA, DM, Fayad, Zahi A., PhD, Tawakol, Ahmed, MD, Gleeson, Fergus V., MBBS, Lepore, John J., MD, Davis, Bill, PhD, Willette, Robert N., PhD, Wilkinson, Ian B., BMBCh, DM, Sprecher, Dennis L., MD, Cheriyan, Joseph, MBChB

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Ephrin-B2 controls PDGFRβ internalization and signaling von Nakayama, Akiko, Nakayama, Masanori, Turner, Christopher J, Höing, Susanne, Lepore, John J, Adams, Ralf H

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Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials von Shaddinger, Bonnie C, Xu, Yanmei, Roger, James H, Macphee, Colin H, Handel, Malcolm, Baidoo, Charlotte A, Magee, Mindy, Lepore, John J, Sprecher, Dennis L

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The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits von Zhou, Jin, Li, Jie, Rosenbaum, Daniel M, Zhuang, Jian, Poon, Carrie, Qin, Pu, Rivera, Katrina, Lepore, John, Willette, Robert N, Hu, Erding, Barone, Frank C

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Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure von LEWIS, Gregory D, LACHMANN, Justine, CAMUSO, Janice, LEPORE, John J, SHIN, Jordan, MARTINOVIC, Maryann E, SYSTROM, David M, BLOCH, Kenneth D, SEMIGRAN, Marc J

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Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop von Kook, Hyun, Lepore, John J, Gitler, Aaron D, Lu, Min Min, Wing-Man Yung, Wendy, Mackay, Joel, Zhou, Rong, Ferrari, Victor, Gruber, Peter, Epstein, Jonathan A

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