MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice von Collins, Meredith A, Yan, Wei, Sebolt–Leopold, Judith S, Pasca di Magliano, Marina

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Targeting the mitogen-activated protein kinase cascade to treat cancer von Sebolt-Leopold, Judith S., Herrera, Roman

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Advances in the Development of Cancer Therapeutics Directed against the RAS-Mitogen-Activated Protein Kinase Pathway von Judith S. Sebolt-Leopold

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Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1 von Zhang, Huabing, Ramakrishnan, Sadeesh K, Triner, Daniel, Centofanti, Brook, Maitra, Dhiman, Győrffy, Balázs, Sebolt-Leopold, Judith S, Dame, Michael K, Varani, James, Brenner, Dean E, Fearon, Eric R, Omary, M Bishr, Shah, Yatrik M

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Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor von Ramkumar, Kavya, Samanta, Soma, Kyani, Anahita, Yang, Suhui, Tamura, Shuzo, Ziemke, Elizabeth, Stuckey, Jeanne A., Li, Si, Chinnaswamy, Krishnapriya, Otake, Hiroyuki, Debnath, Bikash, Yarovenko, Vladimir, Sebolt-Leopold, Judith S., Ljungman, Mats, Neamati, Nouri

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Cancer stem cell marker phenotypes are reversible and functionally homogeneous in a preclinical model of pancreatic cancer von Dosch, Joseph S, Ziemke, Elizabeth K, Shettigar, Amrith, Rehemtulla, Alnawaz, Sebolt-Leopold, Judith S

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Multicenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer von RINEHART, John, ADJEI, Alex A, GULYAS, Stephen, MITCHELL, David Y, HERRERA, Roman, SEBOLT-LEOPOLD, Judith S, MEYER, Mark B, LORUSSO, Patricia M, WATERHOUSE, David, HECHT, J. Randolph, NATALE, Ronald B, HAMID, Oday, VARTERASIAN, Mary, ASBURY, Peggy, KALDJIAN, Eric P

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Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers von Maust, Joel D, Frankowski-McGregor, Christy L, Bankhead, 3rd, Armand, Simeone, Diane M, Sebolt-Leopold, Judith S

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One Step at a Time — Clinical Evidence That KRAS Is Indeed Druggable von LoRusso, Patricia M, Sebolt-Leopold, Judith S

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DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma von Galbán, Stefanie, Lemasson, Benjamin, Williams, Terence M, Li, Fei, Heist, Kevin A, Johnson, Timothy D, Leopold, Judith S, Chenevert, Thomas L, Lawrence, Theodore S, Rehemtulla, Alnawaz, Mikkelsen, Tom, Holland, Eric C, Galbán, Craig J, Ross, Brian D

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Mechanisms of drug inhibition of signalling molecules von Sebolt-Leopold, Judith S., English, Jessie M.

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Deciphering the Complexity of MEK Mutations in the Clinic von Whitehead, Christopher E, Sebolt-Leopold, Judith S

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ERK activation is required for CCK-mediated pancreatic adaptive growth in mice von Holtz, Bryan J, Lodewyk, Kevin B, Sebolt-Leopold, Judith S, Ernst, Stephen A, Williams, John A

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Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition von Abecunas, Cara, Whitehead, Christopher E, Ziemke, Elizabeth K, Baumann, Douglas G, Frankowski-McGregor, Christy L, Sebolt-Leopold, Judith S, Fallahi-Sichani, Mohammad

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Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6 von Ziemke, Elizabeth K, Dosch, Joseph S, Maust, Joel D, Shettigar, Amrith, Sen, Ananda, Welling, Theodore H, Hardiman, Karin M, Sebolt-Leopold, Judith S

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Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence von Sharma, Monika, Barravecchia, Ivana, Teis, Robert, Cruz, Jeanette, Mumby, Rachel, Ziemke, Elizabeth K, Espinoza, Carlos E, Krishnamoorthy, Varunkumar, Magnuson, Brian, Ljungman, Mats, Koschmann, Carl, Chandra, Joya, Whitehead, Christopher E, Sebolt-Leopold, Judith S, Galban, Stefanie

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Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological intervention von Herrera, Roman, Sebolt-Leopold, Judith S.

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Development of Preclinical Models to Understand and Treat Colorectal Cancer von Sebolt-Leopold, Judith S.

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Oncogenic Mutants of MEK1 : A Trilogy Unfolds von Maust, Joel D, Whitehead, Christopher E, Sebolt-Leopold, Judith S

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The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer von Klein, Patrick J., Schmidt, C. Max, Wiesenauer, Chad A., Choi, Jennifer N., Gage, Earl A., Yip-Schneider, Michele T., Wiebke, Eric A., Wang, Yufang, Omer, Charles, Sebolt-Leopold, Judith S.

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